Glutathione Metabolism in Men under Psychological Stress

Persky, Harold

doi:10.1097/00006842-195411000-00003

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…The findings obtained by our study support this concept. The mbmdr method discovered that well-known environmental risk factors for ischemic stroke, such as chronic stress [58], physical inactivity [59], cigarette smoking [60], alcohol abuse [61], and insufficient consumption of fresh vegetables and fruits [62], showed the strongest contribution to disease development in combination with polymorphisms of the GCLC and GCLM genes, as well as some GWAS loci. The vast majority of GxE models comprise combinations of one or more of these environmental factors.…”

Section: Discussionmentioning

confidence: 99%

“…Regular consumption of fresh vegetables and fruits, which contain up to 70% of dietary glutathione and its precursors, including a balanced amount of amino acids, vitamins, minerals, and phytochemicals, contributes to a significant increase in endogenous glutathione levels [71,75]. Interestingly, increasing the intake of fresh fruits and vegetables (e.g., green leafy vegetables and citrus fruits, including juice) by one serving per day is associated with a 6% reduction in the risk of ischemic stroke [62].…”

Section: Discussionmentioning

confidence: 99%

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The Impact of Genetic Polymorphisms in Glutamate-Cysteine Ligase, a Key Enzyme of Glutathione Biosynthesis, on Ischemic Stroke Risk and Brain Infarct Size

Polonikov

Bocharova

Azarova

et al. 2022

Life

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The purpose of this pilot study was to explore whether polymorphisms in genes encoding the catalytic (GCLC) and modifier (GCLM) subunits of glutamate-cysteine ligase, a rate-limiting enzyme in glutathione synthesis, play a role in the development of ischemic stroke (IS) and the extent of brain damage. A total of 1288 unrelated Russians, including 600 IS patients and 688 age- and sex-matched healthy subjects, were enrolled for the study. Nine common single nucleotide polymorphisms (SNPs) of the GCLC and GCLM genes were genotyped using the MassArray-4 system. SNP rs2301022 of GCLM was strongly associated with a decreased risk of ischemic stroke regardless of sex and age (OR = 0.39, 95%CI 0.24–0.62, p < 0.0001). Two common haplotypes of GCLM possessed protective effects against ischemic stroke risk (p < 0.01), but exclusively in nonsmoker patients. Infarct size was increased by polymorphisms rs636933 and rs761142 of GCLC. The mbmdr method enabled identifying epistatic interactions of GCLC and GCLM gene polymorphisms with known IS susceptibility genes that, along with environmental risk factors, jointly contribute to the disease risk and brain infarct size. Understanding the impact of genes and environmental factors on glutathione metabolism will allow the development of effective strategies for the treatment of ischemic stroke and disease prevention.

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