Glutamate sensing with enzyme-modified floating-gate field effect transistors

A Glass Capillary-Based Microsensor for L-Glutamate in in Vitro Uses

“…The lower detection limit for L-glutamate of GluOx-based sensors has been reported to be sub-M or better. The detection limit of nM range has also been reported (Tang, et al, 2007;Braeken et al, 2009). However, these values are based on the measurements in an electrolyte solution rather than in brain or brain tissues.…”

A novel method for simultaneous glutamate and extracellular activity measurement in brain slices with high temporal resolution

“…Microelectrode array including the sentinel electrodes are now available with a highly technical biosensor process, although they cannot be constructed in the most of the laboratories regarding dissemination of the use of this method [30]. Although the present method still does not reach a high sensitivity (1.0 µM), it could be an important starting to develop alternative detection systems in order to measure other neurotransmitters with improved sensitivity, such as luminescence or electrochemiluminescence, which could increase at least two 15 magnitude orders the limit of detection. The reproducibility can be considered good enough, since at different experiments sessions carried out the calibration curves were similar in their linear regression analysis and the fluoresce intensity found for each standard of Glu.…”

“…Currently, biosensor technology has proven to be a very promising progressive analytical tool capable of performing quick and selective detection of Glu [15]. However, the main problem with the biosensors is interference.…”

Effective Area Effects on the Final Device Sensitivity of Ion Sensor Transducers

“…ISFET devices have proven to be promising tools in various Jessica Colnaghi Fernandes jessicacf@pg.ffclrp.usp.br 1 Universidade de São Paulo, Av. Bandeirantes, 3900 Ribeirão Preto, SP, Brazil research domains, including DNA genotyping, food screening, and multi-analyte detection for biomedical applications [3] and [4]. Many chemical and biological processes depend on one of the commonest laboratory measurements-the pH value [5] and [6].…”