2020
DOI: 10.3389/fonc.2020.00317
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Glucose Metabolism on Tumor Plasticity, Diagnosis, and Treatment

Abstract: Malignant cells support tumor proliferation and progression by adopting to metabolic changes. Tumor cells altered metabolism by increasing glucose uptake and fermentation of glucose to lactate, even in the aerobic state and the presence of functioning mitochondria. Glucose metabolism in tumor plasticity has attracted great interests by clinicians and scientists in the past decades. This review discusses the previous and emerging researches on the tumor plasticity altered by changing glucose metabolism in diffe… Show more

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Cited by 125 publications
(92 citation statements)
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References 133 publications
(161 reference statements)
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“…1 F), indicating an increased reliance on ATP generation by glutamine-based mitochondrial OXPHOS. Consistent with these results, treatment with either 2DG [ 25 ] or 3PO [ 26 ], two glycolytic inhibitors, dramatically induced PARP cleavage under attached conditions ( Fig. 1 G).…”
Section: Resultssupporting
confidence: 81%
See 1 more Smart Citation
“…1 F), indicating an increased reliance on ATP generation by glutamine-based mitochondrial OXPHOS. Consistent with these results, treatment with either 2DG [ 25 ] or 3PO [ 26 ], two glycolytic inhibitors, dramatically induced PARP cleavage under attached conditions ( Fig. 1 G).…”
Section: Resultssupporting
confidence: 81%
“…Although metabolic reprogramming in cancer cells is now widely recognized to be important for cancer treatment, strategies that target the enhanced glycolytic activity in cancer have, so far, not been very successful clinically [ 25 ]. In contrast, several small-molecule glutaminase inhibitors, including BPTES and CB839, are currently being evaluated in pre-clinical and clinical trials for the treatment of various cancers [ 67 ].…”
Section: Discussionmentioning
confidence: 99%
“…The aberrant glucose metabolism in cancer cells associates with cell proliferation and resistance to radiation and chemotherapy. Tumor cells require higher rates of glucose uptake, and have higher catabolite uptake and use [65,66]. In breast cancer, CCR5 engagement induces Akt phosphorylation, stimulating glucose uptake, glycolysis, the pentose phosphate pathway, fatty acid synthesis, and glutamine metabolism [55].…”
Section: Deregulated Cellular Energetics (Metabolic Reprogramming)mentioning
confidence: 99%
“…Cysteine and glutathione are crucial in the maintenance of the metabolic course ( 10 ā€“ 13 ), since the cancer metabolic rewiring implies the generation of oxidative stress ( 14 ā€“ 16 ). Nevertheless, cysteine has been underestimated as a carbon source, due to the core position of glycolysis in the cellular biosynthesis and bioenergetics, being major emphasis given to glucose as a preferential fuel and to glutamine as its main substitute [as reviewed in ( 17 , 18 )].…”
Section: Introductionmentioning
confidence: 99%