1997
DOI: 10.1046/j.1365-2141.1997.d01-2049.x
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Glucose metabolism in bone marrow cells and granulocytes of adult mice after X‐ray (5 Gy) irradiation: relationship to cell functionality

Abstract: Summary.Our experiments focused on the metabolic implications of the residual haemopoietic damage in adult mice given 5 Gy X-rays. Bone marrow cells from irradiated mice exhibited an increase in protein synthesis and a decrease in ATP levels, which could be related to the enhancement of the proliferative activity of haemopoietic precursor cells. However, the kinetic parameters (V max and K m ) of glucose uptake, the glycolytic flux and the hexose monophospate (HMP) shunt activity were similar to those found in… Show more

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Cited by 4 publications
(3 citation statements)
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“…Lack of SGLT1 may thus compromise glucose uptake, function and survival of granulocytes entering infected tissue with low extracellular glucose concentration. In addition, metabolism can regulate immune functions [37, 38]. Therefore lack of SGLT1 might induce an oxidative metabolism in granulocytes which could limit their function and survival [39].…”
Section: Discussionmentioning
confidence: 99%
“…Lack of SGLT1 may thus compromise glucose uptake, function and survival of granulocytes entering infected tissue with low extracellular glucose concentration. In addition, metabolism can regulate immune functions [37, 38]. Therefore lack of SGLT1 might induce an oxidative metabolism in granulocytes which could limit their function and survival [39].…”
Section: Discussionmentioning
confidence: 99%
“…These data indicate that the canine neutrophil energy metabolism was not altered under our culture conditions, enabling the cells to perform their physiological function. We also found ATP/ADP ratios which were higher than the one in murine neutrophils obtained from peripheral blood [34]and those produced in culture [35]. …”
Section: Discussionmentioning
confidence: 97%
“…Although the energetic yield from glucolysis only contributes with about 5% of total ATP-yield from the complete glucose catabolism, glycolysis can by itself account for a major part of energy production. For example, both neutrophils and myoblasts derive up 95% of their energy from glycolytic activity (Wiley & Beeson, 2002;Gaitain et al, 1997). Therefore, glucose consumption is a highly relevant indicator of cellular capacity to produce fuel for cellular work.…”
Section: Glucosementioning
confidence: 99%