Glucose tolerance and vitamin D: Effects of treating vitamin D deficiency

Tai, Kamilia; Need, A. G.; Horowitz, Michael; Chapman, Ian

doi:10.1016/j.nut.2008.04.009

Cited by 99 publications

(68 citation statements)

References 33 publications

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“…The treatment had no apparent effect on fasting glucose in non-glucose-impaired subjects, nor was any effect observed on blood glucose or insulin metabolism in non-diabetic subjects when their VTD levels were corrected [41].…”

Section: Vitamin D and Type 2 Diabetes Mellitus: Interventional Studiesmentioning

confidence: 83%

Vitamin D and type 2 diabetes mellitus: Where do we stand?

Cavalier

Souberbielle

Radermecker

2011

Diabetes & Metabolism

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Section: Vitamin D and Type 2 Diabetes Mellitus: Interventional Studiesmentioning

confidence: 83%

Vitamin D and type 2 diabetes mellitus: Where do we stand?

Cavalier

Souberbielle

Radermecker

2011

Diabetes & Metabolism

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“…Wu et al (2009) suggested that calcium intake or systemic Vit D status, after adjusting for the intake of dairy products, is associated with decreased insulin secretion in men and women. There is no clinical impact of hypovitaminosis D on metabolic or glycemic control or on markers of systemic inflammation in Chinese T2D, and the correction of Vit D deficiency would not have great clinical utility on glucose tolerance or insulin sensitivity as a diabetes therapeutic agent in established diabetes (Luo et al, 2009;Tai et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Biochemical efficacy of vitamin D in ameliorating endocrine and metabolic disorders in diabetic rats

Sadek¹,

Shaheen

2013

Pharmaceutical Biology

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Context: Due to the biochemical role of vitamin D (Vit D) in the endocrine system, especially its potential anti-inflammatory and immune-modulating properties, there is an increased interest in its potential role in the prevention and control of diabetes mellitus. Objective: This study evaluated the potential therapeutic efficacy of Vit D in averting the detrimental effects of both types of diabetes mellitus. Materials and methods: A total of 50 male Wistar rats were allotted into five groups: a placebo group; a nongenetic model of type 1 diabetes in rats (T1D), injected with a single dose of streptozotocin (STZ; 65 mg/kg, ip); a nongenetic model of type 2 diabetes in rats (T2D), given a short-term high-fat diet followed by a single low dose of STZ (35 mg/kg, ip); fourth and fifth groups that were gastrogavaged with Vit D (10 IU/kg) three days after the induction of T1D and T2D, respectively, which was continued daily throughout the experiment. Results: Vit D (10 IU/kg/60 days) significantly (p50.05) decreased fasting plasma glucose, ketoacidosis (decreased non-esterified fatty acid and b-hydroxyl butyric acid), pro-inflammatory interleukin-6, HbA1c in T1D and T2D and insulin resistance index by 33% in T2D. Interestingly, Vit D significantly (p50.05) increased fasting plasma insulin by 144% in T1D, plasma Ca level, insulin sensitivity index, and b-cell function index in T1D and T2D. Discussion and conclusion: Vit D ameliorated the deleterious biochemical impact of diabetes mellitus, likely by increasing insulin secretion and sensitivity, ameliorating the b-cell function, and decreasing the number of pro-inflammatory cytokines and insulin resistance.

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“…The reason for these discrepant results could be the nature of the studied cohorts, or the way insulin sensitivity assessment was made. Finally, a recent interventional study (35) showed that in adults without diabetes, correction of vitamin D deficiency is not associated with any effect on blood glucose or insulin sensitivity (assessed by an oral glucose tolerance test), adding more controversies to the subject.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D in relation to metabolic risk factors, insulin sensitivity and adiponectin in a young Middle-Eastern population

Gannagé‐Yared¹,

Chedid²,

Khalife³

et al. 2009

European Journal of Endocrinology

161

134

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Objectives: Several studies suggest a link between circulating 25-hydroxyvitamin D (25(OH)D) and metabolic risk factors. However, this relation has been mainly studied in elderly and/or obese subjects. In addition, the relation between 25(OH)D and adiponectin is unclear. The purpose of this study is to look at these relations in non-obese young individuals. Design: We investigated the relation between serum 25(OH)D and adiposity, blood pressure, glucose metabolism, lipid profile, and adiponectin in 381 randomly selected university students (201 males and 180 females, mean age 23.9G3.9). Results: In the overall population, 25(OH)D is significantly inversely correlated with body mass index (BMI), systolic blood pressure (SBP), waist circumference (WC), fasting plasma glucose (FPG), insulin levels, and homeostasis model assessment of insulin resistance (HOMA index) and positively correlated with adiponectin and high density lipoprotein-cholesterol (P!0.01 for all variables). In males, these correlations are still significant for BMI, SBP, WC, and adiponectin (PZ0.02, PZ0.01, PZ0.04 and PZ0.01 respectively); also, 25(OH)D is inversely correlated with low density lipoprotein (LDL)-cholesterol (PZ0.007). In females, 25(OH)D is only inversely correlated with FPG and HOMA index (P!0.001 and PZ0.03 respectively). In multivariate regression analysis models, after adjustment for sex and BMI, 25(OH)D is an independent predictor of FPG and SBP (PZ0.032 and PZ0.05 respectively) in the overall population, while in males 25(OH)D is a predictor of LDL-cholesterol and SBP independently of BMI (PZ0.007 and PZ0.035 respectively). Conclusion: In non-obese young subjects, we observe new relationships between 25(OH)D and several metabolic risk factors and adiponectin. Further research is needed to elucidate the gender differences and to look at the relation between 25(OH)D and adiponectin.European Journal of Endocrinology 160 965-971

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Glucose tolerance and vitamin D: Effects of treating vitamin D deficiency

Cited by 99 publications

References 33 publications

Vitamin D and type 2 diabetes mellitus: Where do we stand?

Vitamin D and type 2 diabetes mellitus: Where do we stand?

Biochemical efficacy of vitamin D in ameliorating endocrine and metabolic disorders in diabetic rats

Vitamin D in relation to metabolic risk factors, insulin sensitivity and adiponectin in a young Middle-Eastern population

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