Glucose-responsive nanostructured hydrogels with enhanced elastic and swelling properties

Organic acids under pressure: elastic properties, negative mechanical phenomena and pressure induced phase transitions in the lactic, maleic, succinic and citric acids

“…The mechanical effects of pressure on compounds of biological interest have been utilized in a plethora of applications in biomedicine and biotechnology. 79,100,[143][144][145][146] Very successful applications of the use of high pressure have been achieved in the pharmaceutical 103,104,[154][155][156][157] and food industries 89, 95,106,[158][159][160][161][162][163][164][165][166][167] for the manufacturing, decontamination, sterilization, disinfection, sanitization, conservation and low volume storage of chemical products and foods.…”

Thermoresponsive polymers with LCST transition: synthesis, characterization, and their impact on biomedical frontiers

“…This phenomenon in turn limits the accessibility of the phenylboronic acid component for glucose complexation as its conformation changes from coil to globule shape. 311 Fluorescent dyes can also be incorporated into the polymers for development of biosensors. Mao et al utilized OEGylated cyclodextrin-based thermoresponsive polymers as switchable inclusion complexes for fluorescent dyes.…”

Hydrogel‐based composites: Unlimited platforms for biosensors and diagnostics

“…[ 247–249 ] The introduction of biocompatible hydrogels improves the immobilization and stabilization of GOx and the permeation of water‐soluble molecules, which facilitate the effective oxidation of glucose. [ 58,75 ] For example, by combining GOx with PtNPs/PANI composite hydrogel, Zhai and coworkers prepared a highly sensitive glucose sensor, exhibiting high sensitivity up to 96.1 μA·mM –1 ·cm –2 , a linear range of 0.01–8 mM and a low detection limit of 0.7 μM (Figure 8A, B). The excellent performance was attributed to the collective contribution from the porous and conductive PANI hydrogel for enzyme immobilization, ion diffusion and charge transfer, and the catalytic PtNPs that boost the decomposition of H 2 O 2 (the product of glucose oxidation) to provide additional electrochemical signals.…”

“…Up to now, various hydrogel composite‐based biosensors, working via various electrical [ 52–54 ] and optical [ 55–57 ] transducing pathways, have been successfully used in the sensitive and selective detection of various biomarkers or physiological signals, such as diabetes‐related glucose and lactate, [ 58,59 ] cancer‐related microRNAs and protein, [ 60,61 ] cardiovascular disease‐related triglyceride (TG) and heartbeat (pulse), [ 62–64 ] and arthritis‐related collagenase and uric acid, [ 65,66 ] demonstrating their great potential in future portable and wearable health monitoring and diagnostic toolsets.…”