Glutathione S-Transferase P Influences Redox Homeostasis and Response to Drugs that Induce the Unfolded Protein Response in Zebrafish

Abstract

ANOVA, analysis of variance; atf, activating transcription factor 4; atf6, activating transcription factor 6; baxb, Bcl2 associated x b; bida, BH3-interacting domain death agonist a; bim, Bcl2 interacting mediator of cell death; bip: binding immunoglobulin protein; BMDDCs, bone marrow-derived dendritic cells; CDNB, 1-Chloro-2,4-dinitrobenzene; dnajc3, DnaJ homolog subfamily C member 3; ddit3 (chop), DNA damage-inducible transcript 3; DLAR, Division of laboratory animal resources; dpf, day post fertilization; edem1, ER degradation-enhancing alpha-mannosidase-like 1; ER, This article has not been copyedited and formatted. The final version may differ from this version.

Downregulation of VPS13C promotes cisplatin resistance in cervical cancer by upregulating GSTP1

“… 32 , 33 , 34 On the other hand, the phase II detoxifying enzyme GSTP1 is reported to play an important role in maintaining homeostasis of ER and mitochondria protection against oxidative stress. 35 , 36 , 37 In the present study, when VPS13C was knocked down, GSTP1 increased at the mRNA and protein levels. We speculate that increased expression of GSTP1 may be a response to the perturbation of homeostasis in LE/Lys, ER, or mitochondria, which is induced by VPS13C depletion.…”