Glucose tolerance in adults after prenatal exposure to famine

Ravelli, Anita C.J.; Meulen, Jan van der; Michels, R. P. J.; Osmond, Clive; Barker, D. J. P.; Hales, C. N.; Bleker, O. P.

doi:10.1016/s0140-6736(97)07244-9

Cited by 1,446 publications

(1,020 citation statements)

References 30 publications

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“…A strand of recent work suggests that nutrition in utero can affect health status in middle age, through its impact on such important chronic conditions as coronary heart disease and diabetes (Barker, 1995;Ravelli et al, 1998). New experimental work finds that mice whose fetal growth is restricted, but who are fed well after birth, exhibit rapid catch-up growth but die significantly earlier than mice well fed in utero (Ozanne and Hales, 2004).…”

Section: Introductionmentioning

confidence: 99%

The lasting impact of childhood health and circumstance

Case

Fertig

Paxson

2005

Journal of Health Economics

1,339

1,054

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We quantify the lasting effects of childhood health and economic circumstances on adult health, employment and socioeconomic status, using data from a birth cohort that has been followed from birth into middle age. Controlling for parental income, education and social class, children who experience poor health have significantly lower educational attainment, poorer health, and lower social status as adults. Childhood health and circumstance appear to operate both through their impact on initial adult health and economic status, and through a continuing direct effect of prenatal and childhood health in middle age. Overall, our findings suggest more attention be paid to health as a potential mechanism through which intergenerational transmission of economic status takes place: cohort members born into poorer families experienced poorer childhood health, lower investments in human capital and poorer health in early adulthood, all of which are associated with lower earnings in middle age-the years in which they themselves become parents.

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Section: Introductionmentioning

confidence: 99%

The lasting impact of childhood health and circumstance

Case

Fertig

Paxson

2005

Journal of Health Economics

1,339

1,054

View full text Add to dashboard Cite

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“…starvation) in early stages of development has an impact on epigenetic markers later in life (36)(37)(38) , and is associated with increased risk of developing age-related diseases (e.g. CAD/myocardial infarct, obesity, hypertension and diabetes) (39)(40)(41)(42)(43)(44) .…”

Section: When Classic Twin Design Met New 'Omics'mentioning

confidence: 99%

Genomics of ageing in twins

Mangino

2014

Proc. Nutr. Soc.

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Ageing is a complex multifactorial process, reflecting the progression of all degenerative pathways within an organism. Due to the increase of life expectancy, in recent years, there is a pressing need to identify early-life events and risk factors that determine health outcomes in later life. So far, genetic variation only explains ~20–25 % of the variability of human survival to age 80+. This clearly implies that other factors (environmental, epigenetic and lifestyle) contribute to lifespan and the rate of healthy ageing within an individual. Twin studies in the past two decades proved to be a very powerful tool to discriminate the genetic from the environmental component. The aim of this review is to describe the basic concepts of the twin study design and to report some of the latest studies in which high-throughput technologies (e.g. genome/epigenome-wide assay, next generation sequencing, MS metabolic profiling) combined with the classical twin design have been applied to the analysis of novel ‘omics’ to further understand the molecular mechanisms of human ageing.

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“…The Dutch Hunger Winter was a short defined period of famine; therefore, it has been possible both to assess the role of early nutrition in future susceptibility to disease and to identify critical time windows (G.P. Ravelli et al, 1976;A.C. Ravelli et al, 1998).…”

Section: Periods Of Susceptibilitymentioning

confidence: 99%

“…Maternal smoking and poor nutrition during pregnancy are associated with reduced neonatal bone mineral content, presumably via effects on fetal nutrient supply and subsequent bone accretion . There is also direct evidence that poor maternal nutrition (Ravelli et al, 1998) and maternal smoking (Montgomery & Ekbom, 2002) cause both a reduction in birth weight and subsequent loss of glucose tolerance. Adult humans exposed to dioxins have increased risk of diabetes, hyperinsulinaemia, and abnormal glucose tolerance (Henriksen et al, 1997;Michalek et al, 1999).…”

Section: Consequences Of Exposuresmentioning

confidence: 99%

Expressing urine from a gel disposable diaper for biomonitoring using phthalates as an example

Liu

Xia

Guo

et al. 2012

J Expo Sci Environ Epidemiol

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The urinary metabolites of phthalates are well-accepted exposure biomarkers for adults and children older than 6 years but are not commonly used for infants owing to non-convenient sampling. In the light of this situation, a novel sampling method based on monitoring the urine expressed from the gel diaper was developed. The urine was expressed from the gel absorbent after mixing the absorbent with CaCl2 and then collected by a laboratory-made device; the urinary phthalate metabolites were extracted and cleaned using a solid-phase extraction (SPE) column and analyzed with high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry / mass spectrometry. To evaluate the method's feasibility, the following factors were investigated: the proportion of CaCl2 to gel absorbent, the urination volume variation and the target compounds' deposition bias in the diaper, the matrix blank of the different diaper brands, the storage stabilities and the recoveries of creatinine and phthalate metabolites in the expressed urine. Mono-methyl phthalate, mono-ethyl phthalate, mono-butyl phthalate, mono-benzyl phthalate, mono-2-ethylhexyl phthalate and mono-2-ethyl-5-oxohexyl phthalate were involved. 70-80% of the urine can be expressed from the diaper, and the expressed spiking recoveries and the limit of detection of mono-phthalates ranged from 88.5-115% and 0.21-0.50 ng/ml. The method was applied to measure phthalate metabolites in 65 gel diaper samples from 15 infants, and the pilot data suggests the infants are commonly exposed to phthalates. In summary, the method for monitoring of infant exposure to phthalates is sound and validated, and the potential health effects from the vulnerable infants' exposure to phthalates should be concerned.39th Scientific Research Foundation for the Returned Overseas Chinese Scholars (SRF for ROCS); Hundred Talent Program of Chinese Academy of Sciences (CAS); CAS/SAFEA International Partnership Program for Creative Research Teams [KZCX2-YW-T08

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Glucose tolerance in adults after prenatal exposure to famine

Cited by 1,446 publications

References 30 publications

The lasting impact of childhood health and circumstance

The lasting impact of childhood health and circumstance

Genomics of ageing in twins

Expressing urine from a gel disposable diaper for biomonitoring using phthalates as an example

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