Glucose Metabolism in Burns—What Happens?

Bădoiu, Silviu Constantin; Miricescu, Daniela; Stănescu-Spînu, Iulia-Ioana; Totan, Alexandra Ripszky; Badoiu, Silvia Elena; Costagliola, M; Greabu, Maria

doi:10.3390/ijms22105159

Cited by 13 publications

(11 citation statements)

References 215 publications

(320 reference statements)

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“…In the early stages of burn injury, an increase in glycolysis is beneficial for the body to withstand the injury and promote repair. However, if glycolysis is activated for an extended period, it not only hampers the energy supply but also leads to cellular damage and metabolic disorders due to lactate accumulation, resulting in unfavourable outcomes [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

1H-nuclear magnetic resonance analysis reveals dynamic changes in the metabolic profile of patients with severe burns

Su,

Zhang,

et al. 2024

Burns &Amp; Trauma

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Background Severe burn injury causes a hypermetabolic response, resulting in muscle protein catabolism and multiple organ damage syndrome. However, this response has not yet been continuously characterized by metabolomics in patients. This study aims to quantify temporal changes in the metabolic processes of patients with severe burns. Methods We employed 1H-nuclear magnetic resonance (NMR) spectroscopy to scrutinize metabolic alterations during the initial 35 days following burn injury in a cohort of 17 adult patients with severe burns, with 10 healthy individuals included as controls. Plasma specimens were collected from patients on postburn days 1, 3, 7, 14, 21, 28 and 35. After performing multivariate statistical analysis, repeated-measures analysis of variance and time-series analysis, we quantified changes in metabolite concentrations. Results Among the 36 metabolites quantified across 119 samples from burn patients, branched-chain amino acids, glutamate, glycine, glucose, pyruvate, lactate, trimethylamine N-oxide and others exhibited obvious temporal variations in concentration. Notably, these metabolites could be categorized into three clusters based on their temporal characteristics. The initial response to injury was characterized by changes in lactate and amino acids, while later changes were driven by an increase in fatty acid catabolism and microbial metabolism, leading to the accumulation of ketone bodies and microbial metabolites. Conclusions Metabolomics techniques utilizing NMR have the potential to monitor the intricate processes of metabolism in patients with severe burns. This study confirmed that the third day after burn injury serves as the boundary between the ebb phase and the flow phase. Furthermore, identification of three distinct temporal patterns of metabolites revealed the intrinsic temporal relationships between these metabolites, providing clinical data for optimizing therapeutic strategies.

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Section: Discussionmentioning

confidence: 99%

1H-nuclear magnetic resonance analysis reveals dynamic changes in the metabolic profile of patients with severe burns

Su,

Zhang,

et al. 2024

Burns &Amp; Trauma

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“…Our study excluded diabetic patients and focused on stress-induced hyperglycemia at admission. Burn injuries are accompanied by severe stress responses, which leads to the release of tumor necrosis factor-alpha, inhibiting tyrosine kinase and reducing tyrosine phosphorylation of insulin receptors 25 . In severe burns, IL-6 contributes to insulin resistance in the liver and skeletal muscles, acting upon insulin receptor substrates 26 .…”

Section: Discussionmentioning

confidence: 99%

Development and validation of a nomogram for pneumonia risk in burn patients with inhalation injury: a multicenter retrospective cohort study

Li,

et al. 2024

International Journal of Surgery

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Background: Burn patients with inhalation injury are at higher risk of developing pneumonia, and yet there is no reliable tool for the assessment of the risk for such patients at admission. This study aims to establish a predictive model for pneumonia risk for burn patients with inhalation injury based on clinical findings and laboratory tests. Method: This retrospective study enrolled 546 burn patients with inhalation injury. They were grouped into a training cohort and a validation cohort. The least absolute shrinkage and selection operator (LASSO) regression analysis and binary logistic regression analysis were utilized to identify risk factors for pneumonia. Based on the factors, a nomogram for predicting pneumonia in burn patients with inhalation injury was constructed. Areas under the receiver operating characteristic curves (AUC), calibration plots and decision curve analysis (DCA) were used to evaluate the efficiency of the nomogram in both the training and validation cohorts. Results: The training cohort included 432 patients, and the validation cohort included 114 patients, with a total of 225 (41.2%) patients experiencing pneumonia. Inhalation injury, tracheal intubation/tracheostomy, low serum albumin, and high blood glucose were independent risk factors for pneumonia in burn patients with inhalation injury and they were further used to build the nomogram. The AUC of the nomogram in the training and validation cohorts were 0.938 (95% CI, 0.917-0.960) and 0.966 (95% CI, 0.931-1), respectively. The calibration curve for probability of pneumonia showed optimal agreement between the prediction by nomogram and the actual observation, and the DCA indicated that the constructed nomogram conferred high clinical net benefit. Conclusion: This nomogram can accurately predict the risk of developing pneumonia for burn patients with inhalation injury, and help professionals to identify high-risk patients at an early stage as well as to make informed clinical decisions.

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“…In decreasing blood glucose levels, insulin acts as an anabolic hormone by increasing the diffusion of glucose through cell membranes in tissues. The anabolic effects of insulin hormone include inhibiting glycogenolysis, gluconeogenesis, and ketogenesis in the liver, increasing gluconeogenesis in bones and decreasing lipolysis in adipose tissue (Badoiu et al, 2021;Dewi et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

The Test Effect of Glucose Tolerance of Green Apple (Mallus sylvestris Mill.) Juice on Male White Mice

et al. 2022

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Diabetes Mellitus or diabetes is a disease characterized by an increase in blood sugar levels beyond normal limits due to disruption of carbohydrate metabolism due to a deficiency of the insulin hormone caused by impaired pancreatic function. Glucose tolerance is disturbed when a person's blood sugar level on the glucose tolerance test is above normal but not high enough. Green Apple (Mallus sylvestris Mill.) Glucose Tolerance Test. Against White Male Mice orally by measuring mice's blood sugar levels every 30 minutes for 3 hours at a dose of 1.12 g; 2.24 g; and 4.48 g. The study's results using the oral glucose tolerance test method showed that the glucose tolerance effect of green apple juice at a dose of 1.12 g averaged blood sugar levels from 160.33 mg/dl to 89.33 mg/dl, at a dose of 2.24 g. – average blood sugar level from 204.67 mg/dl to 122.33 mg/dl and a dose of 4.48 g average blood sugar level from 329.67 mg/dl to 175.00 mg/dl. At a dose of 4.48 g, it can provide a faster effect on lowering the glucose levels of the test animals from statistical testing utilizing the T-test obtained tcount ≤ ttable means that there is no significant difference between the test substance group and the normal group.

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Glucose Metabolism in Burns—What Happens?

Cited by 13 publications

References 215 publications

1H-nuclear magnetic resonance analysis reveals dynamic changes in the metabolic profile of patients with severe burns

1H-nuclear magnetic resonance analysis reveals dynamic changes in the metabolic profile of patients with severe burns

Development and validation of a nomogram for pneumonia risk in burn patients with inhalation injury: a multicenter retrospective cohort study

The Test Effect of Glucose Tolerance of Green Apple (Mallus sylvestris Mill.) Juice on Male White Mice

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