Glucose tolerance of premenopausal women after menopause due to surgical removal of ovaries

Pirimoğlu, Zehra Meltem; Arslan, Cengiz; Büyükbayrak, Esra Eşim; Kars, Bülent; Karşıdağ, Yasemin Karageyım; Ünal, Orhan; Turan, Mehmet Cem

doi:10.3109/13697137.2010.539723

Cited by 30 publications

(16 citation statements)

References 20 publications

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“…Insulin resistance develops after OVX in rodents (48, 54) and menopause or hysterectomy in humans (12,36) via mechanisms that are incompletely understood but that likely involve increased accretion of WAT. In the current study, OVX caused a reduction in insulin sensitivity in LCR but not HCR rats.…”

Section: Discussionmentioning

confidence: 98%

Female rats selectively bred for high intrinsic aerobic fitness are protected from ovariectomy-associated metabolic dysfunction

Vieira‐Potter

Padilla

Park

et al. 2015

American Journal of Physiology-Regulatory, Integrative and Comp

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Ovariectomized rodents model human menopause in that they rapidly gain weight, reduce spontaneous physical activity (SPA), and develop metabolic dysfunction, including insulin resistance. How contrasting aerobic fitness levels impacts ovariectomy (OVX)-associated metabolic dysfunction is not known. Female rats selectively bred for high and low intrinsic aerobic fitness [high-capacity runners (HCR) and low-capacity runners (LCR), respectively] were maintained under sedentary conditions for 39 wk. Midway through the observation period, OVX or sham (SHM) operations were performed providing HCR-SHM, HCR-OVX, LCR-SHM, and LCR-OVX groups. Glucose tolerance, energy expenditure, and SPA were measured before and 4 wk after surgery, while body composition via dual-energy X-ray absorptiometry and adipose tissue distribution, brown adipose tissue (BAT), and skeletal muscle phenotype, hepatic lipid content, insulin resistance via homeostatic assessment model of insulin resistance and AdipoIR, and blood lipids were assessed at death. Remarkably, HCR were protected from OVX-associated increases in adiposity and insulin resistance, observed only in LCR. HCR rats were ∼30% smaller, had ∼70% greater spontaneous physical activity (SPA), consumed ∼10% more relative energy, had greater skeletal muscle proliferator-activated receptor coactivator 1-alpha, and ∼40% more BAT. OVX did not increase energy intake and reduced SPA to the same extent in both HCR and LCR. LCR were particularly affected by an OVX-associated reduction in resting energy expenditure and experienced a reduction in relative BAT; resting energy expenditure correlated positively with BAT across all animals (r = 0.6; P < 0.001). In conclusion, despite reduced SPA following OVX, high intrinsic aerobic fitness protects against OVX-associated increases in adiposity and insulin resistance. The mechanism may involve preservation of resting energy expenditure.

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Section: Discussionmentioning

confidence: 98%

Female rats selectively bred for high intrinsic aerobic fitness are protected from ovariectomy-associated metabolic dysfunction

Vieira‐Potter

Padilla

Park

et al. 2015

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Bilateral oophorectomy (BSO) abruptly decreases the production of estrogens, and is followed by post-glucose challenge hyperinsulinemia, implying insulin resistance (13). In rats, BSO decreased insulin-mediated glucose uptake via an impaired insulinstimulated translocation of GLUT4 to the plasma membrane (11,14) and decreased protein expression of glycogen synthase (14).…”

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confidence: 99%

Bilateral Oophorectomy and the Risk of Incident Diabetes in Postmenopausal Women

2014

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OBJECTIVEOvarian hormones regulate glucose uptake and insulin sensitivity. Despite the high frequency of surgical menopause, its relationship with diabetes has not been extensively investigated. We assessed the association between hysterectomy with or without bilateral oophorectomy (BSO) status, menopausal age, and reproductive life span with incident diabetes. RESEARCH DESIGN AND METHODSData were from a cohort of 2,597 postmenopausal women enrolled in the National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study without diabetes mellitus at baseline. Cox proportional hazards regression models were used to calculate adjusted hazard ratios (HRs) and 95% CIs. RESULTSAfter a median follow-up time of 9.2 years, the incidence of diabetes (in cases per 1,000 person-years) was 7.4 for women with no hysterectomy or BSO, 8.2 for hysterectomy alone, and 8.5 for hysterectomy with BSO. Hysterectomy status was associated positively with diabetes (HR 1.66, 95% CI 1.23-2.23). However, the elevated risk was restricted to women with both hysterectomy and BSO after adjustment for relevant confounders (HR 1.57, 95% CI 1.03-2.41). An earlier age at menopause and a shorter reproductive life span also exhibited a linear relationship with the development of diabetes irrespective of type of menopause (P for trend = 0.001). CONCLUSIONSWomen with hysterectomy concomitant with BSO may represent a unique population with elevated risk for diabetes and other chronic diseases. Therefore, the decision to remove the ovaries at the time of hysterectomy for benign conditions during the premenopausal years should be balanced with the risk of diabetes and its potential complications. Furthermore, the mechanism linking BSO to diabetes mellitus needs to be clarified.

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“…88,89 The prevalence of glucose intolerance (diabetes mellitus or impaired glucose tolerance) was 26% in women who had natural menopause. 47 Pirimoglu et al 90 reported that 17 of 30 women who had undergone oophorectomy developed glucose intolerance at the end of 12 months. 90 Therefore, surgical menopause may be more severe with regard to the risk for development of glucose intolerance.…”

Section: Discussionmentioning

confidence: 98%

“…47 Pirimoglu et al 90 reported that 17 of 30 women who had undergone oophorectomy developed glucose intolerance at the end of 12 months. 90 Therefore, surgical menopause may be more severe with regard to the risk for development of glucose intolerance. In contrast with natural menopause, women who underwent bilateral oophorectomy had a greater risk of developing CHD.…”

Section: Discussionmentioning

confidence: 98%

Amla (Emblica officinalis) extract is effective in preventing high fructose diet–induced insulin resistance and atherogenic dyslipidemic profile in ovariectomized female albino rats

Koshy

Bobby

et al. 2012

Menopause

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Glucose tolerance of premenopausal women after menopause due to surgical removal of ovaries

Abstract: The impairment of carbohydrate metabolism due to an abrupt decrease in natural estrogen levels should be considered before removing the ovaries during hysterectomy in premenopausal patients.

Cited by 30 publications

References 20 publications

Female rats selectively bred for high intrinsic aerobic fitness are protected from ovariectomy-associated metabolic dysfunction

Female rats selectively bred for high intrinsic aerobic fitness are protected from ovariectomy-associated metabolic dysfunction

Bilateral Oophorectomy and the Risk of Incident Diabetes in Postmenopausal Women

Amla (Emblica officinalis) extract is effective in preventing high fructose diet–induced insulin resistance and atherogenic dyslipidemic profile in ovariectomized female albino rats

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