Glutaminase expression is correlated with adverse clinicopathological features and patient outcome in endometrial cancer

Asaka, S.; Yen, T.T.; Shen, Yu-Shiuan; Hong, J.; Asaka, Ryoichi; Shih, I.M.; Wang, T.L.; Gaillard, Stéphanie

doi:10.1016/j.ygyno.2020.05.383

Cited by 2 publications

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“…Importantly, inhibition of glutamine transport resulted in a reduced cell growth 62 . Furthermore, the increased glutaminase expression, catalyzing the conversion of glutamine to glutamate, was reported 63 . The decreased glutamate levels observed by us in the endometrial tumors of all grades (Table S3 ) may be due to the increased utilization of this metabolite in endometrial cancer.…”

Section: Discussionmentioning

confidence: 99%

Grading of endometrial cancer using 1H HR-MAS NMR-based metabolomics

Skorupa

Poński

Ciszek

et al. 2021

Sci Rep

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The tissue metabolomic characteristics associated with endometrial cancer (EC) at different grades were studied using high resolution (400 MHz) magic angle spinning (HR-MAS) proton spectroscopy. The metabolic profiles were obtained from 64 patients (14 with grade 1 (G1), 33 with grade 2 (G2) and 17 with grade 3 (G3) tumors) and compared with the profile acquired from 10 patients with the benign disorders. OPLS-DA revealed increased valine, isoleucine, leucine, hypotaurine, serine, lysine, ethanolamine, choline and decreased creatine, creatinine, glutathione, ascorbate, glutamate, phosphoethanolamine and scyllo-inositol in all EC grades in reference to the non-transformed tissue. The increased levels of taurine was additionally detected in the G1 and G2 tumors in comparison to the control tissue, while the elevated glycine, N-acetyl compound and lactate—in the G1 and G3 tumors. The metabolic features typical for the G1 tumors are the increased dimethyl sulfone, phosphocholine, and decreased glycerophosphocholine and glutamine levels, while the decreased myo-inositol level is characteristic for the G2 and G3 tumors. The elevated 3-hydroxybutyrate, alanine and betaine levels were observed in the G3 tumors. The differences between the grade G1 and G3 malignances were mainly related to the perturbations of phosphoethanolamine and phosphocholine biosynthesis, inositol, betaine, serine and glycine metabolism. The statistical significance of the OPLS-DA modeling was also verified by an univariate analysis. HR-MAS NMR based metabolomics provides an useful insight into the metabolic reprogramming in endometrial cancer.

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Section: Discussionmentioning

confidence: 99%