Glutamine depletion in patients with Crimean‐Congo hemorrhagic fever

Aydın, Hüseyin; Engin, Aynur; Keleş, Sami; Ertemur, Zeynep; Hekim, Suleyman Nezih

doi:10.1002/jmv.25872

Cited by 4 publications

(6 citation statements)

References 46 publications

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“…Thus, further research was conducted on whether protein catabolism increases in the muscles of COVID-19 patients. While alanine is used as a substrate for gluconeogenesis by the liver, both alanine and glutamine are converted to tricarboxylic acid intermediates by leukocytes (28,29).…”

Section: Discussionmentioning

confidence: 99%

“…In our study, the increase in serum alanine and glutamine levels in the patient group compared to the control group (p<0.0001) was significant (Table II). In studies, it is known that the immune system is activated in the acute and convalescent period in Crimean-Congo Hemorrhagic Fever patients (29). Although there is an increase in catabolic reactions in COVID-19 affected patients, the increase in serum glutamine and alanine levels suggested that there may be an increase in the use of glutamine and alanine during infection.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of amino acid profile in serum of patients with Covid-19 for providing a new treatment strategy

Öztürk

Bayraktar

Bayraktar³

et al. 2022

J Med Biochemistry

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Objective: Amino acids have an important role in metabolism and may affect COVID-19-related outcomes. Our study, the amino acid serum level of hospitalized COVID-19 patients was evaluated for determining new treatment strategy. Methods: The amino acid profile covering 43 amino acids in 68 subjects, comprising 30 (14 men and 16 women) controls and 38 (16 men and 22 women) COVID-19 patients, were examined. In addition, the amino acid profiles of the participants were screened by LC-MS/MS. Results: Compared with the control group, serum levels of 27 amino acids increased in the patient group. Alpha diaminopimelic acid, sarcosine, and hydroxyproline amino acids were considerably higher in the control group than in the patient group (p<0.0001). There was no notable difference among control group and the case group for 13 amino acids (p≥0.05). A significant positive correlation was seen among the control group and the patient samples in the mean amino acid values (r=0.937; p<0.0001). Conclusion: These results postulated a clear picture on the serum levels of amino acid in the COVID-19 patients. Serum amino acids measured in hospitalized COVID-19 patients can explain the patient's metabolic status during the disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of amino acid profile in serum of patients with Covid-19 for providing a new treatment strategy

Öztürk

Bayraktar

Bayraktar³

et al. 2022

J Med Biochemistry

View full text Add to dashboard Cite

show abstract

“…Plasma glutamine levels were highest in healthy subjects; When compared to the control group, a statistically significant decrease was observed in both the acute and covelling period patient groups (Table 2,3). Aydın et al suggested that the plasma level of glutamine decreased due to the increase in the use of glutamine in CCHF patients [8]. Increases in alanine and glutamate levels may be due to BCAA catabolism as mentioned above.…”

Section: Discussionmentioning

confidence: 97%

“…In a study conducted with CCHF patients, Aydın and colleagues. showed that plasma glutamine levels decreased in patients [8]. Due to the relationship between AA level and distribution, infectious diseases, and immune response, we investigated the levels of different AAs in the plasma of CCHF patients in the acute and convalescent period in this study.…”

Section: Introductionmentioning

confidence: 99%

Changes in Plasma Amino Acid Levels in Crimean-Congo Hemorrhagic Fever Patients

Ertemür,

Aydın,

Engin

2024

Eur J Ther

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Objective: Crimean Congo Hemorrhagic Fever (CCHF) has an important place in viral hemorrhagic fever. Plasma amino acid (AA) levels of patients who were diagnosed with CCHF in the acute and convalescent period of the disease were investigated in this study. Methods: 35 patients were included in the study specific polymerase chain reaction (PCR) and/or IgM antibody positivity for CCHF virus. AA levels were measured in the plasma derived from the blood samples of the patient and control groups, using liquid chromatography-mass spectrometry (LC-MS/MS) technique. Results: In our study, we observed that plasma aspartate, glutamate, histidine, leucine, phenylalanine, tyrosine levels increased statistically significantly (p<0.05), while some AA levels decreased (p<0.05) in acute stage patients compared to the control groups. In addition, while there was an increase in plasma glutamate levels of convalescent patients compared to the control groups (p<0.05), there was a significant decrease in other AA levels (p<0.05). Conclusion: Further studies to investigate the relationship between increased or decreased AAs in the plasma levels of these patients and the immune system are likely to contribute to a better understanding of the pathogenesis of the disease and to guide the approach to whether AA supplementation is necessary for treatment. Keywords: biochemical analysis, Crimean‐Congo hemorrhagic fever virus, metabolic analysis, research andanalysis methods

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“…The body's metabolic response to COVID-19 infections has been partially demonstrated in non-targeted metabolomics studies [ 13 ]. We had been examined the metabolic responses to Crimean-Congo hemorrhagic fever virus infections and presented our findings in our previous articles [ 14 ]. Similarly, we analyzed the metabolic response to COVID-19 infections in terms of amino acid metabolism and wanted to bring it to your attention.…”

Section: Introductionmentioning

confidence: 99%