Glutamate agonist causes irreversible degeneration of inner hair cells

Hyodo, Jun; Hakuba, Nobuhiro; Hato, Naohito; Takeda, Shoichirou; Okada, Masahiro; Omotehara, Yoshinori; Gyo, Kiyofumi

doi:10.1097/wnr.0b013e32833017ce

Cited by 13 publications

(6 citation statements)

References 18 publications

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“…There have been reports showing glutamate cytotoxicity in hair cells [10,14] and one report suggested the aggravating actions of glutamate released from deteriorating hair cells, which supports our hypothesis [15]. This mechanism will also contribute to SGC destruction, which has been reported in homozygous (cir/cir) mice [4,12,13].…”

Section: Discussionsupporting

confidence: 86%

Vesicular glutamate transporter 3 is strongly upregulated in cochlear inner hair cells and spiral ganglion cells of developing circling mice

Lee

Kim

Ahn

2015

Neuroscience Letters

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Section: Discussionsupporting

confidence: 86%

Vesicular glutamate transporter 3 is strongly upregulated in cochlear inner hair cells and spiral ganglion cells of developing circling mice

Lee

Kim

Ahn

2015

Neuroscience Letters

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“…This treatment resulted in swelling of lateral-line afferent nerve terminals. This swelling was similar to what has been reported in mammal auditory system after AMPA exposure ( Puel et al, 1994 ; Hyodo et al, 2009 ). Functional calcium imaging revealed a loss of activity in afferent nerve terminals after this treatment.…”

Section: Noise Exposure Excitoxicity and Acquired Hearing Loss In Zesupporting

confidence: 91%

“…Subsequently, the afferent terminals swell and, in the case of KA application on auditory hair-cell explants, neurites retract ( Wang and Green, 2011 ). In cases of AMPA administration to inner ears, a small but significant percentage of inner hair cells are also lost 7 days following exposure ( Hakuba et al, 2003 ; Hyodo et al, 2009 ). Two recent pharmacological studies have used iGluR agonists to mimic noise exposure in zebrafish larvae.…”

Section: Noise Exposure Excitoxicity and Acquired Hearing Loss In Zementioning

confidence: 99%

Transmission Disrupted: Modeling Auditory Synaptopathy in Zebrafish

Kindt

Sheets

2018

Front. Cell Dev. Biol.

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Sensorineural hearing loss is the most common form of hearing loss in humans, and results from either dysfunction in hair cells, the sensory receptors of sound, or the neurons that innervate hair cells. A specific type of sensorineural hearing loss, referred to as auditory synaptopathy, occurs when hair cells are able to detect sound but fail to transmit sound stimuli at the hair-cell synapse. Auditory synaptopathy can originate from genetic alterations that specifically disrupt hair-cell synapse function. Additionally, environmental factors such as noise exposure can leave hair cells intact but result in loss of hair-cell synapses, and represent an acquired form of auditory synaptopathy. The zebrafish model has emerged as a valuable system for studies of hair-cell function, and specifically hair-cell synaptopathy. In this review, we describe the experimental tools that have been developed to study hair-cell synapses in zebrafish. We discuss how zebrafish genetics has helped identify and define the roles of hair-cell synaptic proteins crucial for hearing in humans, and highlight how studies in zebrafish have contributed to our understanding of hair-cell synapse formation and function. In addition, we also discuss work that has used noise exposure or pharmacological mimic of noise-induced excitotoxicity in zebrafish to define cellular mechanisms underlying noise-induced hair-cell damage and synapse loss. Lastly, we highlight how future studies in zebrafish could enhance our understanding of the pathological processes underlying synapse loss in both genetic and acquired auditory synaptopathy. This knowledge is critical in order to develop therapies that protect or repair auditory synaptic contacts.

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“…There may be species-differences in the susceptibility of the hair cells to excitotoxic damage. For instance, in the rat, the hair cells were unscathed by the kainate insult (Juiz et al, 1989) but in the gerbil, the glutamate agonist AMPA was found to induce IHC death at high concentrations (Hyodo et al, 2009).…”

Section: Glutamatergic Excitotoxicitymentioning

confidence: 99%

The use of animal models to study cell transplantation in neuropathic hearing loss

Abbas

Rivolta

2019

Hearing Research

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Auditory neuropathy (AN) is a form of sensorineural deafness specifically affecting the conduction of the nerve impulse from the cochlear hair cells to the auditory centres of the brain. As such, the condition is a potential clinical target for 'cell replacement therapy', in which a functioning auditory nerve is regenerated by transplanting an appropriated neural progenitor. In this review, we survey the current literature and examine possible experimental models for this condition, with particular reference to their compatibility as suitable hosts for transplantation. The use of exogenous neurotoxic agents such as ouabain or β-bungarotoxin is discussed, as are ageing and noise-induced synaptopathy models. Lesioning of the nerve by mechanical damage during surgery and the neuropathy resulting from infectious diseases may be very relevant clinically, and we discuss whether there are good models for these situations. We also address genetic models for AN, examining whether the phenotypes truly model the clinical situation in their human counterpart syndromes-we use the example of the hyperbilirubinaemic Gunn rat as a particular instance in this regard.

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Glutamate agonist causes irreversible degeneration of inner hair cells

Cited by 13 publications

References 18 publications

Vesicular glutamate transporter 3 is strongly upregulated in cochlear inner hair cells and spiral ganglion cells of developing circling mice

Vesicular glutamate transporter 3 is strongly upregulated in cochlear inner hair cells and spiral ganglion cells of developing circling mice

Transmission Disrupted: Modeling Auditory Synaptopathy in Zebrafish

The use of animal models to study cell transplantation in neuropathic hearing loss

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