2017
DOI: 10.26444/jpccr/81277
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Glutathione level and glutathione reductase activity in serum of coronary heart disease patients

Abstract: level and glutathione reductase activity in serum of coronary heart disease patients. J Pre-Clin Clin Res. 2017; 11(2): 103-105. doi: 10.26444/jpccr/81277 Abstract Introduction. Oxidative stress induced by the generation of excess reactive oxygen species is one of the cause of atherosclerosis finally leading to coronary heart disease (CHD). Glutathione reductase (GR), a flavoprotein antioxidant enzyme, regenerates glutathione (GSH) from its oxidized form, which is essential for scavenging of hydrogen peroxide … Show more

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Cited by 20 publications
(7 citation statements)
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“…Similarly, glutathione reductase (GR) regenerates intracellular GSH by reducing oxidized glutathione (GSSG) in the presence of NADPH and flavine adenine dinucleotide (FAD) [49]. On the other hand, glutathione S-transferases (GST) catalyzes the conjugation of the reduced form of glutathione (GSH) to endogenous and xenobiotic substrates for the purpose of detoxification [49,58]. Our results are compatible with other works, confirming dysregulation of pro-and antioxidants homeostasis during ischemia and reperfusion.…”
Section: Discussionsupporting
confidence: 88%
“…Similarly, glutathione reductase (GR) regenerates intracellular GSH by reducing oxidized glutathione (GSSG) in the presence of NADPH and flavine adenine dinucleotide (FAD) [49]. On the other hand, glutathione S-transferases (GST) catalyzes the conjugation of the reduced form of glutathione (GSH) to endogenous and xenobiotic substrates for the purpose of detoxification [49,58]. Our results are compatible with other works, confirming dysregulation of pro-and antioxidants homeostasis during ischemia and reperfusion.…”
Section: Discussionsupporting
confidence: 88%
“…The results shown in Table (1) and Table (2) indicate a significant decrease (P≤0.01) In the level of clutathione in the serum of patients with vascular disease for both sexes and the reason may be due to the condition of oxidative stress usually associated with vascular disease. In the case of oxidative stress, free radicals such as ROS (Reactive Oxygen Species), which are usually produced as by-products of oxidative metabolic processes, are enhanced by various environmental factors such as UV radiation, ionic radiation, pollutants and heavy metals [50,51] GSH, along with other antioxidants, works to remove free radicals by reducing these roots, which in turn is oxidized to GSSG. This process leads to lower serum levels of patients suffering from oxidative stress [52].…”
Section: Resultsmentioning
confidence: 99%
“…The results shown in Table (1) and Table (2) indicate a significant decrease (P≤0.01) In the level of clutathione in the serum of patients with vascular disease for both sexes and the reason may be due to the condition of oxidative stress usually associated with vascular disease. In the case of oxidative stress, free radicals such as ROS (Reactive Oxygen Species), which are usually produced as by-products of oxidative metabolic processes, are enhanced by various environmental factors such as UV radiation, ionic radiation, pollutants and heavy metals [50,51] GSH, along with other antioxidants, works to remove free radicals by reducing these roots, which in turn is oxidized to GSSG. This process leads to lower serum levels of patients suffering from oxidative stress [52].…”
Section: Resultsmentioning
confidence: 99%