Glutamine dipeptide and cortisol change the liver glucose metabolism and reduce the severity of insulin-induced hypoglycaemia in untreated T1DM Swiss mice

Bataglini, Camila; Rezende, Diego Gustavo Linhares de; Primo, Marcos Aguiar; Gomes, Célia Regina Godoy; Pedrosa, Maria Montserrat Diaz; Godoi, Vilma Aparecida Ferreira de

doi:10.1080/13813455.2016.1273364

Cited by 8 publications

(12 citation statements)

References 48 publications

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“…Control + glutamine dipeptide (GPD), 6. Diabetic + GPD 248 mg/kg glutamine / 400 mg/kg GPD 30 days Significant increase TC, HDL Significant decrease TG No significant change Fasting glucose, LDL Bataglini et al, Brazil, 2017 [ 21 ] Rats were divided into 8 groups: 1. Non diabetic animals, 2.…”

Section: Resultsmentioning

confidence: 99%

“…Eight weeks of administering 1gr/kg glutamine resulted in a significant reduction in LDL, TC, and TG levels, and a significant improvement in HDL levels [ 18 ]. Three other studies showed a reduction in TG levels after glutamine supplementation; however, no statistically meaningful change was observed on other lipid parameters, including LDL, TC, and HDL [ 21 , 23 , 24 ]. In addition, Tsai et al found no significant changes after glutamine supplementation on the lipid profile [ 19 ].…”

Section: Resultsmentioning

confidence: 99%

“…The results of this systematic review showed that glutamine supplementation has a potential effect on improving fasting plasma glucose [ 17 , 18 , 22 , 25 , 28 , 29 , 31 , 32 ], postprandial blood glucose [ 14 , 21 , 26 , 27 , 30 ], and significant increases in insulin production and incretin hormones such as GIP and GLP-1 [ 18 , 26 , 27 , 29 , 30 , 33 ]. However, results from insulin sensitivity were contradictory [ 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…Dyslipidemia is one of the major complications of diabetes mellitus; thus, reducing lipid profile parameters may play a protective role in cardiovascular disease. Results demonstrated significant reductions in TG levels after glutamine administration [ 18 , 21 , 24 ]. However, the findings on TC, LDL, and HDL were contradictory [ 18 , 19 , 23 , 24 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…Anthropometric data derived from the studies is inadequate, although glutamine prevented weight loss after diabetes induction in animals [ 17 , 21 ]. Although trunk fat, total fat, and total fat-free mass were all significantly decreased, no significant changes were observed in BMI or body weight in human studies[ 28 ].…”

Section: Discussionmentioning

confidence: 99%

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A comprehensive insight into the effect of glutamine supplementation on metabolic variables in diabetes mellitus: a systematic review

et al. 2020

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Diabetes mellitus is one of the most important threats to human health in the twenty-first century. The use of complementary and alternative medicine to prevent, control, and reduce the complications of diabetes mellitus is increasing at present. Glutamine amino acid is known as a functional food. The purpose of this systematic review is to determine the potential role of glutamine supplementation on metabolic variables in diabetes mellitus. For this review, PubMed, SCOPUS, Embase, ProQuest, and Google Scholar databases were searched from inception through April 2020. All clinical trial and animal studies assessing the effects of glutamine on diabetes mellitus were eligible for inclusion. 19 studies of 1482 articles met the inclusion criteria. Of the 19 studies, nine studies reported a significant increase in serum GLP-1 levels. Also, eight studies showed reducing in serum levels of fasting blood sugar, four studies reducing in postprandial blood sugar, and triglyceride after glutamine supplementation. Although glutamine resulted in a significant increase in insulin production in seven studies, the findings on Hb-A1c levels were inconclusive. In addition to, despite of the results was promising for the effects of glutamine on weight changes, oxidative stress, and inflammation, more precise clinical trials are needed to obtain more accurate results. In conclusion, glutamine supplementation could improve glycemic control and levels of incretins (such as GLP-1 and GIP) in diabetes mellitus. However, more studies are needed for future studies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

A comprehensive insight into the effect of glutamine supplementation on metabolic variables in diabetes mellitus: a systematic review

et al. 2020

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Effects of dietary supplementation with glutamine and glutamate on the recovery of bitches after ovariohysterectomy due to pyometra

et al. 2021

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Individual differences in glucocorticoid regulation: Does it relate to disease risk and resilience?

Caulfield

Cavigelli

2020

Frontiers in Neuroendocrinology

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Glucocorticoid (GC) signaling varies among individuals, and this variation may relate to individual differences in health outcomes. To determine if and which aspects of signaling (basal, circadian, integrative, or reactivity) are associated with specific health outcomes, we reviewed recent studies that relate GCs to health outcomes. We identified papers through PubMed and reviewed 100 original research articles related to mental health, cardiovascular health, cancer, diabetes, obesity, pulmonary health, sleep, and fitness. Many studies reported elevated GC secretion associated with worse health, but this was only particularly true for integrative GC measures. On the other hand, accentuated cortisol awakening response and a steeper circadian rhythm were both associated with positive health outcomes. Overall, relationships between GC secretion and health outcomes were relatively weak. This systematic review of relationships between GC metrics and health outcomes highlights the importance of careful consideration when selecting methods to measure GC regulation in health research.

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Glutamine dipeptide and cortisol change the liver glucose metabolism and reduce the severity of insulin-induced hypoglycaemia in untreated T1DM Swiss mice

Abstract: At least some benefits of GDP and cortisol during hypoglycaemia came from their hepatic actions, and their use in diabetic patients should be explored.

Cited by 8 publications

References 48 publications

A comprehensive insight into the effect of glutamine supplementation on metabolic variables in diabetes mellitus: a systematic review

A comprehensive insight into the effect of glutamine supplementation on metabolic variables in diabetes mellitus: a systematic review

Effects of dietary supplementation with glutamine and glutamate on the recovery of bitches after ovariohysterectomy due to pyometra

Individual differences in glucocorticoid regulation: Does it relate to disease risk and resilience?

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