2021
DOI: 10.1016/j.redox.2021.101975
|View full text |Cite
|
Sign up to set email alerts
|

Glutaredoxin: Discovery, redox defense and much more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

3
80
0
1

Year Published

2021
2021
2024
2024

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 88 publications
(84 citation statements)
references
References 216 publications
3
80
0
1
Order By: Relevance
“…These two redox systems work in parallel to synergistically maintain redox balance in cells [ 39 ]. The GSH-Grx system, consisting of GSH, GR, GPx, and Grx, specifically reduces protein-glutathione mixed disulfides [ 40 ]. In chicken, Grx is present in the cytosol and nucleus while Grx5 and GPx4 are in the mitochondrion [ 6 ].…”
Section: Discussionmentioning
confidence: 99%
“…These two redox systems work in parallel to synergistically maintain redox balance in cells [ 39 ]. The GSH-Grx system, consisting of GSH, GR, GPx, and Grx, specifically reduces protein-glutathione mixed disulfides [ 40 ]. In chicken, Grx is present in the cytosol and nucleus while Grx5 and GPx4 are in the mitochondrion [ 6 ].…”
Section: Discussionmentioning
confidence: 99%
“…84, 85 Notably, some genes involved in the modulation of the redox balance ( GLRX3 , SELENOF ) showed double regulation after treatment with B as well as others active in proteostasis ( PSMA5 after exposure to M , UBE2N to B ). 81, 86 Among the downregulated genes, some were associated to cell adhesion ( PLEKHO1 , ITGB3 , ICAM1 ) and translation ( RPL19 , RPL13 ). 87…”
Section: Resultsmentioning
confidence: 99%
“…84,85 Notably, some genes involved in the modulation of the redox balance (GLRX3, SELENOF) showed double regulation after treatment with B as well as others active in proteostasis (PSMA5 after exposure to M, UBE2N to B). 81,86 Among the downregulated genes, some were associated to cell adhesion (PLEKHO1, ITGB3, ICAM1) and translation (RPL19, RPL13). 87 Collectively, pairwise integration of RNA-seq and ATAC-seq shed light on genes with robust regulation at the transcriptional and chromatin level, adding further details to the previously identified response pathways.…”
Section: The Response To 3-ceps Is Further Regulated At the Chromatin...mentioning
confidence: 99%
“…GSH behaves as a "guardian" of redox status, as well as a mediator of redox signal transduction [110] and some reports point to GSH depletion as the main culprits of oxidative stress favoring senescence [93,111,112]. Oxidized glutathione (GSSG) is reduced back to GSH by the glutaredoxin (GRX) system [113] (Figure 2). GRX1 has been recently linked to cell senescence.…”
Section: Antioxidant Systems and Cell Senescencementioning
confidence: 99%