GLUT1 is a highly efficient L-fucose transporter

Ng, Bobby G.; Sosicka, Paulina; Xia, Zhi‐Jie; Freeze, Hudson H.

doi:10.1016/j.jbc.2022.102738

Cited by 8 publications

(4 citation statements)

References 27 publications

(33 reference statements)

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“…1 A ). The free L-fucose concentration in human serum is rather low, at approximately 1.7 μM ( 7 ), and can only rise to 200 μM after excessive oral supplementation with L-fucose (100 mg/kg body weight), exceeding the rate of its rapid systemic degradation ( 11 ). These observations suggest that the L-fucose degradation pathway may serve to limit the presence of L-fucose in serum.…”

Section: Discussionmentioning

confidence: 99%

“…The de novo pathway transforms GDP-D-mannose to GDP-L-fucose through three enzymatic reactions catalyzed by two enzymes—GDP-D-mannose 4,6-dehydratase and bifunctional GDP-L-fucose synthase, whereas the fucose salvage pathway requires the activity of fucokinase (FCSK) and fucose-1-phosphate guanylyltransferase to generate GDP-D-fucose from free L-fucose derived from extracellular or lysosomal sources. Yet, virtually nothing is known about the mechanism behind the transport of L-fucose from the lysosomal lumen to the cytosol, whereas plasma membrane transporter GLUT1 has been recently identified as a highly efficient L-fucose transporter ( 7 ). Also, the biochemical importance of the existence of two distinct pathways for the biosynthesis of GDP-L-fucose in mammalian cells remains largely unclear.…”

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confidence: 99%

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Hydroxysteroid 17-β dehydrogenase 14 (HSD17B14) is an L-fucose dehydrogenase, the initial enzyme of the L-fucose degradation pathway

Witecka,

Kazak,

Kwiatkowski

et al. 2024

Journal of Biological Chemistry

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Hydroxysteroid 17-β dehydrogenase 14 (HSD17B14) is an L-fucose dehydrogenase, the initial enzyme of the L-fucose degradation pathway

Witecka,

Kazak,

Kwiatkowski

et al. 2024

Journal of Biological Chemistry

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“…In this study, the transcription of FoxO1 and its downstream targets, including PEPCK and G6Pase, were increased in both the C3 and C9 groups, suggesting a potential role of FoxO1 signaling pathway in regulating blood glucose homeostasis under cold stress. Furthermore, the expression of GLUT1, a member of the glucose transporter family, decreased continuously in the cardiac tissues of the C9 group, indicating an inhibition in glucose transport in vivo [42]. HK catalyzes the conversion of glucose to G6P, and further regulates other metabolic pathways, such as the pentose phosphate pathway to produce synthetic metabolic intermediates; therefore, variations in HK expression levels reflect glucose utilization [43].…”

Section: Discussionmentioning

confidence: 99%

Mild Intermittent Cold Stimulation Affects Cardiac Substance Metabolism via the Neuroendocrine Pathway in Broilers

Liu,

Xing,

Zhang

et al. 2023

Animals

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This study aimed to investigate the impact of cold adaptation on the neuroendocrine and cardiac substance metabolism pathways in broilers. The broilers were divided into the control group (CC), cold adaptation group (C3), and cold-stressed group (C9), and experimental period was divided into the training period (d 1–35), recovery period (d 36–43), and cold stress period (d 43–44). During the training period, the CC group was reared at ambient temperature, while C3 and C9 groups were reared at 3 °C and 9 °C lower than the ambient temperature, respectively, for 5 h/d at 1 d intervals. During the recovery period, all the groups were maintained at 20 °C. Lastly, during the cold stress period, the groups were divided into two sub-groups, and each sub-group was placed at 10 °C for 12 h (Y12) or 24 h (Y24) for acute cold stimulation. The blood, hypothalamic, and cardiac tissues samples were obtained from all the groups during the training, recovery, and acute stress periods. The results revealed that the transcription of calcium voltage-gated channel subunit alpha 1 C (CACNAIC) was increased in the hypothalamic tissues of the C3 group (p < 0.05). Moreover, compared to the CC group, the serum norepinephrine (NE) was increased in the C9 group (p < 0.05), but insulin (INS) was decreased in the C9 group (p < 0.05). In addition, the transcription of the phosphoinositide-3 kinase (PI3K), protein kinase B (Akt), mammalian target of rapamycin (mTOR), SREBP1c, FASN, ACC1, and SCD genes was down-regulated in the C3 and C9 groups (p < 0.05); however, their expression increased in the C3 and C9 groups after acute cold stimulation (p < 0.05). Compared to the CC group, the transcription of forkhead box O1 (FoxO1), PEPCK, G6Pase, GLUT1, HK1, PFK, and LDHB genes was up-regulated in the C3 and C9 groups (p < 0.05. Furthermore, compared to the CC and C9 groups, the protein and mRNA expressions of heat shock protein (HSP) 70 and HSP90 were significantly increased in the C3 group (p < 0.05). These results indicate that intermittent cold training can enhance cold stress tolerance in broilers by regulating their neuroendocrine and cardiac substance metabolism pathways.

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“…SLC37a2 encodes for a sugar transporter critical for bone metabolism and highlights the previously unappreciated plasticity of the osteoclasts’ specialized lysosome-related organelle(s) and can be a potential therapeutic target for metabolic bone diseases [ 15 ].…”

Section: Glutsmentioning

confidence: 99%

Relevance of Sugar Transport across the Cell Membrane

Carbó

Rodrı́guez

2023

IJMS

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Sugar transport through the plasma membrane is one of the most critical events in the cellular transport of nutrients; for example, glucose has a central role in cellular metabolism and homeostasis. The way sugars enter the cell involves complex systems. Diverse protein systems participate in the membrane traffic of the sugars from the extracellular side to the cytoplasmic side. This diversity makes the phenomenon highly regulated and modulated to satisfy the different needs of each cell line. The beautiful thing about this process is how evolutionary processes have diversified a single function: to move glucose into the cell. The deregulation of these entrance systems causes some diseases. Hence, it is necessary to study them and search for a way to correct the alterations and utilize these mechanisms to promote health. This review will highlight the various mechanisms for importing the valuable sugars needed to create cellular homeostasis and survival in all kinds of cells.

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GLUT1 is a highly efficient L-fucose transporter

Cited by 8 publications

References 27 publications

Hydroxysteroid 17-β dehydrogenase 14 (HSD17B14) is an L-fucose dehydrogenase, the initial enzyme of the L-fucose degradation pathway

Hydroxysteroid 17-β dehydrogenase 14 (HSD17B14) is an L-fucose dehydrogenase, the initial enzyme of the L-fucose degradation pathway

Mild Intermittent Cold Stimulation Affects Cardiac Substance Metabolism via the Neuroendocrine Pathway in Broilers

Relevance of Sugar Transport across the Cell Membrane

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