Glutamatergic involvement in psychomotor stimulant action

Rockhold, Robin W.

doi:10.1007/978-3-0348-8833-2_4

Cited by 30 publications

(20 citation statements)

References 188 publications

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“…Future work in this area of investigation may incorporate microsensor technology, which may be more sensitive than microdialysis to neuronally-derived glutamate (Oldenziel et al, 2006). It is known that the NAcc and related neural pathways are involved in the psychostimulant effects of amphetamine (Wolf, 1998;Rockhold et al, 1998;Wolf et al, 2004;Kalivas and Volkow, 2005). Neuroanatomical studies have indicated that DA neurons in the NAcc receive significant glutamatergic input directly from the limbic cortex and sub-cortical structures (Groenewegen et al 1980;Kelley and Domesick 1982;Kita and Kitai 1990;Parent and Hazrati, 1995;Sesack et al, 1989;Tzschentke and Schmidt, 2000).…”

Section: Discussionmentioning

confidence: 99%

Environmental enrichment increases amphetamine-induced glutamate neurotransmission in the nucleus accumbens: A neurochemical study

Rahman

Bardo

2008

Brain Research

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In addition to dopamine (DA), evidence indicates that glutamatergic regulation of the mesolimbic reward pathway is involved in mediating the abuse-related effects of psychostimulants, including amphetamine. Since rats raised in an enrichment condition (EC) during development are more sensitive to the locomotor stimulant effects of acute amphetamine compared to rats raised in an impoverished condition (IC), the present study examined amphetamine-induced extracellullar glutamate and aspartate levels in the nucleus accumbens (NAcc) of EC and IC rats using in vivo microdialysis coupled with HPLC-electrochemical detection. Basal extracellular levels of glutamate or aspartate were not significantly different between EC and IC rats. Acute systemic amphetamine (0.5 or 2.0 mg/kg, sc) increased extracellular glutamate levels in NAcc of EC rats (137% or 305% of basal) and IC rats (120% or 187% of basal). Similarly, acute systemic amphetamine (0.5 or 2.0 mg/kg, sc) elevated aspartate levels in NAcc of EC rats (148% or 237% of basal) and IC rats (115% or 170% of basal). Glutamate levels were elevated by amphetamine to a greater extent in EC rats than in IC rats. Pretreatment with systemic MK-801 (0.25 mg/kg, ip), a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, prevented the acute amphetamine-induced increase in extracellular glutamate and aspartate levels in NAcc. Overall, these results suggest that alterations in glutamate in the NAcc may be involved in the environment-dependent effects of amphetamine.

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Section: Discussionmentioning

confidence: 99%

Environmental enrichment increases amphetamine-induced glutamate neurotransmission in the nucleus accumbens: A neurochemical study

Rahman

Bardo

2008

Brain Research

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“…The stimulation of the NMDA glutamate receptor is required in the reverse tolerance (or sensitization) to psychostimulants that results in manic-like behaviors in animals and humans, particularly for amphetamine [54][55][56][57][58][59] , methylphenidate [60] , cocaine [61][62][63][64] , apomorphine [65,66] and other dopamine mimetics [67,68] , nicotine [69] , morphine [70,71] and ethanol [72][73][74] , and some kind of stress [58,75] . Incidentally, it is worthy to recall that the sensitization (also called reverse tolerance) to psychostimulants (amphetamine-cocaine) result in manic-like behaviors in animals and in manic-like syndromes in humans (indeed, the so called "amphetamine psychosis" considered for a long time as "paranoid schizophrenia", can be considered, according with the more recent nosography, a manic episode with psychotic symptoms).…”

Section: The Role Of Nmda Glutamate Receptors In the Sensitization Phmentioning

confidence: 99%

Memantine: New prospective in bipolar disorder treatment

Serra

Demontis

Serra

et al. 2014

WJP

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“…These include changes in gene expression, which indicate involvement of similar pathways for addiction [20]. Altered expression involve gene products such as the CART, BDNF, and alpha-synuclein molecules [16,[21][22][23] and involve, in addition to the dopamine system, the GABA and glutamate neurotransmitter systems [3,7,24].…”

Section: Introductionmentioning

confidence: 99%

Expression of Transcripts for Myelin Related Genes in Postmortem Brain from Cocaine Abusers

2008

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Chronic abuse of cocaine is known to cause neuroadaptive changes in the nucleus accumbens (NAc) and ventral tegmental area (VTA). In addition, altered expression of the myelin-related genes MBP, MOBP, PLP1 as well as of MAL2 in NAc was recently reported by gene array analysis in brains from cocaine abusers. In the present study we used in situ hybridization to quantify transcript expression of these four genes, as well as for the myelin-related transcripts encoding quaking, EDG2, claudin-11, transferrin, CNP, and MAG in caudate, putamen, internal capsule, and NAc in postmortem brain from cocaine abusers and matched comparison subjects. Most transcripts were not different between these groups in these striatal regions, and contrary to previous reports, we did not detect any changes in the NAc. However, expression of the transcript encoding PLP1 was significantly decreased in ventral and dorsal regions of the caudate, putamen, and in the internal capsule. Additionally, expression of claudin-11 and transferrin was decreased in the caudate and internal capsule, respectively. PLP1 is expressed at very high levels in oligodendrocytes and is essential in maintaining stability of myelin sheets. Based on these findings, altered expression of PLP1 in most areas of the striatum suggests that widespread changes to the myelin structure could be associated with the adaptive changes following chronic cocaine abuse.

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Glutamatergic involvement in psychomotor stimulant action

Cited by 30 publications

References 188 publications

Environmental enrichment increases amphetamine-induced glutamate neurotransmission in the nucleus accumbens: A neurochemical study

Environmental enrichment increases amphetamine-induced glutamate neurotransmission in the nucleus accumbens: A neurochemical study

Memantine: New prospective in bipolar disorder treatment

Expression of Transcripts for Myelin Related Genes in Postmortem Brain from Cocaine Abusers

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