Glut-1 as a prognostic biomarker in oral squamous cell carcinoma

Harshani, Jyotsna M; Yeluri, Sivaranjani; Guttikonda, Venkateswara Rao

doi:10.4103/0973-029x.151318

Cited by 27 publications

(17 citation statements)

References 19 publications

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“…An elevated expression of CA IX was associated with a poor prognosis of OSCC patients [ 59 ] and with a 5.13-fold increased risk of tumor-related death ( p = 0.017) [ 60 ]. This was confirmed by Li and coworkers, suggesting its use as a prognostic biomarker for this disease [ 61 , 62 , 63 ]. Thus, CA IX was established as an additive prognostic marker [ 45 , 64 ].…”

Section: Hif-1α Stabilization Under Normoxia Its Role In Glutaminsupporting

confidence: 59%

Current Understanding of the HIF-1-Dependent Metabolism in Oral Squamous Cell Carcinoma

Eckert

Kappler

Große

et al. 2020

IJMS

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Oral squamous cell carcinoma (OSCC) is the 10th most frequent human malignancy and is thus a global burden. Despite some progress in diagnosis and therapy, patients’ overall survival rate, between 40 and 55%, has stagnated over the last four decades. Since the tumor node metastasis (TNM) system is not precise enough to predict the disease outcome, additive factors for diagnosis, prognosis, prediction and therapy resistance are urgently needed for OSCC. One promising candidate is the hypoxia inducible factor-1 (HIF-1), which functions as an early regulator of tumor aggressiveness and is a key promoter of energy adaptation. Other parameters comprise the composition of the tumor microenvironment, which determines the availability of nutrients and oxygen. In our opinion, these general processes are linked in the pathogenesis of OSCC. Based on this assumption, the review will summarize the major features of the HIF system-induced activities, its target proteins and related pathways of nutrient utilization and metabolism that are essential for the initiation, progression and therapeutic stratification of OSCC.

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Section: Hif-1α Stabilization Under Normoxia Its Role In Glutaminsupporting

confidence: 59%

Current Understanding of the HIF-1-Dependent Metabolism in Oral Squamous Cell Carcinoma

Eckert

Kappler

Große

et al. 2020

IJMS

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“…Own investigations demonstrated a significant correlation between increased glucose uptake and poor prognosis in OSCC [ 49 ]. Similar results were obtained by Harshani [ 48 ]. In addition, the hypoxia linked upregulation of GLUT-1 was also described by Gimm and co-authors, which negatively interfered with the survival of OSCC patients [ 50 ].…”

Section: Tumor Hypoxia and Prognosis In Osccsupporting

confidence: 91%

“…The family of glucose transporter molecules summarizes 13 members [ 46 , 47 ]. The most investigated transport molecules in OSCC are HIF1 and GLUT-1 [ 41 , 48 ]. Own investigations demonstrated a significant correlation between increased glucose uptake and poor prognosis in OSCC [ 49 ].…”

Section: Tumor Hypoxia and Prognosis In Osccmentioning

confidence: 99%

Clinical relevance of the tumor microenvironment and immune escape of oral squamous cell carcinoma

et al. 2016

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BackgroundChanges in the tumor microenvironment and immune surveillance represent crucial hallmarks of various kinds of cancer, including oral squamous cell carcinoma (OSCC), and a close crosstalk of hypoxia regulating genes, an activation of chemokines and immune cells has been described.MethodsA review about the pivotal role of HIF-1, its crosstalk to various cornerstones in OSCC tumorigenesis is presented.ResultsHypoxia is a frequent event in OSCC and leads to a reprogramming of the cellular metabolism in order to prevent cell death. Hypoxic OSCC cells induce different adaptive changes such as anaerobic glycolysis, pH stabilisation and alterations of the gene and protein expression profile. This complex metabolic program is orchestrated by the hypoxia inducible factor (HIF)-1, the master regulator of early tumor progression. Hypoxia-dependent and -independent alterations in immune surveillance lead to different immune evasion strategies, which are partially mediated by alterations of the tumor cells, changes in the frequency, activity and repertoire of immune cell infiltrates and of soluble and environmental factors of the tumor micromilieu with consecutive generation of an immune escape phenotype, progression of disease and poor clinical outcome of OSCC patients.ConclusionsThis review focusses on the importance of HIF-1 in the adaption and reprogramming of the metabolic system to reduced oxygen values as well as on the role of the tumor microenvironment for evasion of OSCC from immune recognition and destruction.

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“…( P = 0.01). All 100% cases of Grade III cases showing intense staining which was in consonance with Harshani et al [13] Angadi et al [14] in their study on OSCC reported that 80% of well-differentiated OSCC showed mild staining which in consonance with our result where approximately 77% of Grade I OSCC showed mild staining intensity. There was an absence of GLUT 1 expression in the central keratinized area of keratin pearls suggesting the presence of differentiated mature cells in these areas [Figure 1].…”

Section: Discussionsupporting

confidence: 92%

“…Gender difference though present, with the male population being 69.7%, no statistically significant difference was observed. A higher predominance OSCC in male was in accordance with studies reported by Ayala et al [11] and Malhotra et al [12] In contrast, Harshani et al [13] reported a higher female predominance.…”

Section: Discussionsupporting

confidence: 90%

Can increased metabolic status be a grading tool for oral squamous cell carcinoma? A glucose transporter 1 immunoexpression study

et al. 2019

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Background:Glucose transporter-1 (GLUT-1) is a GLUT protein whose expression is upregulated in malignant cells where enhanced uptake of glucose is observed.Aim:The aim of this study is to evaluate the expression of GLUT-1 protein in oral squamous cell carcinoma (OSCC) tissue sections using immunohistochemistry and to describe the relationship between increased metabolic status and the grades of OSCC.Materials and Methods:This is cross-sectional study with 76 formalin-fixed paraffin-embedded tissue blocks of OSCC, obtained from the archives of the department. All the cases were scored using Bryne's grading system by three oral pathologists independently. The tissue sections were then stained using immunohistochemistry with anti-GLUT-1 rabbit monoclonal antibody.Results:Staining intensity and localization of positively stained slides were evaluated. Overall, a significant correlation between Bryne's histopathological grading system for OSCC and GLUT-1 immunohistochemical expression was observed. Thus, high GLUT-1 expressions are observed with increasing grades of OSCC.Conclusion:This study shows that a significant positive correlation exists between GLUT-1 immunoexpression and histological grading of OSCC. Thus, GLUT-1 expression can be used as a diagnostic adjunct and prognostic marker for OSCC patients.

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Glut-1 as a prognostic biomarker in oral squamous cell carcinoma

Cited by 27 publications

References 19 publications

Current Understanding of the HIF-1-Dependent Metabolism in Oral Squamous Cell Carcinoma

Current Understanding of the HIF-1-Dependent Metabolism in Oral Squamous Cell Carcinoma

Clinical relevance of the tumor microenvironment and immune escape of oral squamous cell carcinoma

Can increased metabolic status be a grading tool for oral squamous cell carcinoma? A glucose transporter 1 immunoexpression study

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