Glutamic acid decarboxylase in cerebrospinal fluid in infancy and childhood part II. Glutamic acid decarboxylase activity in cerebrospinal fluid of children with neurological diseases

Tada, H

doi:10.1016/s0387-7604(83)80080-1

Brain and Development

1983

DOI: 10.1016/s0387-7604(83)80080-1

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Glutamic acid decarboxylase in cerebrospinal fluid in infancy and childhood part II. Glutamic acid decarboxylase activity in cerebrospinal fluid of children with neurological diseases

H Tada

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Cited by 2 publications

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Hermitte¹,

Martin-Moutôt

Boucraut³

et al. 2000

Journal of Clinical Immunology

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Some beta-cell-specific autoantigens also are present in the central nervous system. Furthermore, stiff man syndrome, an autoimmune neurological disease, is frequently associated with diabetes and shares with this one an anti-GAD and IA-2 humoral immunoreactivity. We wondered whether these autoantibodies could be found in other neurological diseases with a present or supposed autoimmune origin. So, anti-GAD65 (GAD65A) and anti-IA-2 (IA-2A) autoantibodies were assayed in various neurological diseases. There was a higher prevalence of such antibodies in Lambert-Eaton myasthenic syndrome (LEMS) (GAD65A, 35%; IA-2A, 21%; double positivity, 18%) compared to amyotrophic lateral sclerosis (18%, 12%, and 12%, respectively) and multiple sclerosis (10%, 3%, and 3%, respectively). In LEMS, the humoral reaction was more frequent and/or appeared earlier in the paraneoplastic forms. The detection of such autoantibodies in patients with small-cell lung carcinoma (SCLC) without LEMS suggests that these autoantigens, GAD65 and IA-2, could be produced by SCLC tissue.

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Hermitte¹,

Martin-Moutôt

Boucraut³

et al. 2000

Journal of Clinical Immunology

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My life as a pediatrician in Juntendo University from the times having plentiful children to the times having scarce children in Japan

Ohtsuka

1996

Juntendo Medical Journal

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Glutamic acid decarboxylase in cerebrospinal fluid in infancy and childhood part II. Glutamic acid decarboxylase activity in cerebrospinal fluid of children with neurological diseases

Cited by 2 publications

References 23 publications

Untitled

Untitled

My life as a pediatrician in Juntendo University from the times having plentiful children to the times having scarce children in Japan

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