Glutathione elicits enhanced biosynthesis of bonducellin, a homoisoflavonoid, in Caesalpinia bonducella leaf callus

Karthikeyan, Manivannan; Baskar, Baburaj; Kandasamy, Veerapandiyan; Balasundaram, Usha

doi:10.1007/s11240-023-02551-1

Cited by 2 publications

(1 citation statement)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[7] Bioactive homo iso-flavonoids like bonducellin, which have been demonstrated to have a number of positive properties, including antibacterial, antioxidant, anticancer, anti-estrogenic, anti-inflammatory, and anti-androgenic activities, are abundant in the seeds and kernels of this plant, according to . [10][11][12] Nithiyanandam et al (2023) suggested that the aqueous solution has better in-vitro antioxidant properties than alternate solvents. Furthermore, the extract derived from this solution demonstrated a noteworthy enhancement in antioxidant activity, coupled with a reduction in lipid peroxidation.…”

Section: Abstract a R T I C L E I N F Omentioning

confidence: 99%

Evaluating The Analgesic Activity of Leaf, Stem Bark Extract And Isolated Nutraceuticals of <i>Caesalpinia Bonducella L (Roxb.)</i>

B. J.,

M. B.,

et al. 2024

Int. J. Pharm. Sci. Drug Res.

View full text Add to dashboard Cite

The objective of this study was to evaluate the analgesic potential of Caesalpinia bonducella L (Roxb.) by evaluating the efficacy of leaf and stem bark extracts and isolated nutraceuticals. Nutraceuticals were isolated via column chromatography and characterized using IR and NMR. Analgesic activities were assessed in vivo using the hot plate, capsaicin-induced pain, and tail flick tests on 36 albino mice across nine groups. Phytochemical screening revealed flavonoids and polyphenols. Pure nutraceuticals displayed superior analgesic properties compared to the control. Ethanol extracts of Caesalpinia bonducella leaf and bark exhibited higher analgesic efficacy than other extracts and the control (P<0.05). The study suggests the plant's potential in the nutraceutical field, highlighting its therapeutic value and positioning it as a valuable resource for India's nutraceutical sector.

show abstract

Section: Abstract a R T I C L E I N F Omentioning

confidence: 99%

Evaluating The Analgesic Activity of Leaf, Stem Bark Extract And Isolated Nutraceuticals of <i>Caesalpinia Bonducella L (Roxb.)</i>

B. J.,

M. B.,

et al. 2024

Int. J. Pharm. Sci. Drug Res.

View full text Add to dashboard Cite

show abstract

De novo assembly and annotation of Caesalpinia bonducella L. seed transcriptome identifies key genes in the biosynthesis of bonducellin, a homoisoflavonoid

Veerapandiyan,

Ravichandiran,

N. Patra

et al. 2024

Natural Product Research

Self Cite

View full text Add to dashboard Cite

Caesalpinia bonducella L. is a traditional medicinal plant containing a potential homoisoflavonoid, bonducellin, with therapeutic values against polycystic ovary syndrome, oxidative damage, pathogenic bacteria, irregular menstrual cycle, ovarian cancer and diabetes.Owing to the multi-therapeutic properties of bonducellin, knowledge of its biosynthetic pathway genes will help understand its regulatory mechanism and thus improve the yield. This study sequenced C. bonducella seed mRNA transcriptome to identify the genes in bonducellin biosynthesis. Before this, the presence of bonducellin in the seed samples was analysed by HPLC using the chemically synthesized bonducellin as the standard. Seven key genes encoding enzymes involved in the synthesis of bonducellin via the phenylpropanoid pathway were identified. The expression of selective genes from the bonducellin biosynthetic pathway was S2 validated using qRT-PCR and comparable with RNA-Seq data. Here, we put forth the sequences of 67,560 genes from C. bonducella and highlight the bonducellin biosynthetic pathway genes.

show abstract

Glutathione elicits enhanced biosynthesis of bonducellin, a homoisoflavonoid, in Caesalpinia bonducella leaf callus

Cited by 2 publications

References 29 publications

Evaluating The Analgesic Activity of Leaf, Stem Bark Extract And Isolated Nutraceuticals of <i>Caesalpinia Bonducella L (Roxb.)</i>

Evaluating The Analgesic Activity of Leaf, Stem Bark Extract And Isolated Nutraceuticals of <i>Caesalpinia Bonducella L (Roxb.)</i>

De novo assembly and annotation of Caesalpinia bonducella L. seed transcriptome identifies key genes in the biosynthesis of bonducellin, a homoisoflavonoid

Contact Info

Product

Resources

About