GLUT5 is a determinant of dietary fructose-mediated exacerbation of experimental colitis

Basu, Srijani; Liu, Catherine; Zhou, Xi Kathy; Nishiguchi, Ryohei; Ha, Taehoon; Johncilla, Melanie; Yantiss, Rhonda K.; Montrose, David C.; Dannenberg, Andrew J.

doi:10.1152/ajpgi.00059.2021

Cited by 11 publications

(6 citation statements)

References 36 publications

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“…Other applications include exploring the thanatomicrobiome, in determining the time elapsed since microbial death [ 56 ]. Further applications include tracking the microbiome before and after exposure to diseases like SARS COV2 [ 57 ], and determining changes in the microibial composition following dietary alterations [ 58 , 59 , 60 ].…”

Section: Discussionmentioning

confidence: 99%

Supervised Machine Learning Enables Geospatial Microbial Provenance

Bhattacharya

Tierney

Ryon

et al. 2022

Genes

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The recent increase in publicly available metagenomic datasets with geospatial metadata has made it possible to determine location-specific, microbial fingerprints from around the world. Such fingerprints can be useful for comparing microbial niches for environmental research, as well as for applications within forensic science and public health. To determine the regional specificity for environmental metagenomes, we examined 4305 shotgun-sequenced samples from the MetaSUB Consortium dataset—the most extensive public collection of urban microbiomes, spanning 60 different cities, 30 countries, and 6 continents. We were able to identify city-specific microbial fingerprints using supervised machine learning (SML) on the taxonomic classifications, and we also compared the performance of ten SML classifiers. We then further evaluated the five algorithms with the highest accuracy, with the city and continental accuracy ranging from 85–89% to 90–94%, respectively. Thereafter, we used these results to develop Cassandra, a random-forest-based classifier that identifies bioindicator species to aid in fingerprinting and can infer higher-order microbial interactions at each site. We further tested the Cassandra algorithm on the Tara Oceans dataset, the largest collection of marine-based microbial genomes, where it classified the oceanic sample locations with 83% accuracy. These results and code show the utility of SML methods and Cassandra to identify bioindicator species across both oceanic and urban environments, which can help guide ongoing efforts in biotracing, environmental monitoring, and microbial forensics (MF).

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Section: Discussionmentioning

confidence: 99%

Supervised Machine Learning Enables Geospatial Microbial Provenance

Bhattacharya

Tierney

Ryon

et al. 2022

Genes

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“…The western diet has been suggested to contribute to the rising incidence of inflammatory bowel diseases. A recent study reported that the interaction between fructose and its transporter, GLUT5, could shape the colonic microbiota and then impact the severity of CD [ 65 ]. Another studies showed that serum exosomes could circulate into the intestinal mucosa, regulating macrophage activation and epithelial barrier function to aggravate colitis [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

Stem cell therapy for Crohn’s disease: systematic review and meta-analysis of preclinical and clinical studies

et al. 2021

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Background We explored whether stem cell therapy was effective for animal models and patients with Crohn’s disease (CD). Methods We searched five online databases. The relative outcomes were analyzed with the aid of GetData Graph Digitizer 2.26 and Stata 16.0 software. The SYRCLE risk of bias tool and the MINORS tool were used to assess study quality. Results We evaluated 46 studies including 28 animal works (n = 567) and 18 human trials (n = 360). In the animal studies, the disease activity index dramatically decreased in the mesenchymal stem cell (MSC) treatment groups compared to the control group. Rats and mice receiving MSCs exhibited longer colons [mice: standardized mean difference (SMD) 2.84, P = 0.000; rats: SMD 1.44, P = 0.029], lower histopathological scores (mice: SMD − 4.58, p = 0.000; rats: SMD − 1.41, P = 0.000) and lower myeloperoxidase levels (SMD − 6.22, P = 0.000). In clinical trials, stem cell transplantation reduced the CD activity index (SMD − 2.10, P = 0.000), the CD endoscopic index of severity (SMD − 3.40, P = 0.000) and simplified endoscopy score for CD (SMD − 1.71, P = 0.000) and improved the inflammatory bowel disease questionnaire score (SMD 1.33, P = 0.305) compared to control values. CD patients maintained high remission rates for 3–24 months after transplantation. Conclusions Stem cell transplantation is a valuable supplementary therapy for CD.

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“…One of the reasons is that high fructose diet feeding can reduce the thickness of colonic mucus and alter the composition and metabolism of the gut microbiota [110] . In a recent study, SLC2A5 +/+ and SLC2A5 –/– mice fed with a 15 Kcal% fructose diet were found to exhibit more severe DSS-induced experimental colitis [111] . This effect is associated with increased level of free fructose in the colon and changes in the fecal microbiota in SLC2A5 –/– mice, and broad-spectrum antibiotics can prevent the worsening of colitis in SLC2A5 –/– mice [111] .…”

Section: Relationship Between Glut5 and Intestinal Diseasesmentioning

confidence: 93%

“…In a recent study, SLC2A5 +/+ and SLC2A5 –/– mice fed with a 15 Kcal% fructose diet were found to exhibit more severe DSS-induced experimental colitis [111] . This effect is associated with increased level of free fructose in the colon and changes in the fecal microbiota in SLC2A5 –/– mice, and broad-spectrum antibiotics can prevent the worsening of colitis in SLC2A5 –/– mice [111] . This is consistent with the conclusion that changes in GLUT5 expression lead to changes in the gut microbiota, as mentioned earlier.…”

Section: Relationship Between Glut5 and Intestinal Diseasesmentioning

confidence: 93%

GLUT5: structure, functions, diseases and potential applications

Song¹,

Mao²,

Wei³

2023

ABBS

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Glucose transporter 5 (GLUT5) is a membrane transporter that specifically transports fructose and plays a key role in dietary fructose uptake and metabolism. In recent years, a high fructose diet has occupied an important position in the daily intake of human beings, resulting in a significant increase in the incidence of obesity and metabolic diseases worldwide. Over the past few decades, GLUT5 has been well understood to play a significant role in the pathogenesis of human digestive diseases. Recently, the role of GLUT5 in human cancer has received widespread attention, and a large number of studies have focused on exploring the effects of changes in GLUT5 expression levels on cancer cell survival, metabolism and metastasis. However, due to various difficulties and shortcomings, the molecular structure and mechanism of GLUT5 have not been fully elucidated, which to some extent prevents us from revealing the relationship between GLUT5 expression and cell carcinogenesis at the protein molecular level. In this review, we summarize the current understanding of the structure and function of mammalian GLUT5 and its relationship to intestinal diseases and cancer and suggest that GLUT5 may be an important target for cancer therapy.

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GLUT5 is a determinant of dietary fructose-mediated exacerbation of experimental colitis

Cited by 11 publications

References 36 publications

Supervised Machine Learning Enables Geospatial Microbial Provenance

Supervised Machine Learning Enables Geospatial Microbial Provenance

Stem cell therapy for Crohn’s disease: systematic review and meta-analysis of preclinical and clinical studies

GLUT5: structure, functions, diseases and potential applications

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