2016
DOI: 10.18863/pgy.253445
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Glutamat Sistemi ve Şizofreni

Abstract: ÖzGlutamat santral sinir sisteminin ana uyarıcı nörotransmitteridir. Glutamat öğrenme, bellek ve algı gibi birçok bilişsel fonksiyonlarda görev alır. Glutamat beyin gelişiminde, nöronal göçte, nöronal farklılaşmada, akson oluşumunda ve nöronal yaşamında önemli görev almaktadır. Glutamat birçok nörodejeneratif hastalıkta görülen eksitotoksisite ile ilişkilendirilmektedir. Şizofreni patogenezinde glutamat disfonksiyonun katkısı olduğunu düşündüren birçok kanıt bulunmaktadır. Fensiklidin ve ketamin gibi NMDA rese… Show more

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Cited by 3 publications
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“…Glutamate, the brain's principal excitatory neurotransmitter, contributes to learning and memory processes, brain development, neuronal life, neuronal differentiation, neuronal migration, and axon formation [30]. Changes in glutamatergic neurotransmission have been proposed to have an essential role in the pathophysiology of depression.…”
Section: Glutamatergic Systemmentioning
confidence: 99%
“…Glutamate, the brain's principal excitatory neurotransmitter, contributes to learning and memory processes, brain development, neuronal life, neuronal differentiation, neuronal migration, and axon formation [30]. Changes in glutamatergic neurotransmission have been proposed to have an essential role in the pathophysiology of depression.…”
Section: Glutamatergic Systemmentioning
confidence: 99%