Glutamate Mechanisms Underlying Opiate Memories

Peters, Jamie; Vries, Taco J. De

doi:10.1101/cshperspect.a012088

Cited by 47 publications

(22 citation statements)

References 125 publications

(178 reference statements)

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“…Additionally, the present findings indicate that MEGR inhibited METH-induced CPP by interfering with METH cue-associated memory, which is independent of GABAb receptors and implicates the involvement of other neurotransmitters. Given that glutamatergic receptors are critical in drug-cue associated memory processes [ 30 ] and that both isoliquiritigenin and glycyrrhizic acid antagonize the electrophysiological function of N-methyl-D-aspartate (NMDA) receptors to inhibit Ca2+ influx [ 31 , 32 ], the glutamatergic system in the brain may be another important target for G. radix when treating METH addiction.…”

Section: Discussionmentioning

confidence: 99%

Glycyrrhizae Radix Methanol Extract Attenuates Methamphetamine‐Induced Locomotor Sensitization and Conditioned Place Preference

Zhao

Kim

Yang

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Glycyrrhizae Radix modulates the neurochemical and locomotor alterations induced by acute psychostimulants in rodents via GABAb receptors. This study investigated the influence of methanol extract from Glycyrrhizae Radix (MEGR) on repeated methamphetamine- (METH-) induced locomotor sensitization and conditioned place preference (CPP). A cohort of rats was treated with METH (1 mg/kg/day) for 6 consecutive days, subjected to 6 days of withdrawal, and then challenged with the same dose of METH to induce locomotor sensitization; during the withdrawal period, the rats were administered MEGR (60 or 180 mg/kg/day). A separate cohort of rats was treated with either METH or saline every other day for 6 days in METH-paired or saline-paired chambers, respectively, to induce CPP. These rats were also administered MEGR (180 mg/kg) prior to every METH or CPP expression test. Pretreatment with MEGR (60 and 180 mg/kg/day) attenuated the expression of METH-induced locomotor sensitization dose-dependently, and 180 mg/kg MEGR significantly inhibited the development and expression of METH-induced CPP. Furthermore, administration of a selective GABAb receptor antagonist (SCH50911) prior to MEGR treatment effectively blocked the inhibitory effects of MEGR on locomotor sensitization, but not CPP. These results suggest that Glycyrrhizae Radix blocked repeated METH-induced behavioral changes via GABAb receptors.

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Section: Discussionmentioning

confidence: 99%

Glycyrrhizae Radix Methanol Extract Attenuates Methamphetamine‐Induced Locomotor Sensitization and Conditioned Place Preference

Zhao

Kim

Yang

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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“…It has been established that extinction learning and memory involves the interaction of the amygdala, medial prefrontal cortex (mPFC) and the hippocampus (Quirk and Mueller, ). Reciprocal anatomical projections between the mPFC, amygdala and the hippocampus appear to utilize glutamate as a primary neurotransmitter (Del Arco and Mora, ; Peters and De Vries, ). NMDA receptors (see Alexander et al ., ) have been shown to be involved in extinction learning and memory (Myers et al ., ).…”

Section: Introductionmentioning

confidence: 98%

Dorsal hippocampal NMDA receptor blockade impairs extinction of naloxone‐precipitated conditioned place aversion in acute morphine‐treated rats by suppressing ERK and CREB phosphorylation in the basolateral amygdala

Wang

Chen

et al. 2014

British J Pharmacology

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Background and Purpose Substantial evidence shows that negative reinforcement resulting from the aversive affective consequences of opiate withdrawal may play a crucial role in drug relapse. Understanding the mechanisms underlying the loss (extinction) of conditioned aversion of drug withdrawal could facilitate the treatment of drug addiction. Experimental Approach Naloxone‐induced conditioned place aversion (CPA) of Sprague‐Dawley rats was used to measure conditioned aversion. An NMDA receptor antagonist and MAPK kinase inhibitor were applied through intracranial injections. The phosphorylation of ERK and cAMP response element‐binding protein (CREB) was detected using Western blot. Key Results The extinction of CPA behaviour increased the phosphorylation of ERK and CREB in the dorsal hippocampus (DH) and basolateral amygdala (BLA), but not in the central amygdala (CeA). Intra‐DH injection of AP5 or intra‐BLA injection of AP‐5 or U0126 before extinction training significantly attenuated ERK and CREB phosphorylation in the BLA and impaired the extinction of CPA behaviour. Although intra‐DH injections of AP‐5 attenuated extinction training‐induced activation of the ERK‐CREB pathway in the BLA, intra‐BLA injection of AP5 had no effect on extinction training‐induced activation of the ERK‐CREB pathway in the DH. Conclusions and Implications These results suggest that activation of ERK and CREB in the BLA and DH is involved in the extinction of CPA behaviour and that the DH, via a direct or indirect pathway, modulates the activity of ERK and CREB in the BLA through activation of NMDA receptors after extinction training. Understanding the mechanisms underlying the extinction of conditioned aversion could facilitate the treatment of drug addiction. Linked Articles This article is part of a themed section on Opioids: New Pathways to Functional Selectivity. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2015.172.issue-2

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“…Pharmacological approaches may enhance the efficacy of CET and one particularly promising compound is D -cycloserine ( D -4-amino-3-isoxazolidone; DCS), an antibiotic medication that is also a partial agonist at the glycine modulatory site at the glutamatergic N -methyl- D -aspartate (NMDA) receptor. NMDA receptors play a critical role in learning and memory 16 , 17 and DCS may enhance salutary new learning during therapeutic extinction. This possibility has been most extensively investigated in augmenting treatment for anxiety disorders.…”

Section: Introductionmentioning

confidence: 99%

D-cycloserine to enhance extinction of cue-elicited craving for alcohol: a translational approach

et al. 2015

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Cue-elicited craving for alcohol is well established but extinction-based treatment to extinguish this response has generated only modest positive outcomes in clinical trials. Basic and clinical research suggests that D-cycloserine (DCS) enhances extinction to fear cues under certain conditions. However, it remains unclear whether DCS would also accelerate extinction of cue-elicited craving for alcohol. The goal of the current study was to examine whether, compared with placebo (PBO), DCS enhanced extinction of cue-elicited craving among treatment-seeking individuals with alcohol use disorders (AUDs). Participants were administered DCS (50 mg) or PBO 1 h before an alcohol extinction paradigm in a simulated bar environment on two occasions. The extinction procedures occurred 1 week apart and were fully integrated into outpatient treatment. Subjective craving for alcohol was the primary variable of interest. Follow-up cue reactivity sessions were conducted 1 week and 3 weeks later to ascertain persisting DCS effects. Drinking outcomes and tolerability were also examined. DCS was associated with augmented reductions in alcohol craving to alcohol cues during the first extinction session and these effects persisted through all subsequent sessions, suggesting facilitation of extinction. Participants in the DCS condition reported significant short-term reductions in drinking, although these did not persist to follow-up, and found the medication highly tolerable. These findings provide evidence that DCS enhances extinction of cue-elicited craving for alcohol in individuals with AUDs in the context of outpatient treatment. The potential clinical utility of DCS is discussed, including methodological considerations and context-dependent learning.

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Glutamate Mechanisms Underlying Opiate Memories

Cited by 47 publications

References 125 publications

Glycyrrhizae Radix Methanol Extract Attenuates Methamphetamine‐Induced Locomotor Sensitization and Conditioned Place Preference

Glycyrrhizae Radix Methanol Extract Attenuates Methamphetamine‐Induced Locomotor Sensitization and Conditioned Place Preference

Dorsal hippocampal NMDA receptor blockade impairs extinction of naloxone‐precipitated conditioned place aversion in acute morphine‐treated rats by suppressing ERK and CREB phosphorylation in the basolateral amygdala

D-cycloserine to enhance extinction of cue-elicited craving for alcohol: a translational approach

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