Glutathione as a photo-stabilizer of avobenzone: an evaluation under glass-filtered sunlight using UV-spectroscopy

Govindu, Panchada Ch V; Hosamani, Basavaprabhu; Moi, Smriti; Venkatachalam, Dhananjeyan; Asha, Sabreddy; John, Varun N.; Vuddanti, Sandeep; Gowd, Konkallu Hanumae

doi:10.1039/c8pp00343b

Cited by 14 publications

(16 citation statements)

References 41 publications

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“…[7][8][9][10][11][12][13][14] Previous studies have sought to identify ingredients that stabilise the more effective chelated enol form of avobenzone, such as compatible UV filters or antioxidants. [15][16][17] Micellar and lipid microparticle encapsulation of avobenzone have also been shown to have a role in enhancing its photostability. 9,18 Deuteration of the diketo methylene/enol moiety affects the tautomerisation equilibrium, by shifting it towards the ketone form.…”

Section: Introductionmentioning

confidence: 99%

Determining the photostability of avobenzone in sunscreen formulation models using ultrafast spectroscopy

Holt

Rodrigues

Cebrián³

et al. 2021

Phys. Chem. Chem. Phys.

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Section: Introductionmentioning

confidence: 99%

Determining the photostability of avobenzone in sunscreen formulation models using ultrafast spectroscopy

Holt

Rodrigues

Cebrián³

et al. 2021

Phys. Chem. Chem. Phys.

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“…To overcome the photo-instability of avobenzone, various photostabilizers have been used as additives, including antioxidants such as vitamin C, vitamin E, and ubiquinone. The dual role of glutathione as a skin whitening agent and a photostabilizer of avobenzone may be useful for the development of multipurpose cosmetic lotions [49]. Avobenzone is dibenzoyl methane derivative.…”

Section: Avobenzonementioning

confidence: 99%

Sunscreen and Suntan Preparations

2019

ARC Journal of Pharmaceutical Sciences

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BACKGROUND Ra (Re) was the primary name of the sun god of Ancient Egypt. According to Osiris myth, Nut, the mother of Osiris swallowed the setting sun (Ra) each evening and gave birth to him each morning. The Ancient Egyptians were well aware of the dangers of the sun. Their lands were scorched with heat. Women protected their skin, preferring light skin to dark in their cultural hierarchy of beauty. Recent discoveries written on papyri and the walls of several tombs unearthed ingredients and formulations in use in Ancient Egypt specifically addressing issues of sun damage to the hair and skin. Also, a brief historical review manifests the following interesting things indeed: ▪ Jasmin was used to heal the sun-damaged skin. Recent evidence reveals that Jasmin aids in DNA repair at the cellular level. ▪ Aloe was used to heal sun-damaged skin. ▪ Olive oil was used as a hydrating oil for both skin and hair damaged by overexposure to the sunlight. ▪ Almond oil was applied before and after sun exposure to hydrate the sun-damaged skin, improving elasticity and texture. ▪ Rice bran extracts were used in sunscreen preparations. Today, gamma oryzanol extracted from rice bran has UV absorbing properties. ▪ kohl (to darken eyes in order to combat sunlight impairment to the retina in the glare of the desert sun), red ochre (to redden and impart a rosy glow in women's makeup mimicking the effect of the sun on the skin), and henna oil (to dye the lips and nails, darken the color of the hair and skin, and protect light skin from the sun). Today, henna is one of the most widely used natural sunscreen with both UVA and UVB protection.

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“…To overcome the photoinstability of avobenzone, various photostabilizers have been used as additives, including antioxidants such as vitamin C, vitamin E, and ubiquinone. The dual role of glutathione as a skin whitening agent and a photostabilizer of avobenzone may be useful for the development of multipurpose cosmetic lotions [49]. Avobenzone is dibenzoyl methane derivative.…”

Section: Classification Of Sunscreensmentioning

confidence: 99%

An Extensive Review of Sunscreen and Suntan Preparations

Mohiuddin¹

2019

Preprint

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The sunscreen industry is achieving remarkable worldwide prominence by responding to the growing need for skin protection with fast-paced innovation. Increased consumer awareness of the harmful effects of sunlight has fueled the demand for improved photo protection. The need for broad-spectrum protection from both UVA and UVB rays has inspired scientists worldwide to research new cosmetic formulations and delivery systems. More effective sunscreen actives, emollients and novel cosmetic and functional ingredients have been regularly added to the formulator’s repertoire. Creativity in innovation has been hindered only by regulatory agencies and patent restrictions worldwide. Familiarity with the current restrictive regulations and patent law infringements has become integral to any research effort attempting to provide improved protection to individuals affected by the sun’s damaging effects. The increasing incidence of skin cancers and photo damaging effects caused by ultraviolet radiation has increased the use of sun screening agents, which have shown beneficial effects in reducing the symptoms and reoccurrence of these problems. Unlike the situation in Europe where sunscreen ingredients are considered under cosmetics guidelines, the FDA is required to define sunscreens as drugs since they are advertised to prevent sunburn and, more recently, the risk of skin cancer. In the USA, the FDA has been regulating this industry since August 25, 1978, with the publication of the Advance Notice of Proposed Rulemaking. Sunscreens are considered drugs and cosmetics and therefore must be governed by the FDA-OTC monograph. With the variety of sunscreen agents used in cosmetic and UV protection products, Australia, Canada, and the European Union (EU) have also developed regulatory protocols on safe sunscreen product use. Unlike the USA though, Australia has approved 34 active sunscreen ingredients and the EU has approved 28 of these ingredients. Current FDA regulations allow labeling of sunscreen products to a maximum of 30þ, despite the many products currently available with numbers as high as 100. From a cosmetic formulation point of view, increasing the SPF number in a product is governed by simple chemical principles.

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Glutathione as a photo-stabilizer of avobenzone: an evaluation under glass-filtered sunlight using UV-spectroscopy

Abstract: Glutathione significantly attenuates the photodegradation of avobenzone under glass-filtered sunlight.

Cited by 14 publications

References 41 publications

Determining the photostability of avobenzone in sunscreen formulation models using ultrafast spectroscopy

Determining the photostability of avobenzone in sunscreen formulation models using ultrafast spectroscopy

Sunscreen and Suntan Preparations

An Extensive Review of Sunscreen and Suntan Preparations

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