Glucose-sensitive polyelectrolyte microcapsules based on (alginate/chitosan) pair

Belbekhouche, Sabrina; Charaabi, Saddam; Picton, Luc; Cerf, Didier Le; Carbonnier, Benjamin

doi:10.1016/j.carbpol.2017.12.054

Cited by 41 publications

(23 citation statements)

References 49 publications

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“…However, the linear range of glucose determination for the biosensor based on PMC is broader (0.10 -5.50 and 0.05 -0.60 mM, respectively). In one study, 35 its authors used quartz sensors to also study GOx-containing polyelectrolyte capsules. The application of natural polyelectrolytes, alginate and chitosan, led to the swelling of films and, correspondingly, to a change of the reaction to glucose, as it can be incorporated into produced polyelectrolyte complexes.…”

Section: Discussionmentioning

confidence: 99%

Comparative Study of Electrochemical Sensors Based on Enzyme Immobilized into Polyelectrolyte Microcapsules and into Chitosan Gel

et al. 2019

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The characteristics of an electrochemical biosensor based on a Prussian-blue screen-printed electrode containing glucose oxidase incorporated into polyelectrolyte microcapsules (PMC) are considered. PMC with the embedded enzyme were formed using sodium polystyrene sulfonate and poly(allylamine hydrochloride). The characteristics were compared with those of the enzyme immobilized in chitosan gel. We assessed the dependences of biosensor signals on the composition of the buffer solution, on the glucose concentration; the operational and long-term stabilities. The enzyme immobilized in PMC proved to be more sensitive to buffer molarity at a maximum within 35-40 mM. The apparent Michaelis constants were 1.5 and 4.1 mM at the immobilization in, respectively, chitosan and PMC. The developed biosensors were used to assay commercial juices. The biosensors' data on the glucose contents were shown to have a high correlation with the standard spectrophotometric assay (0.92-0.95%), which implies a possible application of the fabricated biosensors in foodstuff analysis.

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Section: Discussionmentioning

confidence: 99%

Comparative Study of Electrochemical Sensors Based on Enzyme Immobilized into Polyelectrolyte Microcapsules and into Chitosan Gel

et al. 2019

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“…Biomaterials can be engineered to respond specifically to the microenvironment of the site of injury or disease, 148 as is often done with the acidic environment of cancer cells. 114,149 pH sensitive vehicles are typically made through the integration of polyelectrolytes, such as phenylboronic acid (PBA), [150][151][152] due to their ability to change their overall charge at different pH, resulting in triggered release. 114,153,154 Cong et al crosslinked chitosan with glycerol 2-phospate disodium to created pH sensitive micelles, which were then dispersed in an alginate hydrogel.…”

Section: Environmentally-responsive Materialsmentioning

confidence: 99%

Biomaterials for protein delivery for complex tissue healing responses

2021

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“…The aforementioned vaterite CaCO 3 crystals are widely used as sacrificial cores for the fabrication of PEMCs [ 37 , 38 , 39 ] as well as larger tailor-made polymer based structures like porous polymer scaffolds [ 40 , 41 , 42 , 43 ]. The vaterite polymorph belongs to a family of naturally derived minerals [ 44 ], but can be readily produced from low-cost precursor salts (e.g., sodium carbonate and calcium chloride) at either the micro- or nanoscale [ 45 , 46 ].…”

Section: The Development Of Polyelectrolyte Multilayer Capsules (Pmentioning

confidence: 99%

Encapsulation of Low-Molecular-Weight Drugs into Polymer Multilayer Capsules Templated on Vaterite CaCO3 Crystals

2020

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Polyelectrolyte multilayer capsules (PEMCs) templated onto biocompatible and easily degradable vaterite CaCO3 crystals via the layer-by-layer (LbL) polymer deposition process have served as multifunctional and tailor-made vehicles for advanced drug delivery. Since the last two decades, the PEMCs were utilized for effective encapsulation and controlled release of bioactive macromolecules (proteins, nucleic acids, etc.). However, their capacity to host low-molecular-weight (LMW) drugs (<1–2 kDa) has been demonstrated rather recently due to a limited retention ability of multilayers to small molecules. The safe and controlled delivery of LMW drugs plays a vital role for the treatment of cancers and other diseases, and, due to their tunable and inherent properties, PEMCs have shown to be good candidates for smart drug delivery. Herein, we summarize recent progress on the encapsulation of LMW drugs into PEMCs templated onto vaterite CaCO3 crystals. The drug loading and release mechanisms, advantages and limitations of the PEMCs as LMW drug carriers, as well as bio-applications of drug-laden capsules are discussed based upon the recent literature findings.

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Glucose-sensitive polyelectrolyte microcapsules based on (alginate/chitosan) pair

Cited by 41 publications

References 49 publications

Comparative Study of Electrochemical Sensors Based on Enzyme Immobilized into Polyelectrolyte Microcapsules and into Chitosan Gel

Comparative Study of Electrochemical Sensors Based on Enzyme Immobilized into Polyelectrolyte Microcapsules and into Chitosan Gel

Biomaterials for protein delivery for complex tissue healing responses

Encapsulation of Low-Molecular-Weight Drugs into Polymer Multilayer Capsules Templated on Vaterite CaCO3 Crystals

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