Glutathione <i>S</i>-Transferase Polymorphisms and the Synergy of Alcohol and Tobacco in Oral, Pharyngeal, and Laryngeal Carcinoma

Peters, Edward S.; McClean, Michael D.; Marsit, Carmen J.; Luckett, Brian; Kelsey, Karl T.

doi:10.1158/1055-9965.epi-06-0503

Cited by 73 publications

(61 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As expected, the mean age and distribution of gender were similar between cases and controls. As previously described (20,21), there was an increasing relative risk of HNSCC with increasing pack-years smoked, with individuals in the highest quartile having an OR of 3.7 [95% confidence interval (95% CI), 2.7-5.1]. The estimated magnitude of cancer risk for tobacco use was similar for oral and pharyngeal cancers but was greatly elevated (OR, 12.6; 95% CI, 6.2-25.5) for laryngeal cancer.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

A Genotype-Phenotype Examination of Cyclin D1 on Risk and Outcome of Squamous Cell Carcinoma of the Head and Neck

Marsit

Black²,

Posner³

et al. 2008

Clinical Cancer Research

Self Cite

View full text Add to dashboard Cite

Purpose: The variant allele of CCND1 G870A encodes a splice variant of the cyclin D1 protein, which possesses an increased half-life. To confirm the phenotypic effect of the variant allele, we examined the immunohistochemical staining pattern of the protein in tumors from a case population of head and neck squamous cell carcinoma (HNSCC) and compared it with the genotype of these individuals. We also examined how this genotype was associated with the risk of HNSCC and if this genotype-phenotype association was related to patient outcome. Experimental Design: In a population-based case-control study of 698 cases and 777 controls, we both genotyped all participants for the CCND1 gene and did immunohistochemical staining of the cyclin D1protein in the HNSCC tumors. Results: The variant AA genotype was significantly associated with positive immunohistochemical staining (P < 0.02), and this variant genotype was associated with a significantly elevated odds ratio of 1.5 (95% confidence interval, 1.1-2.0) for HNSCC overall, with risk greatest in oral and laryngeal sites. Positive immunohistochemical staining was inversely related to human papillomavirus 16 DNA present in the tumor (P < 0.03). The AA genotype and superpositive immunohistochemical staining for cyclin D1 also had independent and significant effects on patient survival. Conclusions:These results strongly suggest that this splice variant, when present in two copies, is a significant predictor of both the occurrence of HNSCC as well as patient survival after treatment. These data further indicate that this variant protein is an important determinant of individual response to therapy for this disease.

show abstract

Section: Resultsmentioning

confidence: 99%

“…The study population has been previously described (20,21). Briefly, incident cases of HNSCC were identified from nine medical facilities in the Boston metropolitan area, with histologic classification of malignancy reported by pathology of the participating hospitals and confirmed by independent study pathologist.…”

Section: Methodsmentioning

confidence: 99%

A Genotype-Phenotype Examination of Cyclin D1 on Risk and Outcome of Squamous Cell Carcinoma of the Head and Neck

Marsit

Black²,

Posner³

et al. 2008

Clinical Cancer Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…Sixteen (28%) (30,35,55,58,62,64,(66)(67)(68)71,72,74,79,(84)(85)(86) of the studies showed a significantly higher risk for HNC in subjects with the null Twenty-three (55%) ORs from 42 studies of the null GSTT1 genotype vs. the positive genotype were >1, and 7 studies (56,64,72,83,85,95,96) showed a significantly higher risk for HNC in subjects with the null genotype than in those with the positive genotype, suggesting that the null GSTT1 genotype may be associated with increased risk for HNC. In contrast, only 1 study showed a significantly lower risk with the null GSTT1 genotype than the positive genotype.…”

Section: Carcinogen Metabolic Genesmentioning

confidence: 99%

“…Sixteen (28%) (30,35,55,58,62,64,(66)(67)(68)71,72,74,79,(84)(85)(86) of the studies showed a significantly higher risk for HNC in subjects with the null GSTM1 genotype than in subjects with the positive genotype. No studies showed a significantly lower risk in patients with the null GSTM1 genotype than in those with the positive genotype.…”

Section: Introductionmentioning

confidence: 98%

“…The 105Val form shows altered affinity and enzymatic activity for some substrates. Four (18%) (77,(88)(89)(90) of the 22 studies (18,20,21,25,31,33,63,69,73,77,80,82,84,(87)(88)(89)(90)(91)(92)(93)(94) NATs. Two NAT isozymes, NAT1 and NAT2, are polymorphic and catalyze both O-acetylation (activation) and N-acetylation (usually detoxification) of aromatic and heterocyclic amine carcinogens.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Genetic polymorphisms and head and neck cancer risk (Review)

Hiyama¹,

Yoshihara²,

Tanaka³

et al. 2008

Int J Oncol

View full text Add to dashboard Cite

Abstract. The aim of this report is to review and evaluate, in a comprehensive manner, the published data regarding the contribution of genetic polymorphisms to risk of head and neck cancer (HNC). All relevant studies available in MEDLINE and published before July 2007 were identified. Studies carried out in humans that compared HNC patients with at least 1 standard control group were considered for analysis. Two hundred and eighteen publications and 3 published metaanalyses were identified. Seventy-five (34%) studies were conducted in Asian, 72 (33%) in American, and 68 (31%) in European countries. The most widely studied gene was GSTM1 (58 studies), followed by GSTT1 (42 studies), GSTP1 (codon 105, 22 studies) and p53 (codon 72, 20 studies). GSTM1, GSTT1, GSTP1, XRCC1 codons 194 and 399, and CYP1A1 codon 462 were examined by meta-analyses, and significant relations were found between the GSTM1-null genotype and an increased risk for HNC. In addition, increased risk for HNC was associated consistently with the ALDH2*1/*2, p53 codon 72 Pro/Pro and EPHX1 codon 113 Tyr/His and His/His genotypes. Cohort studies that simultaneously consider multiple genetic and environmental factors possibly involved in carcinogenesis of the head and neck are needed to ascertain not only the relative contribution of these factors to tumor development but also the contributions of their putative interactions. IntroductionHead and neck cancers (HNCs), including cancers of the oral cavity, pharynx and larynx, represent the 6 most frequent cancers and the seventh leading cause of cancer-related death worldwide. There are approximately 540,000 new cases and 271,000 deaths annually worldwide for a mortality of approximately 50% (1). HNCs represent approximately 3% of all cancers in the United States whereas these cancers are much more prevalent in other areas of the world, such as India, Thailand and Brazil (1,2). Standard therapeutic approaches, which focus on surgery, irradiation and chemotherapy (alone or in combination), have been modified over the last 30 years; however, the overall survival of HNC patients has not improved substantially. For patients affected by early-stage cancers with a high disease-specific survival rate, secondary tumors represent the most common cause of death (3). Furthermore, patients with advanced cancers have a high risk of primary treatment failure and death.Development of HNC is a multifactorial process associated with a variety of risk factors. Major risk factors in developed countries include smoking tobacco and drinking alcohol, and chewing betel quid (4,5). For tobacco smoking, a dose-response trend has been reported. Relative risks of developing laryngeal and oropharyngeal cancers are 1.8 and 1.3, respectively, for persons who smoke ≤30 cigarettes per day and 7.7 and 2.9, respectively, for persons who smoke >30 cigarettes per day compared with non-smokers (6). Alcohol consumption is also linked to increased risk of HNCs. For persons who consume >4 drinks (=47.5 g of pure ethanol) per day, the relati...

show abstract

Charge density effects on polyelectrolyte dynamic rheology

Harrington

2007

J of Applied Polymer Sci

View full text Add to dashboard Cite

The dynamic rheological properties of an uncharged polymer and charged polyelectrolytes were evaluated in salt-free water at various concentrations above the entanglement concentration. A poly(acrylic acid) homopolymer was used as the uncharged polymer and was ionized to anionic poly(acrylic acid-co-sodium acrylate) at five levels of ionization (0.05, 0.10, 0.15, 0.30, and 0.50). The polymers exhibited a terminal region at a low frequency and a plateau region at a high frequency. The dynamic data for the nonionic parent and all charged polymers could be reduced to a master curve, which indicated a similar distribution of relaxation times for the nonionic and charged polymers. The shear modulus, relaxation time, and zero shear viscosity properties exhibited a concentration and charge density dependence. Higher power-law exponents for the rheological properties were noted for the nonionic polymer versus the charged derivatives. The number of mechanically active entanglements per number of chains increased with the polymer concentration and charge density. The total number of mechanically active entanglements per number of chains that occurred because of imposing a charge to the nonionic parent did not change with increased concentration, and this indicated a different entanglement mechanism for charged polymers in comparison with their nonionic parent.

show abstract

Glutathione S-Transferase Polymorphisms and the Synergy of Alcohol and Tobacco in Oral, Pharyngeal, and Laryngeal Carcinoma

Cited by 73 publications

References 46 publications

A Genotype-Phenotype Examination of Cyclin D1 on Risk and Outcome of Squamous Cell Carcinoma of the Head and Neck

A Genotype-Phenotype Examination of Cyclin D1 on Risk and Outcome of Squamous Cell Carcinoma of the Head and Neck

Genetic polymorphisms and head and neck cancer risk (Review)

Charge density effects on polyelectrolyte dynamic rheology

Contact Info

Product

Resources

About