1992
DOI: 10.1016/0304-3835(92)90047-y
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Glutathione conjugation of microsome-mediated and synthetic aflatoxin B1-8,9-oxide by purified glutathione S-transferases from rats

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Cited by 37 publications
(17 citation statements)
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“…The mechanism of most of the chemopreventive activity of antioxidants against carcinogens is that they activate the detoxification system such as GST [39]. GSH related enzymes play an important role in the protection of mammalian cells against the harmful effects of chemical carcinogens and other alkylating agents [40]. In the presence of xenobiotics and GSH as a substrate GST and GPx are generally induced as detoxifying enzymes, conjugation of toxic electrophiles with GSH take place, conferring a selective growth advantage to cancer cells.…”
Section: Discussionmentioning
confidence: 99%
“…The mechanism of most of the chemopreventive activity of antioxidants against carcinogens is that they activate the detoxification system such as GST [39]. GSH related enzymes play an important role in the protection of mammalian cells against the harmful effects of chemical carcinogens and other alkylating agents [40]. In the presence of xenobiotics and GSH as a substrate GST and GPx are generally induced as detoxifying enzymes, conjugation of toxic electrophiles with GSH take place, conferring a selective growth advantage to cancer cells.…”
Section: Discussionmentioning
confidence: 99%
“…Trachootham et al (2009) have suggested that if the levels of ROS are altered by GSH modulation, it is the way to kill cancer cells without causing significant toxicity to normal cells. In addition, GSHrelated enzymes play a role in offering protection to the cells against the deleterious effects of chemical carcinogens and other alkylating agents (Gopalan et al, 1992). When intracellular GSH levels are depleted, the cells are more vulnerable to the attacks by ROS.…”
Section: Control+zingerone Dmhmentioning
confidence: 99%
“…Concomitant analysis of AFB1-GSH conjugate in bile as shown earlier , could have provided direct evidence for the involvement of GSTs in modulation of AFB1-DNA binding in vivo studies. Similarly, analysis of hepatic cytosolic inhibition of microsome-mediated AFB1-DNA binding to exogenous DNA with the formation of AFB1-GSH conjugate (Raj et al, 1984) or direct assay of AFB1-GSH conjugate with hepatic cytosols and synthetic AFB1-epoxide as a substrate as reported previously (Gopalan et al, 1992;Chen et al, 1995) may have implicated GSTs in modulation of AFB1-DNA binding.…”
Section: ꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏmentioning
confidence: 71%