Glutathione conjugation attenuates biological activities of 6-dehydroshogaol from ginger

Zhang, Guodong; Nitteranon, Viriya; Chan, Lok Yan; Parkin, Kirk L.

doi:10.1016/j.foodchem.2013.02.073

Cited by 31 publications

(23 citation statements)

References 29 publications

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“…Activation of phase II detoxification enzymes (GST, GR and GSH) and inhibition of phase I enzymes were noticed in orally administered [6]‐shogaol. Similarly, previous studies reported that ginger‐derived structural analogue such as [6]‐gingerol, [6]‐dehydroshogaol possibly induce phase II detoxification enzymes in different experimental models (Li et al ., ; Zhang et al ., ).…”

Section: Discussionmentioning

confidence: 97%

“…Previous study clearly shown that natural occurring phytochemical can able to enhance phase II drug detoxification enzymes and elevate antioxidant thereby, inhibit carcinogenesis (Kavitha et al, 2013). Overproduction of toxins may neutralize phase II enzymes through the conjugation process, resulting in decreased oxidative (Li et al, 2011;Zhang et al, 2013). Alteration of oncogenes and tumour suppressor genes expression is associated with apoptosis and/or tumour development (Wong, 2011).…”

Section: Discussionmentioning

confidence: 99%

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[6]‐Shogaol, a Novel Chemopreventor in 7,12‐Dimethylbenz[a]anthracene‐induced Hamster Buccal Pouch Carcinogenesis

Suresh

Annamalai

2016

Phytotherapy Research

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Oral cancer is a major cause of morbidity and mortality in developing countries. Despite advances in chemotherapy for the cancer management, the survival rate has not yet been improved. Dietary nutrient has been receiving a lot of attention and interest in the chemotherapeutic development. [6]-Shogaol is a major bioactive compound identified in ginger that possesses many pharmacological properties. The aim of the present study is to investigate the effect of [6]-shogaol on 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch (HBP) carcinogenesis. Oral squamous cell carcinoma induced in HBP by painting with 0.5% 7,12-dimethylbenz(a)anthracene (DMBA), thrice in a week for 16 weeks. We observed 100% tumour incidence, decreased levels of lipid peroxidation, antioxidant, and phase II detoxification enzymes (GST, GR and GSH) in DMBA-induced hamsters. Further, enhanced activity of phase I enzymes (cytochrome p450 and b5) and over-expression of mutant p53, Bcl-2 and decreased expression of wild type p53 and Bax were noticed in DMBA-induced hamsters. Our results indicated that [6]-shogaol (10, 20 and 40 mg/kg body weight) treated with DMBA-painted hamsters, considerably reversed tumour incidence, improved antioxidant status, phase II detoxification enzymes, and also inhibit lipid peroxidation and phase I enzymes. Moreover, [6]-shogaol inhibits mutant p53 and Bcl-2 expression and significantly restored normal p53, Bax levels. Thus, we concluded that [6]-shogaol prevents DMBA-induced HBP carcinogenesis through its antioxidant as well as modulating apoptotic signals.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

[6]‐Shogaol, a Novel Chemopreventor in 7,12‐Dimethylbenz[a]anthracene‐induced Hamster Buccal Pouch Carcinogenesis

Suresh

Annamalai

2016

Phytotherapy Research

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“…The reactivity of each of these classes has important implications for potential toxic side effects: hERG channel inhibition is related to cardiotoxicity; 99−101 cytochrome P450 (CYP450) and glutathione S -transferase (GST) inhibition can lead to impaired detoxification and potential toxic drug–drug contraindications. 102 Beyond specific enzyme toxicity, compound 1 has recently been shown to be an active iron chelator in vivo, inducing a state of overt iron deficiency in mice fed diets poor in iron. 44 This suggests that 1 has the potential to affect systemic iron metabolism, particularly in people with a preexisting suboptimal iron status.…”

Section: Admet (Absorption Distribution Metabolism Excretion and mentioning

confidence: 99%

The Essential Medicinal Chemistry of Curcumin

et al. 2017

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Curcumin is a constituent (up to ∼5%) of the traditional medicine known as turmeric. Interest in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led to their extensive investigation. Curcumin has recently been classified as both a PAINS (pan-assay interference compounds) and an IMPS (invalid metabolic panaceas) candidate. The likely false activity of curcumin in vitro and in vivo has resulted in >120 clinical trials of curcuminoids against several diseases. No double-blinded, placebo controlled clinical trial of curcumin has been successful. This manuscript reviews the essential medicinal chemistry of curcumin and provides evidence that curcumin is an unstable, reactive, nonbioavailable compound and, therefore, a highly improbable lead. On the basis of this in-depth evaluation, potential new directions for research on curcuminoids are discussed.

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“…Hal ini menunjukkan bahwa 6-shogaol memiliki antiinflamasi yang paling poten dibandingkan semua jenis gingerol, dan 10-gingerol lebih poten dibanding gingerol lain, dan 6-gingerol merupakan bahan yang paling lemah jika dibandingkan dengan gingerol lain. Tetapi hasil lain ditemukan bahwa 6 dehydroshogaol lebih poten dibandingkan 6-shogaol dalam mengurangi pembentukan mediator proinflamasi seperti Nitrit Oksida dan PGE-2 pada sel makrofag tikus (Zhang et al, 2013). Penelitian Ho, Chang, dan Lin pada tahun 2013 juga ditemukan bahwa 6shogaol, 10-gingerol dan 10-shogaol menghambat peradangan saraf pada model kultur mikroglia BV2 yang diaktifkan lipopolisakarida, dimana digunakan gingerol bersama dengan shogaol pada konsentrasi 20 µM dapat menghambat produksi nitrit oksida sebesar 99,3%.…”

Section: Pendahuluanunclassified

Ginger as Anti-Inflammatory

Artasya

Parapasan

2019

jppp

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Inflamasi merupakan respon tubuh dalam mengatasi kerusakan jaringan dimana akan dilepaskannya mediator-mediator proinflamasi. Penyebab inflamasi dapat berupa mikroorganisme seperti bakteri, virus, jamur, parasit, adanya protein asing, dan kerusakan jaringan. Jahe merupakan tanaman yang sejak lama dikenal sebagai tanaman rempah yang memiliki kandungan utama gingerol dan shogaol yang berpotensi sebagai antiinflamasi. Literatur review ini dibuat menggunakan penelitian terbaru yang didapat dari buku, dan jurnal internasional terkait dengan kata kunci jahe, Zingiber officinale, dan antiinflamasi. Tahun penerbitan literatur yang dipakai adalah tahun 2010 sampai tahun 2019 dengan jumlah literatur yang ditemukan 30 literatur, dimana 24 literatur dipakai sebagai referensi dan dianalisis menggunakan metode systemic literature review. Berbagai penelitian menyebutkan bahwa jahe memiliki efek antiinflamasi bagi tubuh. Kandungan gingerol dan shogaol pada jahe dapat menekan produksi nitrit oksida dan prostaglandin. Selain itu etil asetat dan nanopartikel yang ada pada jahe juga dapat menurunkan sitokin pro-inflamasi pada tubuh.

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Glutathione conjugation attenuates biological activities of 6-dehydroshogaol from ginger

Cited by 31 publications

References 29 publications

[6]‐Shogaol, a Novel Chemopreventor in 7,12‐Dimethylbenz[a]anthracene‐induced Hamster Buccal Pouch Carcinogenesis

[6]‐Shogaol, a Novel Chemopreventor in 7,12‐Dimethylbenz[a]anthracene‐induced Hamster Buccal Pouch Carcinogenesis

The Essential Medicinal Chemistry of Curcumin

Ginger as Anti-Inflammatory

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