Glucose oxidase and L-arginine functionalized black phosphorus nanosheets for multimodal targeted therapy of glioblastoma

Huang, Xin; Ren, Ke; Chang, Zhi-Yong; Ye, Youqing; Huang, Dechun; Zhao, Wei; Yang, Lixin; Dong, Yuqin; Cao, Zhi-Ting; Qiao, Haishi

doi:10.1016/j.cej.2021.132898

Cited by 31 publications

(16 citation statements)

References 51 publications

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“…Enzyme and enzyme delivery nano‐system: adapted with permission. [ 88 ] Copyright 2021, Elsevier B.V. Nanoparticles based on photocatalytic production of NO: adapted with permission. [ 90 ] Copyright 2022, Wiley‐VCH.…”

Section: Mechanism Of No Generation By Catalyst Reactionmentioning

confidence: 99%

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Recent Advances in Functional Nanomaterials for Catalytic Generation of Nitric Oxide: A Mini Review

Wang

Gan

et al. 2023

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As a gaseous second messenger, nitric oxide (NO) plays an important role in a series of signal pathways. Research on the NO regulation for various disease treatments has aroused wide concern. However, the lack of accurate, controllable, and persistent release of NO has significantly limited the application of NO therapy. Profiting from the booming development of advanced nanotechnology, a mass of nanomaterials with the properties of controllable release have been developed to seek new and effective NO nano‐delivery approaches. Nano‐delivery systems that generate NO through catalytic reactions exhibit unique superiority in terms of precise and persistent release of NO. Although certain achievements have been made in the catalytically active NO delivery nanomaterials, some basic but critical issues, such as the concept of design, are of low attention. Herein, an overview of the generation of NO through catalytic reactions and the design principles of related nanomaterials are summarized. Then, the nanomaterials that generate NO through catalytic reactions are classified. Finally, the bottlenecks and perspectives are also discussed in depth for the future development of catalytical NO generation nanomaterials.

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Section: Mechanism Of No Generation By Catalyst Reactionmentioning

confidence: 99%

“…Adapted with permission. [ 88 ] Copyright 2022, Elsevier B.V. e) Preparation process and therapeutic mechanism of the BAGM nanozyme. f) Generation of dissolved O 2 , H 2 O 2, and NO from BAGM under different conditions.…”

Section: Classification Of Catalytic No‐generation Nanomaterialsmentioning

confidence: 99%

Recent Advances in Functional Nanomaterials for Catalytic Generation of Nitric Oxide: A Mini Review

Wang

Gan

et al. 2023

Small

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“…The synthesis of MFG was performed by an amide reaction. N -Hydroxysuccinimide (NHS; 45 mg) and 75 mg of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) were mixed with 25 mL of GOD solution under stirring for the carboxylic group activation of GOD, , and then, 20 mg of MF was mixed with the above solution. After continuous stirring for 1 day, the product was washed several times with water to obtain MFG.…”

Section: Experimental Sectionmentioning

confidence: 99%

H₂O₂ Self-Supplementing and GSH-Depleting Nanoreactors Based on MoO_3–x@Fe₃O₄-GOD-PVP for Photothermally Reinforced Nanocatalytic Cancer Therapy at the Second Near-Infrared Biowindow

Huang

Zhu

et al. 2022

ACS Sustainable Chem. Eng.

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Nanocatalytic therapy is an emerging strategy for combating various malignant tumors, which is limited by acid/H 2 O 2 deficiency and overexpressed glutathione (GSH). Herein, the versatile MoO 3−x @Fe 3 O 4 -GOD-PVP (MFGP) nanoreactors were developed to overcome the limitations of nanocatalytic therapy. First, MoO 3−x nanoflakes were loaded with Fe 3 O 4 nanozymes via electrostatic self-assembly and then decorated with glucose oxidase (GOD) and polyvinylpyrrolidone (PVP). At the tumor microenvironment (TME), nanocatalytic therapy can be performed by the nanoreactors triggering a sequence of catalytic reactions. The hydroxyl radicals (•OH) generated by Fe 3 O 4 nanozymes triggering the Fenton reaction can kill cancer cells. GOD could not only consume the glucose of the TME to starve the tumor but also in situ generate gluconic acid/H 2 O 2 resulting in sustainable •OH production. In addition, overexpressed GSH, an antioxidant of cancer cells, would be effectively consumed via Mo triggering redox reactions. Importantly, due to the strong second near-infrared (NIR-II) absorption of MoO 3−x nanoflakes, MFGP possessed an excellent photothermal property (photothermal conversion efficiency of 49.9%). The generated hyperthermia by MFGP can simultaneously enhance the Fenton reaction efficiency, GOD catalytic reaction, and GSH depletion. Extensive biomedical evaluations demonstrated the desirable tumor suppression effect based on hyperthermiaaugmented nanocatalytic therapy. Overall, this work paves the way to the exploration of tumor nanocatalytic therapy.

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“…It is worth noting that an effective, transition metal ions‐catalyzed Fenton reaction typically requires high H 2 O 2 concentration and acidic condition (pH 3–4), [ 22 ] and an effective oxidization reaction of Arg into NO also requires a high level of H 2 O 2 and a low pH environment. [ 21d,23 ] Whereas, the concentration of intratumoral H 2 O 2 is considerably low (≈100 µM) and the pH value in the tumor microenvironment is around 6.5. [ 24 ] Thus, the elaborately designed Arg/Fc@GOx/HA nanozymes could concurrently generate ROS and NO in the same region to generate ONOO − .…”

Section: Introductionmentioning

confidence: 99%

Inflammatory Cell‐Inspired Cascade Nanozyme Induces Intracellular Radical Storm for Enhanced Anticancer Therapy

Liu

Wang

et al. 2023

Small Methods

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Manipulating intracellular levels of reactive oxygen and nitrogen species (RONS) is of great potential for cancer treatment. Inspired by the natural mechanism of a radical storm in inflammatory cells via activated and regulatable biocatalysis, the authors herein report a self‐powered nanozyme that can enable RONS production in tumor cells via cascade reactions. The nanozymes are constructed via glucose oxidase (GOx)‐templated inverse microemulsion polymerization from acrylamide, arginine‐acrylamide, ferrocene‐acrylate, and N,N′‐bis(acryloyl)cystamine, followed by surface coating with hyaluronic acid. After targeted delivery into cancer cells, the nanozymes are dissociated by intracellular glutathione to release GOx, which decomposed glucose to generate gluconic acid and H2O2. Under such acidified conditions, H2O2 efficiently oxidized pendant arginine residues to produce nitric oxide , transformed into a highly toxic hydroxyl radical and superoxide anion via ferrocene‐mediated Fenton reaction and Haber–Weiss cycle, and simultaneously generated peroxynitrite anion via reaction between NO and ·O2−, thus provoking the RONS radical storm to effectively eradicate A549 tumor cells both in vitro and in vivo. This nature‐inspired enzyme‐chemical dynamic therapy may provide a promising modality for anti‐cancer treatment.

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Glucose oxidase and L-arginine functionalized black phosphorus nanosheets for multimodal targeted therapy of glioblastoma

Cited by 31 publications

References 51 publications

Recent Advances in Functional Nanomaterials for Catalytic Generation of Nitric Oxide: A Mini Review

Recent Advances in Functional Nanomaterials for Catalytic Generation of Nitric Oxide: A Mini Review

H₂O₂ Self-Supplementing and GSH-Depleting Nanoreactors Based on MoO_3–x@Fe₃O₄-GOD-PVP for Photothermally Reinforced Nanocatalytic Cancer Therapy at the Second Near-Infrared Biowindow

Inflammatory Cell‐Inspired Cascade Nanozyme Induces Intracellular Radical Storm for Enhanced Anticancer Therapy

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Glucose oxidase and L-arginine functionalized black phosphorus nanosheets for multimodal targeted therapy of glioblastoma

Cited by 31 publications

References 51 publications

Recent Advances in Functional Nanomaterials for Catalytic Generation of Nitric Oxide: A Mini Review

Recent Advances in Functional Nanomaterials for Catalytic Generation of Nitric Oxide: A Mini Review

H2O2 Self-Supplementing and GSH-Depleting Nanoreactors Based on MoO3–x@Fe3O4-GOD-PVP for Photothermally Reinforced Nanocatalytic Cancer Therapy at the Second Near-Infrared Biowindow

Inflammatory Cell‐Inspired Cascade Nanozyme Induces Intracellular Radical Storm for Enhanced Anticancer Therapy

Contact Info

Product

Resources

About

H₂O₂ Self-Supplementing and GSH-Depleting Nanoreactors Based on MoO_3–x@Fe₃O₄-GOD-PVP for Photothermally Reinforced Nanocatalytic Cancer Therapy at the Second Near-Infrared Biowindow