Glued versus stapled anastomosis of the colon: An experimental study to determine comparative resistance to intraluminal pressure

Paral, Jiri; Lochman, Petr; Blazej, Slavomir; Pavlik, Michal

doi:10.1016/j.asjsur.2014.01.007

Cited by 19 publications

(14 citation statements)

References 30 publications

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“…Although these differences were all statistically highly significant, the burst and leak pressures should be related to the actual intraluminal pressure that such a transection must withstand. Resting intraluminal pressures in small bowel and colon have been reported around 0 to 7 mmHg [21][22][23]. During intestinal pressure waves, the pressure may rise up to maximum levels of 50 mmHg in the physiological setting [21,23].…”

Section: Discussionmentioning

confidence: 98%

Evaluation of the LigaSure™ Vessel Sealing System for bowel transection and intestinal anastomosis—an experimental study in a porcine model

Gehrig

Billeter

Wekerle

et al. 2016

Langenbecks Arch Surg

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The LVSS achieves significantly lower burst pressures and anastomotic leak pressures for bowel transection and intestinal anastomosis than S and HS techniques. However, due to the achieved pressure levels of 39.8 ± 3.6 mmHg, LVSS appears to be a sufficient stand-alone method for bowel transection. Whether it can be used to perform intestinal anastomosis warrants further research in a survival model.

show abstract

Section: Discussionmentioning

confidence: 98%

Evaluation of the LigaSure™ Vessel Sealing System for bowel transection and intestinal anastomosis—an experimental study in a porcine model

Gehrig

Billeter

Wekerle

et al. 2016

Langenbecks Arch Surg

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show abstract

“…Our results of more than 60 Newton-this equals more than 6 kg force-are likely supraphysiologic, because experimental resection and reanastomosis models measured lower forces [2]. A criticism that is also valid for burst pressure [25]: resting pressures of porcine intestine were 47-fold lower than peak pressures of intact intestine and still 30-fold lower than stapled anastomoses [26].…”

Section: Commentmentioning

confidence: 66%

Esophageal Biomechanics Revisited: A Tale of Tenacity, Anastomoses, and Suture Bite Lengths in Swine

Sochaczewski

Lindner

Lang

et al. 2019

The Annals of Thoracic Surgery

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“…5 ). The macroscopic naked eye and endoscopic images observed correspond, according to the scientific literature, to the initial stages of hydrolytic degradation of the Glubran 2 film into water-soluble remains [ 19 , 22 ], which is a process that ends in a time ranging from 30–40 days to 6 months depending on the amount of sealant deposited and on the thickness of the sealant film [ 20 , 22 , 25 ]. Transmural inflammation and ulcerations were described at the histological examination of both types of ESDs, with no evidence of specific differences between the two (Fig.…”

Section: Resultsmentioning

confidence: 99%

Feasibility and safety of a new endoscopic synthetic sealant nebulizing device over gastric endoscopic submucosal dissections

et al. 2021

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Background Endoscopic Submucosal Dissection (ESD) is the treatment of choice of superficial neoplastic gastrointestinal lesions. Delayed bleedings and perforations are still current clinical concerns. Glubran 2 is a synthetic cyanoacrylate-derived glue nowadays already widely used as an effective tissue adhesive. ENDONEB is a novel device thought for enabling the sealant nebulization over a specific targeted surface during laparotomy, laparoscopy, and thoracotomy. The aim of this single-center preclinical animal trial is to evaluate the feasibility and safety of the same nebulization technique during ESD in the perspective that further clinical studies would demonstrate the efficacy of Glubran 2 in preventing post-ESD adverse events. Methods Four live Landrace pigs were enrolled. Two approximately 30-mm-wide gastric ESDs were performed in each pig (experimental ESD and control ESD). About 0.5 mL of Glubran 2 was nebulized on the experimental ESDs. Subjective perception of the feasibility of the Glubran 2 nebulization was reported. Pigs were clinically monitored at follow-up and upper GI endoscopy was performed at 24 and 48 hours, when animals were euthanized to perform a macroscopic and histological analysis of the specimens. Results No peri-procedural adverse events were reported. Glubran 2 nebulization over experimental ESDs showed to be technically easy and time-effective. Clinical and endoscopic animal monitoring was negative at follow-up. At 24 hours, the Glubran 2 film was clearly visible on the eschar of the ESDs and signs of initial hydrolysis were discernable at 48 hours. No signs of peritoneal reaction were observed at the macroscopic examination. Equal transmural inflammation was described at the histological examination of both types of ESDs. Conclusions Safety and feasibility profiles of Glubran 2 nebulizing ENDONEB device over ESD surfaces were excellent. Further evidences and human trials are needed to investigate its effectiveness in ESDs’ eschars sealing and, thus, in delayed micro-perforations and bleedings prevention and treatment.

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Glued versus stapled anastomosis of the colon: An experimental study to determine comparative resistance to intraluminal pressure

Abstract: Healing with absorbable synthetic glue was as good as with staples. Glued anastomoses resisted pressures that were statistically significantly higher than physiological intraluminal colon pressures but lower than stapled ones.

Cited by 19 publications

References 30 publications

Evaluation of the LigaSure™ Vessel Sealing System for bowel transection and intestinal anastomosis—an experimental study in a porcine model

Evaluation of the LigaSure™ Vessel Sealing System for bowel transection and intestinal anastomosis—an experimental study in a porcine model

Esophageal Biomechanics Revisited: A Tale of Tenacity, Anastomoses, and Suture Bite Lengths in Swine

Feasibility and safety of a new endoscopic synthetic sealant nebulizing device over gastric endoscopic submucosal dissections

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