Glucose Sensing in the Hepatic Portal Vein and Its Role in Food Intake and Reward

Bacharach, Sam Z; Tordoff, Michael G.; Alhadeff, Amber L.

doi:10.1016/j.jcmgh.2023.03.012

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2024

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Cited by 5 publications

References 119 publications

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Intestinal gluconeogenesis: A translator of nutritional information needed for glycemic and emotional balance

Gautier-Stein,

Vily-Petit,

Rajas

et al. 2024

Biochimie

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Intestinal gluconeogenesis: A translator of nutritional information needed for glycemic and emotional balance

Gautier-Stein,

Vily-Petit,

Rajas

et al. 2024

Biochimie

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Sucrose overconsumption impairs AgRP neuron dynamics and promotes palatable food intake

Lorch,

Hayes,

Xia

et al. 2024

Cell Reports

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Liver-innervating vagal sensory neurons are indispensable for the development of hepatic steatosis and anxiety-like behavior in diet-induced obese mice

Hwang,

Lee,

Okada

et al. 2024

Preprint

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The visceral organ-brain axis, mediated by vagal sensory neurons in the vagal nerve ganglion, is essential for maintaining various physiological functions. These vagal sensory neurons relay interoceptive signals from visceral organs to the medulla. In this study, we investigate the influence of the loss of the liver-brain axis on energy balance, glucose homeostasis, and hepatic steatosis in mice under obesogenic conditions. A subset of vagal sensory neurons innervating the liver is located in both the left and right ganglia, projecting centrally to the nucleus of the tractus solitarius, area postrema, and dorsal motor nucleus of the vagus, and peripherally to the periportal areas in the liver. Ablation of the liver-brain axis via caspase-induced selective destruction of advillin-positive neurons prevents diet-induced obesity in male and female mice, and these outcomes are associated with increased energy expenditure. Although males and females exhibit improved glucose homeostasis following disruption of the liver-brain axis, only male mice display increased insulin sensitivity. Furthermore, loss of the liver-brain axis limits the progression of hepatic steatosis in male and female mice fed a steatogenic diet. Therefore, modulation of the liver-brain axis may present a therapeutic strategy for restoring lipid metabolism and glucose homeostasis in obesity and diabetes.

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Glucose Sensing in the Hepatic Portal Vein and Its Role in Food Intake and Reward

Cited by 5 publications

References 119 publications

Intestinal gluconeogenesis: A translator of nutritional information needed for glycemic and emotional balance

Intestinal gluconeogenesis: A translator of nutritional information needed for glycemic and emotional balance

Sucrose overconsumption impairs AgRP neuron dynamics and promotes palatable food intake

Liver-innervating vagal sensory neurons are indispensable for the development of hepatic steatosis and anxiety-like behavior in diet-induced obese mice

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