GLUT-1 est le récepteur des rétrovirus humains HTLV

Manel, Nicolas; Kinet, Sandrina; Kim, Felix J.; Taylor, Naomi; Sitbon, Marc; Battini, Jean-Luc

doi:10.1051/medsci/2004203277

Cited by 10 publications

(8 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…HTLV-1 preferentially infects cluster of differentiation 4 (CD4 + ) T cells, but cluster of differentiation 8 (CD8 + ) T cells, dendritic cells, macrophages and other cells are also infected by the virus [17][18][19][20] . The ubiquitous glucose transporter-1 (GLUT-1), neuropilin1 (NRP1) and surface heparan sulfate proteoglycans (HSPGs) function as receptors for cell invasion by the virus 21 . Once inside the cell, the virus integrates its DNA into chromosonal DNA.…”

Section: Structure Genome and Persistence Of The Htlv-1mentioning

confidence: 99%

Immunopathogenesis and neurological manifestations associated to HTLV-1 infection

Souza¹,

Tanajura

Toledo-Cornell

et al. 2012

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

The human T lymphotropic virus type-1 (HTLV-1) was the first human retrovirus identified. The virus is transmitted through sexual intercourse, blood transfusion, sharing of contaminated needles or syringes and from mother to child, mainly through breastfeeding. In addition to the well-known association between HTLV-1 and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), several diseases and neurologic manifestations have been associated with the virus. This review was conducted through a PubMed search of the terms HTLV-1, immune response and neurological diseases. Emphasis was given to the most recent data regarding pathogenesis and clinical manifestations of HTLV-1 infection. The aim of the review is to analyze the immune response and the variety of neurological manifestations associated to HTLV-1 infection. A total of 102 articles were reviewed. The literature shows that a large percentage of HTLV-1 infected individuals have others neurological symptoms than HAM/TSP. Increased understanding of these numerous others clinical manifestations associated to the virus than adult T cell leukemia/lymphoma (ATLL) and HAM/TSP has challenged the view that HTLV-1 is a low morbidity infection.

show abstract

Section: Structure Genome and Persistence Of The Htlv-1mentioning

confidence: 99%

Immunopathogenesis and neurological manifestations associated to HTLV-1 infection

Souza¹,

Tanajura

Toledo-Cornell

et al. 2012

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

show abstract

“…• L'ATL se caractérise par l'apparition de cellules T leucémiques ayant un noyau polylobé en forme de fleur [31]. Ces cellules expriment les marqueurs lymphocytaires CD2, CD3, CD4, CD5, CD45RO 4 .…”

Section: Pathologies Associées à L'infection Par Htlv-1unclassified

Leucémies T induites par HTLV-1

Dodon¹,

Mesnard²,

Barbeau³

2010

Med Sci (Paris)

View full text Add to dashboard Cite

“…Les cellules qui composent ces tissus possèdent, en plus des transporteurs ubiquitaires GLUT1 [14], un grand nombre de transporteurs, les GLUT4, qui se caractérisent principalement par leur localisation dans des compartiments intracellulaires. L'insuline qui est sécré-tée par les îlots pancréatiques après un repas induit une augmentation de GLUT4 à la surface des cellules ; ce qui permet la diminution des taux sanguins de glucose.…”

unclassified