Glutaraldehyde cross-linked chitosan microspheres for controlled delivery of Zidovudine

Nayak, Usha Y.; Gopal, S.; Mutalik, Srinivas; Ranjith, Averinen Kumar; Reddy, M. Sreenivasa; Gupta, Purushotham; Udupa, N.

doi:10.1080/02652040802246325

Cited by 58 publications

(42 citation statements)

References 15 publications

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“…The concentration of cross-linking agent was varied from 0.2-0.8% v/v and was treated to erythrocytes loaded with optimized concentration. Glutaraldehyde was used as cross-linking agent, as it makes more chemically and thermostable cross-links with protein than other aldehyde crosslinkers [13].…”

Section: Effect Of Cross-linking Agent On Drug Releasementioning

confidence: 99%

Design and Invitro Characterization of Metformin Loaded Resealed Erythrocytes

Viswanad¹,

Aiswarya²,

Parvathy³

et al. 2017

Asian J Pharm Clin Res

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Objective: Metformin is an oral antidiabetic drug in the biguanide class. It is the first-line drug of choice for the treatment of type 2 diabetes. The objective of this study was to retard the release of metformin using carrier erythrocyte for getting a parenteral slow release depot formulation. Methods:The study retards the release of metformin by encapsulating in carrier erythrocyte. Endocytosis is the method used for the encapsulation of the drug metformin.Results: The optimized formulation shows 98.34% of drug release within 12 days. From the in vitro release data, zero order kinetic graph shows the best fit graph. % cell recovered was found to be 73-78% and it suggests that the loading technique was less destructive. Conclusion:The optimized formulation is a perfect carrier for the parenteral slow release depot of metformin.

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Section: Effect Of Cross-linking Agent On Drug Releasementioning

confidence: 99%

Design and Invitro Characterization of Metformin Loaded Resealed Erythrocytes

Viswanad¹,

Aiswarya²,

Parvathy³

et al. 2017

Asian J Pharm Clin Res

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“…Normalmente, essa interação é feita pela inserção de moléculas bifuncionais de baixa massa molar ou íons, que promovem a formação de ligações cruzadas entre as cadeias de macromoléculas [4] . Este tipo de modificação pode ser realizado com agentes físicos, como o cálcio [5] e tripolifosfato [6,7] e agentes químicos, tais como: epicloridrina (EP) [8][9][10] , glutaraldeído (GA) [11][12][13][14][15] , N,N-metilenobisacrilamida [16] , genipina (GP) [17,18] , dentre outros.…”

Section: Introductionunclassified

Efeito da modificação química na solubilidade e intumescimento de microesferas à base de goma do cajueiro carboximetilada e quitosana

et al. 2015

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ResumoEsferas de goma do cajueiro carboximetilada e quitosana foram produzidas via complexação polieletrolítica. As esferas foram modificadas quimicamente de modo a obter-se sistemas estáveis em meio ácido e que apresentassem uma resposta de intumescimento diferenciado frente à variação de pH. As esferas foram modificadas por reacetilação da quitosana e por reticulação com epicloridrina, glutaraldeído e genipina. As esferas reticuladas foram caracterizadas por meio de técnicas como: espectroscopia de absorção no infravermelho, análise termogravimétrica, microscopia eletrônica de varredura e quanto à solubilidade em pH 1,2 e ao intumescimento. As esferas de goma do cajueiro carboximetilada e quitosana reacetilada, e as esferas reticuladas com epicloridrina apresentaram baixa resistência à dissolução em pH 1,2. Entretanto, as esferas reticuladas com glutaraldeído e genipina apresentaram resistência à dissolução e baixo coeficiente de difusão. As esferas reticuladas com genipina apresentaram um grau de intumescimento maior do que as esferas reticuladas com glutaraldeído nas concentrações de 3% e 5% (massa/volume). As esferas reticuladas com genipina apresentaram intumescimento responsivo à variação de pH e estabilidade em pH 1,2, indicando que esses sistemas possuem potencial para uso em sistemas de liberação controlada de fármacos por via oral. PalavrasTchave: goma do cajueiro, carboximetilação, quitosana, reticulação. AbstractChitosan/carboxymethylated cashew gum beads were produced via polyelectrolytic complexation. The beads were chemically modified to achieve stable acidic medium and to provide a swelling response in different pH. The beads were modified by chitosan reacetylation and by crosslinking with epichlorohydrin, glutaraldehyde and genipin. The beads were characterized by techniques such as: infrared spectroscopy, thermogravimetry, scanning electron microscopy and regarding their solubility at pH 1.2 and swelling. The beads of carboxymethyl cashew gum and reacetylated chitosan and those crosslinked with epichlorohydrin had low resistances to dissolution at pH 1.2. However, the beads crosslinked with glutaraldehyde and genipin showed resistance to dissolution along with low diffusion coefficients. Moreover, beads crosslinked with genipin presented a higher degree of swelling than beads crosslinked with glutaraldehyde at concentrations of 3% and 5% (weight/volume). Beads crosslinked with genipin presented responsive behavior to pH variation and stability at pH 1.2, indicating that these systems have potential for use in controlled drug delivery systems for oral administration.

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“…The filtrate was analyzed using a UV-vis spectrophotometer (Shimadzu 1601, Japan) at 230 nm (18) in triplicate. The drug concentration was determined using a calibration curve, and drug incorporation efficiency was calculated using the following equation (12,19):…”

Section: Drug Incorporation Efficiencymentioning

confidence: 99%

Evaluation of Cefixime-Loaded Chitosan Microspheres: Analysis of Dissolution Data Using DDSolver

Murtaza¹,

Ahmad²,

Khan³

et al. 2012

Dissolution Technol.

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The objectives of this study were to fabricate cefixime-loaded chitosan microspheres with the ultimate goal of prolonging drug release and to analyze the influence of various process variables on the properties of microspheres such as mode of drug release. The cefixime-loaded chitosan microspheres were fabricated using a coacervation technique. Various process variables like volume of solvent for chitosan (glacial acetic acid), chitosan concentration, volume of phase separation agent (NaOH solution), and glutaraldehyde concentration were varied to fabricate nine different formulations. Dissolution data were evaluated using DDSolver, new software developed for the kinetic analysis of dissolution data. The microspheres were spherical, porous, and dark brown. They ranged in size from 253.13 ± 8.4 to 369.1 ± 13.7 µm, and the incorporation efficiency varied from 29.9 ± 32% to 49.3 ± 4.5%. The F5 formulation with a drug/polymer ratio of 1:3 (w/w) was the most suitable in terms of incorporation efficiency (49.3 ± 4.5%), flow characteristics (Hausner ratio = 1.4), and drug release properties. The drug release was sustained up to many hours. Fickian diffusion was the primary mode of drug release from all cefixime-loaded chitosan microsphere formulations. These results show that cefixime can be successfully microencapsulated into chitosan shells by coacervation, which is influenced significantly by formulation variables such as chitosan and glutaraldehyde concentration.

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Glutaraldehyde cross-linked chitosan microspheres for controlled delivery of Zidovudine

Cited by 58 publications

References 15 publications

Design and Invitro Characterization of Metformin Loaded Resealed Erythrocytes

Design and Invitro Characterization of Metformin Loaded Resealed Erythrocytes

Efeito da modificação química na solubilidade e intumescimento de microesferas à base de goma do cajueiro carboximetilada e quitosana

Evaluation of Cefixime-Loaded Chitosan Microspheres: Analysis of Dissolution Data Using DDSolver

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