Glutamine protects mice from acute graft-versus-host disease (aGVHD)

Song, Eun-Kee; Yim, Jun-Mo; Yim, Joo-Yun; Song, Min-Young; Rho, Hye-Won; Yim, Sung Kyun; Han, Young Jin; Jeon, So Yeon; Kim, Hee Sun; Yhim, Ho‐Young; Lee, Na-Ri; Kwak, Jae-Yong; Sohn, Myung‐Hee; Park, Ho Sung; Jang, Kyu Yun; Yim, Chang-Yeol

doi:10.1016/j.bbrc.2013.04.047

Cited by 19 publications

(16 citation statements)

References 29 publications

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“…The mice were treated with PBS (control), GH (5 mg/kg/d), GLN (1 g/kg/d), or GH (5 mg/kg/d) + GLN (1 g/kg/d). GLN was administered through intraperitoneal injection and GH via subcutaneous injection . The treatment was given once daily for 7 days, and mice were sacrificed 24 hours after the final treatment.…”

Section: Methodsmentioning

confidence: 99%

Distinct Effects of Growth Hormone and Glutamine on Activation of Intestinal Stem Cells

Chen

Tseng

Yao

et al. 2017

J Parenter Enteral Nutr

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Section: Methodsmentioning

confidence: 99%

Distinct Effects of Growth Hormone and Glutamine on Activation of Intestinal Stem Cells

Chen

Tseng

Yao

et al. 2017

J Parenter Enteral Nutr

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“…The explanation could be that glutamine is catabolized to generate α-ketoglutarate (α-KG), which in T cells decreases generation of FOXP3 + cells and supports energy production through the tricarboxylic acid (TCA) cycle - critical for Th1 cells commitment. Conversely, Song et al reported that glutamine administration in a mouse aGVHD model significantly increased the fraction of Treg cells and inhibited GVHD-induced inflammation and tissue injury in the intestine, liver, skin and spleen (67). …”

Section: Environment and Treg Cellsmentioning

confidence: 99%

Role of Metabolism in the Immunobiology of Regulatory T Cells

Galgani

Rosa

Cava

et al. 2016

The Journal of Immunology

100

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Intracellular metabolism is central to cell activity and function. CD4+CD25+ regulatory T cells (Tregs) that express the transcription factor FOXP3 play a pivotal role in the maintenance of immune tolerance to self. Recent studies showed that the metabolism and function of Tregs are influenced significantly by local environmental conditions and the availability of certain metabolites. It also was reported that defined metabolic programs associate with Treg differentiation, expression of FOXP3, and phenotype stabilization. This article reviews how metabolism modulates FOXP3 expression and Treg function, what environmental factors are involved, and how metabolic manipulation could alter Treg frequency and function in physiopathologic conditions.

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“…It plays an important role in the control of gut barrier in the production of nucleotides for the enterocytes, hepatocytes, macrophages, lymphocytes and lymphoid tissue associated with the intestine. Thus, glutamine operates mainly in intestinal homeostasis as an energetic substrate for the mucosa (Demirkan et al 2010, Song et al 2013.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of β-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C)

et al. 2017

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Recently, glutamine and β-glucan have been demonstrated to play an important role in modulation of the immune system and in promoting intestinal health benefits. The aim of this study was to investigate the effect of this intervention on inflammatory responses and intestinal health in mice orally pretreated with soluble Saccharomyces cerevisiae derived 1,3/1,6-β-glucan (80mg/kg) with or without glutamine (150mg/kg) and then challenged with cytarabine (Ara-C) (15mg/kg). Improvements in villi and crypts were not observed in the β-glucan group. The intestinal morphometry in the glutamine group showed the best results. β-glucan in combination with glutamine presented the highest values of IL-1β and IL-10 and lowest values for leukocytes and INF-γ. Based on these results, combined β-glucan and glutamine pretreatment reduced intestinal inflammation and improved the immune response after Ara-C challenge.

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Glutamine protects mice from acute graft-versus-host disease (aGVHD)

Cited by 19 publications

References 29 publications

Distinct Effects of Growth Hormone and Glutamine on Activation of Intestinal Stem Cells

Distinct Effects of Growth Hormone and Glutamine on Activation of Intestinal Stem Cells

Role of Metabolism in the Immunobiology of Regulatory T Cells

Protective effect of β-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C)

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