Glutathione depletion-mediatedin situtransformation of Prussian blue nanocubes for enhanced tumor-specific imaging and photoimmunotherapy

Abstract

Tumor imaging and photoimmunotherapy holds great promise for precise and efficient tumor treatment. However, tumor microenvironment (TME) with high redox level inhibits reactive oxygen species mediated-treatment and immune response. The...

Magnetic and injectable Fe-doped liquid metals for controlled movement and photothermal/electromagnetic therapy

“…Due to the optical absorption in the near-infrared (NIR) region, LM can transform energy into heat under NIR laser irradiation, 31,32 which is conducive to improving the efficacy and precision of tumor diagnosis and treatment. 33–35 To evaluate the photothermal effect of 5%Fe/LM, it was exposed to an NIR laser (808 nm, 1.0 W cm −2 ). As shown in Fig.…”

Recent advances of nanocrystals in cancer theranostics

“…In vivo investigations confirm the synergistic anticancer activity by ferroptosis and chemotherapy with minimum side effects by MRI scanning. 139 By depleting glutathione (GSH), S. Tang et al 140 produced NCs of Prussian blue from the berlin green precursor. Both tumor cells and dendritic cells undergo this change.…”

“…With no negative impact on healthy cells, these NCs promote tumor-specific 3D photoacoustic imaging and phototherapy of the tumor zone. 140 The maturation of dendritic cells and immunogenic cell death can be produced by increased phototherapy with the depletion of NCs. Thus, they maintained cancer-specific photoacoustic imaging and efficient photoimmunotherapy.…”

“…Thus, they maintained cancer-specific photoacoustic imaging and efficient photoimmunotherapy. 140 Similarly, M. Chang et al explained dual-modal imaging platforms through photothermal and photoacoustic imaging for cancer detection and treatment. 141 Here, Au is employed to trap light on the NCs of neodymium vanadate (NdVO 4 ).…”