Glucosyl Hesperidin Has an Anti-diabetic Effect in High-Fat Diet-Induced Obese Mice

Abstract

Glucosyl hesperidin (GH) is a water-soluble derivative of hesperidin, a citrus flavonoid. GH has various pharmacological effects, such as hypolipidemic and hypouricemic effects, and may therefore be a useful supplement or drug. In the present study, we evaluated the effects of long-and short-term intake of GH on hyperglycemia and macrophage infiltration into the adipose tissue of high-fat diet (HFD)-fed mice. Longterm (11-week) consumption of GH tended to reduce body weight and the fasting blood glucose concentration of the HFD-fed mice, and ameliorated glucose intolerance and insulin resistance, according to glucose and insulin tolerance tests. Additionally, although GH did not affect fat pad weight, it reduced HFD-induced macrophage infiltration into adipose tissue. Short-term (2-week) consumption of GH did not affect the HFDinduced increases in body weight or fasting blood glucose, and it did not ameliorate glucose intolerance or insulin resistance. However, short-term intake did reduce the HFD-induced macrophage infiltration and monocyte chemotactic protein 1 (MCP-1) expression in adipose tissue. Furthermore, hesperetin, which is an aglycone of GH, inhibited MCP-1 expression in 3T3-L1 adipocytes, 3T3-L1 adipocytes co-cultured with RAW264 macrophages, and tumor necrosis factor-α-treated 3T3-L1 adipocytes. The present findings suggest that daily consumption of GH may have preventive and/or therapeutic effects on obesity-related diseases, such as diabetes mellitus.

Computation Screening of Multi-Target Antidiabetic Properties of Phytochemicals in Common Edible Mediterranean Plants

“…Hesperidin is less distributed than rutin but is also a strong multi-target antidiabetic agent according to the computational measurements. These findings are in line with the literature; hesperidin is considered to have preventive and/or therapeutic effects against DM as it regulates glucose and lipid metabolism [170,171]. Overall, flavonoids are an interesting pool of antidiabetic compounds and further study is needed to probe the structural characteristics of flavonoids that are mainly linked with antidiabetic activity.…”

Hypolipidemic mechanism of Pleurotus eryngii polysaccharides in high-fat diet-induced obese mice based on metabolomics

“…The liver is the key site of lipid metabolism. The relative content of blood lipids in the human body is mainly regulated by hepatocytes, which convert cholesterol into bile acids and secrete bile to promote the digestion and absorption of fat in the intestine ( 52 , 53 ). When the liver function is damaged, the production and excretion of bile is hindered, resulting in abnormal lipid metabolism in the body.…”

Hesperidin from citrus peel waste: extraction and its health implications

“…A study by Kappel et al (2013) demonstrated that flavone glycosides enhance intracellular Ca 2+ concentration and inhibit the ionization of ATP-sensitive K + channels in pancreatic islets, a precursor to insulin synthesis. Long-term (11-week) consumption of growth hormone (GH) reduced body weight, fasting blood glucose concentration, glucose intolerance, and insulin resistance in mice fed an HFD (Yoshida et al, 2021). Furthermore, GH reduced macrophage infiltration into adipose tissue despite not affecting fat pad weight.…”