Glutathione-responsive biodegradable polyurethane nanoparticles for lung cancer treatment

Iyer, Roshni; Nguyên, Tam; Padanilam, Dona; Xu, Chunli; Saha, Debabrata; Nguyen, Kytai T.; Hong, Yi

doi:10.1016/j.jconrel.2020.02.021

Cited by 79 publications

(40 citation statements)

References 36 publications

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“…In addition, when compared to the same concentration of free CDDP, the survival rate of NP-treated A549 cells was significantly reduced in vitro. Moreover, the study also showed that NPs have a higher biodistribution in the tumor area and a stronger tumorsuppressing effect [85]. Lipoplatin is a liposome nanoformulation of CDDP.…”

Section: Nanomedicine and Anticancer Drugsmentioning

confidence: 87%

Recent applications and strategies in nanotechnology for lung diseases

et al. 2021

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Lung diseases, including COVID-19 and lung cancers, is a huge threat to human health. However, for the treatment and diagnosis of various lung diseases, such as pneumonia, asthma, cancer, and pulmonary tuberculosis, are becoming increasingly challenging. Currently, several types of treatments and/or diagnostic methods are used to treat lung diseases; however, the occurrence of adverse reactions to chemotherapy, drug-resistant bacteria, side effects that can be significantly toxic, and poor drug delivery necessitates the development of more promising treatments. Nanotechnology, as an emerging technology, has been extensively studied in medicine. Several studies have shown that nano-delivery systems can significantly enhance the targeting of drug delivery. When compared to traditional delivery methods, several nanoparticle delivery strategies are used to improve the detection methods and drug treatment efficacy. Transporting nanoparticles to the lungs, loading appropriate therapeutic drugs, and the incorporation of intelligent functions to overcome various lung barriers have broad prospects as they can aid in locating target tissues and can enhance the therapeutic effect while minimizing systemic side effects. In addition, as a new and highly contagious respiratory infection disease, COVID-19 is spreading worldwide. However, there is no specific drug for COVID-19. Clinical trials are being conducted in several countries to develop antiviral drugs or vaccines. In recent years, nanotechnology has provided a feasible platform for improving the diagnosis and treatment of diseases, nanotechnology-based strategies may have broad prospects in the diagnosis and treatment of COVID-19. This article reviews the latest developments in nanotechnology drug delivery strategies in the lungs in recent years and studies the clinical application value of nanomedicine in the drug delivery strategy pertaining to the lung.

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Section: Nanomedicine and Anticancer Drugsmentioning

confidence: 87%

Recent applications and strategies in nanotechnology for lung diseases

et al. 2021

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“…Tunable degradation for specific applications such as for example, cancer treatment was designed by incorporation of various stimuli-responsive bonds in the SS or HS of the PU architectures or molecules. We can find for instance imine (C N) or sodium bicarbonate (NaHCO3) [ 168 , 169 ], disulfide (S–S) [ [170] , [171] , [172] ], and selenium-inserted polymers [ 173 ], triggered by pH, redox or light, respectively. In this case, the degradation rate and drug release depend on the type and amount of stimuli-responsive systems in the PU backbone.…”

Section: Conventional (Fossil-based) Pu For Biomedical Applicationsmentioning

confidence: 99%

Biobased polyurethanes for biomedical applications

Wendels

Avérous

2021

Bioactive Materials

241

173

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Polyurethanes (PUs) are a major family of polymers displaying a wide spectrum of physico-chemical, mechanical and structural properties for a large range of fields. They have shown suitable for biomedical applications and are used in this domain since decades. The current variety of biomass available has extended the diversity of starting materials for the elaboration of new biobased macromolecular architectures, allowing the development of biobased PUs with advanced properties such as controlled biotic and abiotic degradation. In this frame, new tunable biomedical devices have been successfully designed. PU structures with precise tissue biomimicking can be obtained and are adequate for adhesion, proliferation and differentiation of many cell's types. Moreover, new smart shape-memory PUs with adjustable shape-recovery properties have demonstrated promising results for biomedical applications such as wound healing. The fossil-based starting materials substitution for biomedical implants is slowly improving, nonetheless better renewable contents need to be achieved for most PUs to obtain biobased certifications. After a presentation of some PU generalities and an understanding of a biomaterial structure-biocompatibility relationship, recent developments of biobased PUs for non-implantable devices as well as short- and long-term implants are described in detail in this review and compared to more conventional PU structures.

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“…These systems use specific stimulus signals to promote the directional delivery of NPs to tumors and to boost the anticancer activities of NP-carried drugs ( 31 , 74 ). The signals can be tumor intrinsic, such as an increased glutamine level ( 75 ), a decreased pH value ( 76 ), and hypoxia ( 77 ), or tumor extrinsic, such as a light source ( 78 ), a heat source ( 79 ), a magnetic field ( 80 ), or ultrasound ( 81 ). Among them, light-responsive systems may be the most well-studied systems because they can be readily controlled in a spatiotemporal manner, resulting in directional transport, improved tumor penetration and distribution, and controlled release of NP-carried drugs.…”

Section: Nanotechnology In Cancer Therapymentioning

confidence: 99%

Engineering Macrophages via Nanotechnology and Genetic Manipulation for Cancer Therapy

et al. 2022

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Macrophages play critical roles in tumor progression. In the tumor microenvironment, macrophages display highly diverse phenotypes and may perform antitumorigenic or protumorigenic functions in a context-dependent manner. Recent studies have shown that macrophages can be engineered to transport drug nanoparticles (NPs) to tumor sites in a targeted manner, thereby exerting significant anticancer effects. In addition, macrophages engineered to express chimeric antigen receptors (CARs) were shown to actively migrate to tumor sites and eliminate tumor cells through phagocytosis. Importantly, after reaching tumor sites, these engineered macrophages can significantly change the otherwise immune-suppressive tumor microenvironment and thereby enhance T cell-mediated anticancer immune responses. In this review, we first introduce the multifaceted activities of macrophages and the principles of nanotechnology in cancer therapy and then elaborate on macrophage engineering via nanotechnology or genetic approaches and discuss the effects, mechanisms, and limitations of such engineered macrophages, with a focus on using live macrophages as carriers to actively deliver NP drugs to tumor sites. Several new directions in macrophage engineering are reviewed, such as transporting NP drugs through macrophage cell membranes or extracellular vesicles, reprogramming tumor-associated macrophages (TAMs) by nanotechnology, and engineering macrophages with CARs. Finally, we discuss the possibility of combining engineered macrophages and other treatments to improve outcomes in cancer therapy.

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Glutathione-responsive biodegradable polyurethane nanoparticles for lung cancer treatment

Cited by 79 publications

References 36 publications

Recent applications and strategies in nanotechnology for lung diseases

Recent applications and strategies in nanotechnology for lung diseases

Biobased polyurethanes for biomedical applications

Engineering Macrophages via Nanotechnology and Genetic Manipulation for Cancer Therapy

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