Glucose-sensitive delivery of metronidazole by using a photo-crosslinked chitosan hydrogel film to inhibit Porphyromonas gingivalis proliferation

Liu, Junyu; Xiao, Yu; Wang, Xiangyu; Huang, Lixun; Chen, Yu; Bao, Chongyun

doi:10.1016/j.ijbiomac.2018.09.202

Cited by 52 publications

(20 citation statements)

References 47 publications

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“…In many studies, chitosan in its various forms is considered bactericidal [43,44], but these properties have recently been limited to biostatic ones [45][46][47][48]. The research carried out in the present work will also be useful in explaining this phenomenon.…”

Section: Introductionmentioning

confidence: 85%

Silver Nanoparticles on Chitosan/Silica Nanofibers: Characterization and Antibacterial Activity

Zienkiewicz-Strzałka

Deryło–Marczewska

Skorik

et al. 2019

IJMS

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A simple, low-cost, and reproducible method for creating materials with even silver nanoparticles (AgNP) dispersion was established. Chitosan nanofibers with silica phase (CS/silica) were synthesized by an electrospinning technique to obtain highly porous 3D nanofiber scaffolds. Silver nanoparticles in the form of a well-dispersed metallic phase were synthesized in an external preparation step and embedded in the CS/silica nanofibers by deposition for obtaining chitosan nanofibers with silica phase decorated by silver nanoparticles (Ag/CS/silica). The antibacterial activity of investigated materials was tested using Gram-positive and Gram-negative bacteria. The results were compared with the properties of the nanocomposite without silver nanoparticles and a colloidal solution of AgNP. The minimum inhibitory concentration (MIC) of obtained AgNP against Staphylococcus aureus (S. aureus) ATCC25923 and Escherichia coli (E. coli) ATCC25922 was determined. The physicochemical characterization of Ag/CS/silica nanofibers using various analytical techniques, as well as the applicability of these techniques in the characterization of this type of nanocomposite, is presented. The resulting Ag/CS/silica nanocomposites (Ag/CS/silica nanofibers) were characterized by small angle X-ray scattering (SAXS), X-ray diffraction (XRD), and atomic force microscopy (AFM). The morphology of the AgNP in solution, both initial and extracted from composite, the properties of composites, the size, and crystallinity of the nanoparticles, and the characteristics of the chitosan fibers were determined by electron microscopy (SEM and TEM).

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Section: Introductionmentioning

confidence: 85%

Silver Nanoparticles on Chitosan/Silica Nanofibers: Characterization and Antibacterial Activity

Zienkiewicz-Strzałka

Deryło–Marczewska

Skorik

et al. 2019

IJMS

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“…Additionally, self-healing hydrogels are good candidates for 3D printing technologies unlike classical covalent hydrogels which can be irreversibly damaged during the extrusion process [ 204 ]. Finally, other routes are being investigated to develop stimuli responsive hydrogel-based scaffolds, Liu et al [ 205 ] generated a chitosan-based hydrogel with glucose oxidase immobilized on the surface as a promising solution for the regulation of glucose level in blood. pH-sensitive hydrogels are also interesting for drug delivery applications [ 206 ].…”

Section: Review Of the Influence Of The Scaffold Architecture On Cmentioning

confidence: 99%

The Overview of Porous, Bioactive Scaffolds as Instructive Biomaterials for Tissue Regeneration and Their Clinical Translation

2020

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Porous scaffolds have been employed for decades in the biomedical field where researchers have been seeking to produce an environment which could approach one of the extracellular matrixes supporting cells in natural tissues. Such three-dimensional systems offer many degrees of freedom to modulate cell activity, ranging from the chemistry of the structure and the architectural properties such as the porosity, the pore, and interconnection size. All these features can be exploited synergistically to tailor the cell–material interactions, and further, the tissue growth within the voids of the scaffold. Herein, an overview of the materials employed to generate porous scaffolds as well as the various techniques that are used to process them is supplied. Furthermore, scaffold parameters which modulate cell behavior are identified under distinct aspects: the architecture of inert scaffolds (i.e., pore and interconnection size, porosity, mechanical properties, etc.) alone on cell functions followed by comparison with bioactive scaffolds to grasp the most relevant features driving tissue regeneration. Finally, in vivo outcomes are highlighted comparing the accordance between in vitro and in vivo results in order to tackle the future translational challenges in tissue repair and regeneration.

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“…The introduction of silane coupling agent is one of the most widely studied methods in crosslinking modification. The flexible siloxane segments, possessing one or more functional groups such as hydroxyl and amino, can be used as end‐capping agent or chain extender 8,9 . For example, Liang introduced trimethoxysilane (3‐[2‐aminoethyl] aminopropyl) to synthesize a group of water‐based polyurethanes containing alkoxy silane groups in side chains that had low‐water absorption and high‐thermal properties with an addition of 2.0% by weight 10 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of eugenol‐based silicone modified waterborne polyurethane with excellent properties

Zhang

Cai

Zhang

et al. 2021

J of Applied Polymer Sci

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A eugenol‐based silicone‐containing monomer 4,4′‐(1,1,3,3‐tetramethyldisiloxane‐1,3‐dipropyl)bis‐2‐methoxyphenol(EUSi) was synthesized from eugenol and 1,1,3,3‐tetramethyldisiloxane via the hydrosilylation reaction. And waterborne polyurethane (WPU) with excellent properties was obtained by using EUSi as a type of diol chain extender. The unique combination of rigidity and flexibility in the chemical structure of EUSi greatly facilitated the mechanical properties, thermal properties, and water resistance of WPU. With only a 3% dosage of EUSi, the maximum tensile strength was increased from 6.2 to 22.4 MPa, while the water absorption was decreased from 31.3% to a surprisingly 7.6%. Our work provides a new convenient strategy for the preparation of organosilicon‐modified WPU with improved performance.

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Glucose-sensitive delivery of metronidazole by using a photo-crosslinked chitosan hydrogel film to inhibit Porphyromonas gingivalis proliferation

Cited by 52 publications

References 47 publications

Silver Nanoparticles on Chitosan/Silica Nanofibers: Characterization and Antibacterial Activity

Silver Nanoparticles on Chitosan/Silica Nanofibers: Characterization and Antibacterial Activity

The Overview of Porous, Bioactive Scaffolds as Instructive Biomaterials for Tissue Regeneration and Their Clinical Translation

Synthesis and characterization of eugenol‐based silicone modified waterborne polyurethane with excellent properties

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