Glucose starvation induces NADPH collapse and disulfide stress in SLC7A11high cancer cells

Liu, Xiaoguang; Gan, Boyi

doi:10.18632/oncotarget.27993

Cited by 7 publications

(8 citation statements)

References 14 publications

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“…Additionally, in SLC7A11-overexpressing cells, proteins showing the greatest increase in disulfide bonds during glucose deprivation were primarily associated with biological processes or pathways related to the actin cytoskeleton and cell adhesion. This results in abnormal disulfide bonding of actin skeleton proteins, leading to subsequent F-actin contraction [140].…”

Section: Disulfidptosismentioning

confidence: 99%

Challenges of Regulated Cell Death: Implications for Therapy Resistance in Cancer

D’Amico,

De Amicis

2024

Cells

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Regulated cell death, a regulatory form of cell demise, has been extensively studied in multicellular organisms. It plays a pivotal role in maintaining organismal homeostasis under normal and pathological conditions. Although alterations in various regulated cell death modes are hallmark features of tumorigenesis, they can have divergent effects on cancer cells. Consequently, there is a growing interest in targeting these mechanisms using small-molecule compounds for therapeutic purposes, with substantial progress observed across various human cancers. This review focuses on summarizing key signaling pathways associated with apoptotic and autophagy-dependent cell death. Additionally, it explores crucial pathways related to other regulated cell death modes in the context of cancer. The discussion delves into the current understanding of these processes and their implications in cancer treatment, aiming to illuminate novel strategies to combat therapy resistance and enhance overall cancer therapy.

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Section: Disulfidptosismentioning

confidence: 99%

Challenges of Regulated Cell Death: Implications for Therapy Resistance in Cancer

D’Amico,

De Amicis

2024

Cells

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“…Recent findings show a close link between disulfide metabolism and cancer. Disruption of disulfide metabolism in cancer cells affects survival, proliferation, drug resistance, metastasis, and immune evasion [ [8] , [9] , [10] ]. Disulfide catastrophe, a form of programmed cell death, may be related to tumor immune response.…”

Section: Introductionmentioning

confidence: 99%

Disulfidptosis-related lncRNA signature reveals immune microenvironment and novel molecular subtyping of stomach adenocarcinoma

Li,

Xia,

Song

et al. 2024

Heliyon

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“…Consequently, pronounced cytoskeletal contraction and detachment from the cellular membrane ensue, engendering disruptive distortions in cytoskeletal architecture, culminating inexorably in cellular demise. Ongoing investigations into disulfidptosis predominantly orbit around cancerous cell cohorts exhibiting augmented SLC7A11 expression amidst glucose-deprived microenvironments [ 4 , 5 ]. Studies have discerned compelling associations linking disulfidptosis with a panoply of malignancies, spanning from bladder cancer [ 6 ] to hepatocellular carcinoma [ 7 ] and lung adenocarcinoma [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of disulfidptosis-associated genes and characterization of immune cell infiltration in thyroid carcinoma

Song,

Zhou,

Zhang

et al. 2024

Aging

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Objective: The primary objective of this study is to conduct a comprehensive screening and analysis of differentially expressed genes related to disulfidoptosis (DEDRGs) in thyroid carcinoma (THCA). This entails delving into the intricate characterization of immune cell infiltration within the THCA context and subsequently formulating and validating a novel prognostic model. Method: To achieve our objectives, we first delineated two distinct subtypes of disulfidoptosis-related genes (DRGs) via consensus clustering methodology. Subsequently, employing the limma R package, we identified the DEDRGs critical for our investigation. These DEDRGs underwent meticulous validation across various databases, alongside an in-depth analysis of gene regulation. Employing functional enrichment techniques, we explored the potential molecular mechanisms underlying disulfidoptosis in THCA. Furthermore, we scrutinized the immune landscape within the two identified subtypes utilizing CIBERSORT and ESTIMATE algorithms. The construction of the prognostic model for THCA entailed intricate methodologies including univariate, multivariate Cox regression, and LASSO regression algorithms. The validity and efficacy of our prognostic model were corroborated through Kaplan-Meier survival curves and ROC curves. Additionally, a nomogram was meticulously formulated to facilitate the prediction of patient prognosis. To fortify our findings, we conducted a comprehensive Bayesian co-localization analysis coupled with rigorous in vitro experimentation, aimed at unequivocally establishing the validity of the identified DEDRGs. Result: Our analyses unveiled Cluster C1, characterized by elevated expression levels of DEDRGs, as harboring a favorable prognosis accompanied by abundant immune cell infiltration. Correlation analyses underscored predominantly positive associations among the DEDRGs, further affirming their significance in THCA. Differential expression patterns of DEDRGs between tumor samples and normal tissues were evident across the GEPIA and HPA databases. Insights from the TIMER database underscored a robust correlation between DEDRGs and immune cell infiltration. KEGG analysis elucidated the enrichment of DEDRGs primarily in pivotal pathways including MAPK, PPAR signaling pathway, and Proteoglycans in cancer. Furthermore, analyses using CIBERSORT and ESTIMATE algorithms shed light on the crucial role played by DEDRGs in shaping the immune microenvironment. The prognostic model, anchored by five genes intricately associated with THCA prognosis, exhibited commendable predictive accuracy and was intricately linked to the tumor immune microenvironment. Notably, patients categorized with low-risk scores stood to potentially benefit more from immunotherapy. The validation of DEDRGs unequivocally underscores the protective role of INF2 in THCA. Conclusion: In summary, our study delineates two discernible subtypes intricately associated with DRGs, revealing profound disparities in immun...

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Glucose starvation induces NADPH collapse and disulfide stress in SLC7A11high cancer cells

Cited by 7 publications

References 14 publications

Challenges of Regulated Cell Death: Implications for Therapy Resistance in Cancer

Challenges of Regulated Cell Death: Implications for Therapy Resistance in Cancer

Disulfidptosis-related lncRNA signature reveals immune microenvironment and novel molecular subtyping of stomach adenocarcinoma

Identification of disulfidptosis-associated genes and characterization of immune cell infiltration in thyroid carcinoma

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