Glutamine has antidepressive effects through increments of glutamate and glutamine levels and glutamatergic activity in the medial prefrontal cortex

Son, Hyeonwi; Baek, Ji Hyeong; Go, Bok Soon; Jung, Doo-hyuk; Sontakke, Sneha B.; Chung, Hanshik; Lee, Dong-Kun; Roh, Gu Seob; Kang, Sang Soo; Cho, Gyeong Jae; Choi, Wan Sung; Kim, Hyun Joon

doi:10.1016/j.neuropharm.2018.09.040

Cited by 63 publications

(102 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chronic stress trended toward reducing prefrontal activity in the PFC as measured by expression of Egr1, an immediate early gene. This observation supports the hypothesis of prefrontal hypoactivity under conditions of stress and emotional dysfunction (Musazzi et al, 2015;Son et al, 2018 Overall, the results from the present study support the hypothesis that overinhibition in the PFC is part of the pathogenesis of anxiety-like behavior in females.…”

Section: Discussionsupporting

confidence: 90%

“…This decrease in dendritic arborization and spine density of prefrontal pyramidal neurons is thought to be one of the mechanisms behind reduced activity and plasticity in the PFC following stress and in affective disorders. Chronic stress reduces activity in the PFC, impairing its function and contributing to emotional dysregulation (Negrón-Oyarzo et al, 2016;Son et al, 2018).…”

Section: Prefrontal E/i Balance In Emotional Disorders and Chronic Stmentioning

confidence: 99%

“…Chronic stress has biphasic effects on glutamatergic transmission. Acute stress increases activity in the PFC while chronic stress causes hypoactivity (Musazzi et al, 2015;Son et al, 2018). This "tipping point" from hyper-to hypoactivity may arise from inhibitory over-compensation for the initial increase in excitation.…”

Section: Kv3mentioning

confidence: 99%

“…As previously discussed (Chapter 1), the precise nature of E/I imbalances in stress and affective disorders is still being unraveled.Stress appears to have biphasic effects on the prefrontal glutamatergic system.Acutely, stress enhances excitatory transmission in the PFC. Chronically, stress impedes glutamatergic transmission and causes prefrontal hypoactivity, along with emotional dysfunction(Musazzi et al, 2015;Son et al, 2018) (Figure 2). There are numerous reports of GABAergic deficits in stress and emotional disorders(Lüscher et al, 2011;Ghosal et al, 2017;Fogaça and Duman, 2019) alongside contradictory evidence for increased prefrontal inhibition(McKlveen et al, 2016;Shepard et al, 2016).Chapter 2 supports the hypothesis that increased prefrontal inhibition decreases prefrontal activity and drives anxiety in female mice.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Prefrontal excitatory/inhibitory balance in stress and emotional disorders: Evidence for over-inhibition

Page

Coutellier

2019

Neuroscience & Biobehavioral Reviews

146

View full text Add to dashboard Cite

Chronic stress-related emotional disorders like anxiety and depression involve imbalances between the excitatory glutamatergic system and the inhibitory γaminobutyric acid (GABA) system in the prefrontal cortex (PFC). However, the precise nature and trajectory of excitatory/inhibitory (E/I) imbalances in these conditions is not clear, with the literature reporting glutamatergic and GABAergic findings that are at times contradictory and inconclusive. In this dissertation, I propose and discuss the hypothesis that chronic stress-induced anxiety involves hypoactivity of the PFC due to increased inhibition, mediated in part through increased activity of prefrontal parvalbumin (PV)-expressing inhibitory interneurons. Differing sensitivity of the prefrontal GABAergic system and PV neurons to chronic stress may also underlie sex differences in the prevalence of anxiety disorders, with women presenting with anxiety at higher rates than men. I first present evidence that chronic stress increases the activity of prefrontal PV neurons, and that increased activity of this cell population induces hypoactivity of the PFC. Furthermore, increasing prefrontal PV cell activity using DREADDs (designer receptors exclusively activated by designer drugs) induces anxietylike behaviors specifically in females (Chapter 2). However, acute inhibition of prefrontal PV cells using DREADDs is insufficient to rescue stress-induced anxiety-like behavior, though it does modulate activity and synaptic plasticity in the PFC in a sex

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Prefrontal E/i Balance In Emotional Disorders and Chronic Stmentioning

confidence: 99%

Section: Kv3mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Prefrontal excitatory/inhibitory balance in stress and emotional disorders: Evidence for over-inhibition

Page

Coutellier

2019

Neuroscience & Biobehavioral Reviews

146

View full text Add to dashboard Cite

show abstract

“…L-glutamate is one the most important excitatory neurotransmitter at Central nervous System (CNS) level, and it is involved not only in neurotransmission [1,2] but also in normal brain functioning as movement, cognitive processes, memory and plasticity [3]. So, it has become a very important compound not only in biomedical analysis but also for the implications in the field of food [4].…”

Section: Introductionmentioning

confidence: 99%

Propylene Glycol Stabilizes the Linear Response of Glutamate Biosensor: Potential Implications for In-Vivo Neurochemical Monitoring

et al. 2018

View full text Add to dashboard Cite

L-glutamate is one the most important excitatory neurotransmitter at the central nervous system level and it is implicated in several pathologies. So, it is very important to monitor its variations, in real time in animal models’ brain. The present study aimed to develop and characterize a new amperometric glutamate biosensor design that exploits the selectivity of Glutamate Oxidase (GluOx) for l-glutamate, and the capability of a small molecule as propylene glycol (PG), never used before, to influence and extend the stability and the activity of enzyme. Different designs were evaluated by modifying the main components in their concentrations to find the most suitable design. Moreover, enzyme concentrations from 100 U/ml up to 200 U/ml were verified and different PG concentrations (1%, 0.1% and 0.05%) were tested. The most suitable selected design was Ptc/PPD/PEI(1%)2/GlutOx5/PG(0.1%) and it was compared to the same already described design loading PEDGE, instead of PG, in terms of over-time performances. The PG has proved to be capable of determining an over-time stability of the glutamate biosensor in particular in terms of linear region slope (LRS) up to 21 days.

show abstract

Optogenetic Animal Models of Depression: From Mice to Men

et al. 2022

View full text Add to dashboard Cite

Glutamine has antidepressive effects through increments of glutamate and glutamine levels and glutamatergic activity in the medial prefrontal cortex

Cited by 63 publications

References 56 publications

Prefrontal excitatory/inhibitory balance in stress and emotional disorders: Evidence for over-inhibition

Prefrontal excitatory/inhibitory balance in stress and emotional disorders: Evidence for over-inhibition

Propylene Glycol Stabilizes the Linear Response of Glutamate Biosensor: Potential Implications for In-Vivo Neurochemical Monitoring

Optogenetic Animal Models of Depression: From Mice to Men

Contact Info

Product

Resources

About