Glutathione in Brain Disorders and Aging

Iskusnykh, Igor Y.; Zakharova, A. A.; Pathak, Dhruba

doi:10.3390/molecules27010324

Cited by 112 publications

(59 citation statements)

References 92 publications

(81 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These data are consistent with previous evidence reporting an age-related decline in GSH levels both in the brain and the liver of SAM mice, along with other antioxidant molecules [ 194 ]. In humans, this impaired glutathione homeostasis might be involved in the pathogenesis of brain disorders, including age-related neurodegeneration [ 195 ].…”

Section: Resultsmentioning

confidence: 99%

The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence

et al. 2022

View full text Add to dashboard Cite

Cellular senescence is an irreversible state of cell cycle arrest occurring in response to stressful stimuli, such as telomere attrition, DNA damage, reactive oxygen species, and oncogenic proteins. Although beneficial and protective in several physiological processes, an excessive senescent cell burden has been involved in various pathological conditions including aging, tissue dysfunction and chronic diseases. Oxidative stress (OS) can drive senescence due to a loss of balance between pro-oxidant stimuli and antioxidant defences. Therefore, the identification and characterization of antioxidant compounds capable of preventing or counteracting the senescent phenotype is of major interest. However, despite the considerable number of studies, a comprehensive overview of the main antioxidant molecules capable of counteracting OS-induced senescence is still lacking. Here, besides a brief description of the molecular mechanisms implicated in OS-mediated aging, we review and discuss the role of enzymes, mitochondria-targeting compounds, vitamins, carotenoids, organosulfur compounds, nitrogen non-protein molecules, minerals, flavonoids, and non-flavonoids as antioxidant compounds with an anti-aging potential, therefore offering insights into innovative lifespan-extending approaches.

show abstract

Section: Resultsmentioning

confidence: 99%

The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence

et al. 2022

View full text Add to dashboard Cite

show abstract

“…16 The enzymatic antioxidant system superoxide dismutase (SOD) and glutathione GSH can protect nerves from oxidative stress damage. 17,18 The structure of scaffold has significant impacts on its physical/biological properties. Microstructure plays another vital role in tissue repair scaffolds.…”

Section: Introductionmentioning

confidence: 99%

Citric acid cross‐linked chitosan for inhibiting oxidative stress after nerve injury

Liu

Dai

2022

J Biomed Mater Res

View full text Add to dashboard Cite

Scaffold design is particularly important and necessary for soft tissue repair such as nerve tissue repair. In this article, we designed and manufactured a macroporous chitosan‐based hydrogel with excellent cell compatibility and antioxidant properties. Here, the chitosan (CS) based hydrogel is obtained by repeated freezing and thawing using citric acid (CA) as a cross‐linking agent. We have evaluated the effects of citric acid content on the physical and chemical properties of hydrogels through mechanical properties and scanning electron microscopy. CA‐CS hydrogel shows a macroporous structure, as the citric acid increases, the mechanical strength increases and the pore size decreases. In vitro cell experiments show that CA‐CS hydrogel partakes positive effects on cell survival, adhesion and proliferation, as well as antioxidant properties. All results provide a basis for the construction of porous chitosan‐based hydrogels, while demonstrating a promising approach to deal with oxidative stress in nerve injury.

show abstract

“…The reduction in GSH reflects a reduced antioxidant capacity of cells, which may lead to increased ROS and elicits oxidative stress and neuroinflammation in the hippocampus. In the mammalian brain, glial cells of the cortex and hippocampus have been shown to have the highest concentration of GSH [ 69 ]. Recent studies show that GSH levels decrease in the hippocampus and cortex with age and age-related neurological disorders, and are found to be correlated with a decline in cognitive function [ 69 , 70 ].…”

Section: Discussionmentioning

confidence: 99%

“…In the mammalian brain, glial cells of the cortex and hippocampus have been shown to have the highest concentration of GSH [ 69 ]. Recent studies show that GSH levels decrease in the hippocampus and cortex with age and age-related neurological disorders, and are found to be correlated with a decline in cognitive function [ 69 , 70 ]. Further, the production of 4-HNE by lipid peroxidation has been associated with oxidative stress-induced neuroinflammation in aging and neurodegenerative diseases [ 71 , 72 ].…”

Section: Discussionmentioning

confidence: 99%

Deltamethrin-Evoked ER Stress Promotes Neuroinflammation in the Adult Mouse Hippocampus

Hossain

Toltin

Gamba

et al. 2022

Cells

View full text Add to dashboard Cite

Endoplasmic reticulum (ER) stress and neuroinflammation are involved in the pathogenesis of many neurodegenerative disorders. Previously, we reported that exposure to pyrethroid insecticide deltamethrin causes hippocampal ER stress, apoptosis, a reduction in neurogenesis, and learning deficits in adult male mice. Recently, we found that deltamethrin exposure also increases the markers of neuroinflammation in BV2 cells. Here, we investigated the potential mechanistic link between ER stress and neuroinflammation following exposure to deltamethrin. We found that repeated oral exposure to deltamethrin (3 mg/kg) for 30 days caused microglial activation and increased gene expressions and protein levels of TNF-α, IL-1β, IL-6, gp91phox, 4HNE, and iNOS in the hippocampus. These changes were preceded by the induction of ER stress, as the protein levels of CHOP, ATF-4, and GRP78 were significantly increased in the hippocampus. To determine whether induction of ER stress triggers the inflammatory response, we performed an additional experiment with mouse microglial cell (MMC) line. MMCs were treated with 0–5 µM deltamethrin for 24–48 h in the presence or absence of salubrinal, a pharmacological inhibitor of the ER stress factor eIF2α. We found that salubrinal (50 µM) prevented deltamethrin-induced ER stress, as indicated by decreased levels of CHOP and ATF-4, and attenuated the levels of GSH, 4-HNE, gp91phox, iNOS, ROS, TNF-α, IL-1β, and IL-6 in MMCs. Together, these results demonstrate that exposure to deltamethrin leads to ER stress-mediated neuroinflammation, which may subsequently contribute to neurodegeneration and cognitive impairment in mice.

show abstract

Glutathione in Brain Disorders and Aging

Cited by 112 publications

References 92 publications

The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence

The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence

Citric acid cross‐linked chitosan for inhibiting oxidative stress after nerve injury

Deltamethrin-Evoked ER Stress Promotes Neuroinflammation in the Adult Mouse Hippocampus

Contact Info

Product

Resources

About