Glutamine Antagonists

Bennett, L. Lee

doi:10.1007/978-3-642-65806-8_24

Cited by 5 publications

(1 citation statement)

References 142 publications

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“…DFMO, a specific ornithine-decarboxylase (ODC) inhibitor [29, 381, was added to T8 medium supplemented with L-glutamine (300 mg/ml); after 48 h of culture, the villi in the explants had differentiated to the same extent as was found in the absence of DFMO. In the other hand, DON, an inhibitor of L-glutamine transfer [4,351, was added to T8 alone, T8 supplemented with L-glutamine or glucosamine. The results show that DON produced degenerative alterations, particularly in the epithelium, in explants cultured with T8 or T8 with L-glutamine.…”

Section: Effect Of Inhibitorsmentioning

confidence: 99%

Permissive effect of glutamine on the differentiation of fetal mouse small intestine in organ culture

Beaulieu

Calvert

1985

Differentiation

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Section: Effect Of Inhibitorsmentioning

confidence: 99%

Permissive effect of glutamine on the differentiation of fetal mouse small intestine in organ culture

Beaulieu

Calvert

1985

Differentiation

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Biochemical approaches to the combination chemotherapy of colon cancer

Sartorelli

Shansky

Rosman

2006

Cancer

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The employment of biochemical concepts to select drugs for use in the treatment of colorectal cancer is advocated. It is stressed that new drug mixtures, even those employing agents inactive alone, with unique mechanisms of action may be fashioned through biochemical design. Following delineation of activity in animal model systems, these drug combinations then become candidates for use in man. It is emphasized that 6-thioguanine is a particularly attractive agent for consideration as a component of new combinations of drugs to be used in patients with cancer. The desirability of this agent derives from (a) the known, albeit weak, activity of 6-thioguanine against colorectal neoplasms of man, thereby providing some inherent activity to be joined by additional materials; (b) a knowledge of several major biochemical and pharmacologic determinants of tissue susceptibility to its cytotoxic action, possibly allowing the ultimate selection of patients with a high probability of response; and (c) the availability of four different agents or classes of agents which synergistically interact with 6-thioguanine to inhibit the growth of malignant cells by diverse biochemical mechanisms.

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Purine Antagonists

LePage¹

1977

Chemotherapy

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Glutamine Antagonists

Cited by 5 publications

References 142 publications

Permissive effect of glutamine on the differentiation of fetal mouse small intestine in organ culture

Permissive effect of glutamine on the differentiation of fetal mouse small intestine in organ culture

Biochemical approaches to the combination chemotherapy of colon cancer

Purine Antagonists

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