2021
DOI: 10.18632/aging.203509
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Glutathione is an aging-related metabolic signature in the mouse kidney

Abstract: The ability to maintain systemic metabolic homeostasis through various mechanisms represents a crucial strength of kidneys in the study of metabolic syndrome or aging. Moreover, age-associated kidney failure has been widely accepted. However, efforts to demonstrate aging-dependent renal metabolic rewiring have been limited. In the present study, we investigated aging-related renal metabolic determinants by integrating metabolomic and transcriptomic data sets from kidneys of young (3 months, … Show more

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Cited by 8 publications
(9 citation statements)
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“…To address this issue, we visualized our data through a correlation coefficient network and quantified the stress centrality measures of each node, which represents either the metabolite or the microbiome. The number of shortest paths flowing through a node is known as stress centrality, and it can be used as a proxy indicator of importance 24 . In this network analysis, we identified several key factors, such as glycine, mannose, LCA, TDCA, glucose, Granulicatella , Fusobacterium , St. anginosus , and B. infantis (Figure S7B).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…To address this issue, we visualized our data through a correlation coefficient network and quantified the stress centrality measures of each node, which represents either the metabolite or the microbiome. The number of shortest paths flowing through a node is known as stress centrality, and it can be used as a proxy indicator of importance 24 . In this network analysis, we identified several key factors, such as glycine, mannose, LCA, TDCA, glucose, Granulicatella , Fusobacterium , St. anginosus , and B. infantis (Figure S7B).…”
Section: Resultsmentioning
confidence: 99%
“…The number of shortest paths flowing through a node is known as stress centrality, and it can be used as a proxy indicator of importance. 24 In this network analysis, we identified several key factors, such as glycine, mannose, LCA, TDCA, glucose, Granulicatella, Fusobacterium, St. anginosus, and B. infantis (Figure S7B).…”
Section: Integration Of the Stool Microbiome And Serum Metabolomementioning
confidence: 99%
“…This type of metabolism was also increased during growth in fast-growing chicken (Gallus gallus) strains compared to slow-growing strains (Willson et al, 2018). Moreover, the metabolism of nicotinate and nicotinamide derivatives was significantly decreased in kidneys of old mice compared to young mice (Ahn et al, 2021). Dietary supplementation of nicotinamide riboside (an NAD + precursor) improved mitochondrial function and rejuvenated muscle stem cells in aged mice (Zhang et al, 2016).…”
Section: Discussionmentioning
confidence: 99%
“…16 Researchers have determined that renal glutathione metabolism defects are a characteristic sign of renal aging by comparing the renal transcriptome data of young and old C57BL/6 mice. 17 Moreover, N6-methyladenosine (m6A) is the most common RNA modification in eukaryotes and prokaryotes. Emerging evidence suggests that m6A methylation plays a critical role in cancer through various mechanisms.…”
Section: Introductionmentioning
confidence: 99%