Glutamate Cotransmission in Cholinergic, GABAergic and Monoamine Systems: Contrasts and Commonalities

Trudeau, Louis-Éric; Mestikawy, Salah El

doi:10.3389/fncir.2018.00113

Cited by 72 publications

(80 citation statements)

References 114 publications

(186 reference statements)

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“…The ability of ChIs to release other neurotransmitters like glutamate, in addition to ACh itself, has been increasingly described in recent reviews (Kljakic et al, 2017;Mestikawy et al, 2011;Trudeau and Mestikawy, 2018) In this review, we discuss the long-standing model that DA and ACh oppose one another. There are still compelling evidence of opposite effects of these two neurotransmitters in striatal microcircuitry regulation.…”

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confidence: 99%

Contribution of cholinergic interneurons to striatal pathophysiology in Parkinson's disease

Ztaou

Amalric

2019

Neurochemistry International

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Parkinson's disease (PD) is a neurodegenerative disorder caused by the loss of nigral dopaminergic neurons innervating the striatum, the main input structure of the basal ganglia. This creates an imbalance between dopaminergic inputs and cholinergic interneurons (ChIs) within the striatum. The efficacy of anticholinergic drugs, one of the earliest therapy for PD before the discovery of L-3,4-dihydroxyphenylalanine (L-DOPA) suggests an increased cholinergic tone in this disease. The dopamine (DA)-acetylcholine (ACh) balance hypothesis is now revisited with the use of novel cutting-edge techniques (optogenetics, pharmacogenetics, new electrophysiological recordings). This review will provide the background of the specific contribution of ChIs to striatal microcircuit organization in physiological and pathological conditions. The second goal of this review is to delve into the respective contributions of nicotinic and muscarinic receptor cholinergic subunits to the control of striatal afferent and efferent neuronal systems. Special attention will be given to the role played by muscarinic acetylcholine receptors (mAChRs) in the regulation of striatal network which may have important implications in the development of novel therapeutic strategies for motor and cognitive impairment in PD.

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confidence: 99%

Contribution of cholinergic interneurons to striatal pathophysiology in Parkinson's disease

Ztaou

Amalric

2019

Neurochemistry International

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“…Aside from these major sources of glutamatergic input, midbrain dopamine (DA) neurons co‐release glutamate in the OT (Mingote et al, ; Wieland et al, ). Glutamate co‐release also likely occurs from cholinergic interneurons (CINs) and brainstem serotonergic neurons (Gras et al, ; Trudeau & El Mestikawy, ), but the functional role for this in the OT is not known.…”

Section: Glutamatementioning

confidence: 99%

“…Glutamate co-release also likely occurs from cholinergic interneurons (CINs) and brainstem serotonergic neurons (Gras et al, 2002;Trudeau & El Mestikawy, 2018), but the functional role for this in the OT is not known.…”

Section: Sources Of Glutamate In the Otmentioning

confidence: 99%

“…VGLUT3 is not expressed as widely throughout the brain, but is nevertheless seen at high levels in the OT, with the highest levels of expression in layers 1 and 3 (Herzog et al, 2004). Interestingly, VGLUT3 is co-expressed with acetylcholine (ACh) and serotonin (5-HT) transporters in the striatum, suggesting that some CINs in the striatum and serotonergic brainstem neurons may co-release glutamate (Gras et al, 2002;Trudeau & El Mestikawy, 2018). (Mingote et al, 2015), in contrast to CINs which included an NMDAR component (Wieland et al, 2014).…”

Section: Glutamate Transporters In the Otmentioning

confidence: 99%

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Neurochemical organization of the ventral striatum’s olfactory tubercle

Cansler

Wright

Stetzik

et al. 2020

Journal of Neurochemistry

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The ventral striatum is a collection of brain structures, including the nucleus accumbens, ventral pallidum and the olfactory tubercle (OT). While much attention has been devoted to the nucleus accumbens, a comprehensive understanding of the ventral striatum and its contributions to neurological diseases requires an appreciation for the complex neurochemical makeup of the ventral striatum's other components. This review summarizes the rich neurochemical composition of the OT, including the neurotransmitters, neuromodulators and hormones present. We also address the receptors and transporters involved in each system as well as their putative functional roles. Finally, we end with briefly reviewing select literature regarding neurochemical changes in the OT in the context of neurological disorders, specifically neurodegenerative disorders. By overviewing the vast literature on the neurochemical composition of the OT, this review will serve to aid future research into the neurobiology of the ventral striatum.

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“…The potency and valence of this ACh mediated impact on MSNs has been highly debated, possibly subsets of cholinergic neurons have potent effects depending upon the combination transmitter corelease (Trudeau & El Mestikawy, 2018). The impact of neocortical ablations on locally evoked synaptic potentials of MSNs has been explored in detail .…”

Section: Effec Ts Of Corti C Al Damag E On S Tr I Ata L Ac Ti V It Ymentioning

confidence: 99%

Translating striatal activity from brain slice to whole animal neurophysiology: A guide for neuroscience research integrating diverse levels of analysis

Cromwell

2019

J of Neuroscience Research

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An important goal of this review is highlighting research in neuroscience as examples of multilevel functional and anatomical analyses addressing basic science issues and applying results to the understanding of diverse disorders. The research of Dr. Michael Levine, a leader in neuroscience, exemplifies this approach by uncovering fundamental properties of basal ganglia function and translating these findings to clinical applications. The review focuses on neurophysiological research connecting results from in vitro and in vivo recordings. A second goal is to utilize these research connections to produce novel, accurate descriptions for corticostriatal processing involved in varied, complex functions. Medium spiny neurons in striatum act as integrators combining input with baseline activity creating motivational “events.” Basic research on corticostriatal synapses is described and links developed to issues with clinical relevance such as inhibitory gating, self‐injurious behavior, and relative reward valuation. Work is highlighted on dopamine–glutamate interactions. Individual medium spiny neurons express both D1 and D2 receptors and encode information in a bivalent manner depending upon the mix of receptors involved. Current work on neurophysiology of reward processing has taken advantage of these basic approaches at the cellular and molecular levels. Future directions in studying physiology of reward processing and action sequencing could profit by incorporating the divergent ways dopamine modulates incoming neurochemical signals. Primary investigators leading research teams should mirror Mike Levine's efforts in “climbing the mountain” of scientific inquiry by performing analyses at different levels of inquiry, integrating the findings, and building comprehensive answers to problems unsolvable without this bold approach.

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Glutamate Cotransmission in Cholinergic, GABAergic and Monoamine Systems: Contrasts and Commonalities

Cited by 72 publications

References 114 publications

Contribution of cholinergic interneurons to striatal pathophysiology in Parkinson's disease

Contribution of cholinergic interneurons to striatal pathophysiology in Parkinson's disease

Neurochemical organization of the ventral striatum’s olfactory tubercle

Translating striatal activity from brain slice to whole animal neurophysiology: A guide for neuroscience research integrating diverse levels of analysis

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