Glucose‐Responsive Insulin and Delivery Systems: Innovation and Translation

Wang, Jinqiang; Wang, Zejun; Yu, Jicheng; Kahkoska, Anna R.; Buse, John B.; Gu, Zhen

doi:10.1002/adma.201902004

Cited by 176 publications

(155 citation statements)

References 200 publications

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“…The hydrogel/microneedle array may act as a patch on the skin for the autonomous sensing of glucose in subcutaneous uids followed by the autonomous release of insulin and its sequestered delivery to the body. 63…”

Section: Resultsmentioning

confidence: 99%

Biocatalytic reversible control of the stiffness of DNA-modified responsive hydrogels: applications in shape-memory, self-healing and autonomous controlled release of insulin

et al. 2020

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Section: Resultsmentioning

confidence: 99%

Biocatalytic reversible control of the stiffness of DNA-modified responsive hydrogels: applications in shape-memory, self-healing and autonomous controlled release of insulin

et al. 2020

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“…Apart from sustained release, “smart” materials with the ability to sense signals within the physiological environment and react correspondingly are gaining attention for applications in drug delivery, tissue engineering, and biomedical devices. [ 9–15 ] As reported in previous studies, tissue injuries lead to site‐dependent environmental changes and abnormal cellular activity. Multiple factors, including enzymes, [ 16–36 ] reduction and oxidation (redox) reactions, [ 37–44 ] hypoxia, [ 32,45–49 ] pH, [ 47,50–54 ] temperature, [ 55–57 ] and the other characteristics, [ 42,58–60 ] become dysregulated at the onset of injury or during the progression of the healing ( Figure A).…”

Section: Introductionmentioning

confidence: 87%

Stimuli‐Responsive Delivery of Growth Factors for Tissue Engineering

Jiang

Zhou

et al. 2020

Adv Healthcare Materials

105

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Growth factors (GFs) play a crucial role in directing stem cell behavior and transmitting information between different cell populations for tissue regeneration. However, their utility as therapeutics is limited by their short half‐life within the physiological microenvironment and significant side effects caused by off‐target effects or improper dosage. “Smart” materials that can not only sustain therapeutic delivery over a treatment period but also facilitate on‐demand release upon activation are attracting significant interest in the field of GF delivery for tissue engineering. Three properties are essential in engineering these “smart” materials: 1) the cargo vehicle protects the encapsulated therapeutic; 2) release is targeted to the site of injury; 3) cargo release can be modulated by disease‐specific stimuli. The aim of this review is to summarize the current research on stimuli‐responsive materials as intelligent vehicles for controlled GF delivery; Five main subfields of tissue engineering are discussed: skin, bone and cartilage, muscle, blood vessel, and nerve. Challenges in achieving such “smart” materials and perspectives on future applications of stimuli‐responsive GF delivery for tissue regeneration are also discussed.

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“…One promising approach for ISF extraction is the use of microneedle (MN) array patches 13–15. Historically, MNs were developed for the delivery of drugs,16–18 vaccines,19,20 biomolecules,21,22 or stem cells 23. The extensive focus on developing MN‐based delivery approaches rather than extraction methods may be the result of the lack of excellent ISF‐absorbing materials.…”

Section: Figurementioning

confidence: 99%

Gelatin Methacryloyl Microneedle Patches for Minimally Invasive Extraction of Skin Interstitial Fluid

Zhu

Zhou

Kim

et al. 2020

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130

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The extraction of interstitial fluid (ISF) from skin using microneedles (MNs) has attracted growing interest in recent years due to its potential for minimally invasive diagnostics and biosensors. ISF collection by absorption into a hydrogel MN patch is a promising way that requires the materials to have outstanding swelling ability. Here, a gelatin methacryloyl (GelMA) patch is developed with an 11 × 11 array of MNs for minimally invasive sampling of ISF. The properties of the patch can be tuned by altering the concentration of the GelMA prepolymer and the crosslinking time; patches are created with swelling ratios between 293% and 423% and compressive moduli between 3.34 MPa and 7.23 MPa. The optimized GelMA MN patch demonstrates efficient extraction of ISF. Furthermore, it efficiently and quantitatively detects glucose and vancomycin in ISF in an in vivo study. This minimally invasive approach of extracting ISF with a GelMA MN patch has the potential to complement blood sampling for the monitoring of target molecules from patients.

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Glucose‐Responsive Insulin and Delivery Systems: Innovation and Translation

Cited by 176 publications

References 200 publications

Biocatalytic reversible control of the stiffness of DNA-modified responsive hydrogels: applications in shape-memory, self-healing and autonomous controlled release of insulin

Biocatalytic reversible control of the stiffness of DNA-modified responsive hydrogels: applications in shape-memory, self-healing and autonomous controlled release of insulin

Stimuli‐Responsive Delivery of Growth Factors for Tissue Engineering

Gelatin Methacryloyl Microneedle Patches for Minimally Invasive Extraction of Skin Interstitial Fluid

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