Glutathione responsive nitric oxide release for enhanced photodynamic therapy by a porphyrinic MOF nanosystem

Xia, Mengtong; Yan, Yu; Pu, Haiyan; Du, Xuening; Liang, Jingyi; Sun, Yaning; Zheng, Jing; Yuan, Yue

doi:10.1016/j.cej.2022.136295

Cited by 44 publications

(20 citation statements)

References 39 publications

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“…Fortunately, the development of catalysts, including catalytic nanomaterials and nano‐enzymes, provides a new way to build a controllable and persistent NO‐releasing system. [ 42–44 ] Recent research found that advanced catalytic nanomaterials (including nanozymes) not only have the characteristics of high drug payload, low toxicity, good biocompatibility, and specific drug delivery through passive (enhanced permeability and retention, EPR) or active targeting but also own the capability of continuous releasing NO through catalytic reaction, which might significantly increase the feasibility of NO‐based therapies. [ 45–48 ] Within this context, there have been many efforts in designing and fabricating NO‐releasing platforms based on catalytic nanomaterials, and therefore, significant progress has been achieved in many biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Functional Nanomaterials for Catalytic Generation of Nitric Oxide: A Mini Review

Wang

Gan

et al. 2023

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As a gaseous second messenger, nitric oxide (NO) plays an important role in a series of signal pathways. Research on the NO regulation for various disease treatments has aroused wide concern. However, the lack of accurate, controllable, and persistent release of NO has significantly limited the application of NO therapy. Profiting from the booming development of advanced nanotechnology, a mass of nanomaterials with the properties of controllable release have been developed to seek new and effective NO nano‐delivery approaches. Nano‐delivery systems that generate NO through catalytic reactions exhibit unique superiority in terms of precise and persistent release of NO. Although certain achievements have been made in the catalytically active NO delivery nanomaterials, some basic but critical issues, such as the concept of design, are of low attention. Herein, an overview of the generation of NO through catalytic reactions and the design principles of related nanomaterials are summarized. Then, the nanomaterials that generate NO through catalytic reactions are classified. Finally, the bottlenecks and perspectives are also discussed in depth for the future development of catalytical NO generation nanomaterials.

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Section: Introductionmentioning

confidence: 99%

Recent Advances in Functional Nanomaterials for Catalytic Generation of Nitric Oxide: A Mini Review

Wang

Gan

et al. 2023

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“…These characters of NO made itself a strong therapeutic agent in anti-tumor, anti-bacterial and anti-fungal applications. [13][14][15][16][17] In addition, NO was reported to enhance the conventional therapy in different ways. Yu et al reported a mesoporous polydopamine nanocomposite bearing deferoxamine and NO-donation macromolecular for NO enhanced antibacterial chemo-photothermal therapy.…”

Section: Introductionmentioning

confidence: 99%

“…These reactive substances will lead to intense membrane damage by causing oxidative stress and nitrosative stress. These characters of NO made itself a strong therapeutic agent in anti‐tumor, anti‐bacterial and anti‐fungal applications [13–17] . In addition, NO was reported to enhance the conventional therapy in different ways.…”

Section: Introductionmentioning

confidence: 99%

“…However, under higher NO concentrations, unstable NO radicals (NO − ) and various highly reactive nitrogen oxides (e. g., ONOO − , N 2 O 3 , etc.) will be formed [13] . These reactive substances will lead to intense membrane damage by causing oxidative stress and nitrosative stress.…”

Section: Introductionmentioning

confidence: 99%

“…will be formed. [13] These reactive substances will lead to intense membrane damage by causing oxidative stress and nitrosative stress. These characters of NO made itself a strong therapeutic agent in anti-tumor, anti-bacterial and anti-fungal applications.…”

Section: Introductionmentioning

confidence: 99%

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Roxarsone Delivery Nanocomposite Based on Nitrite‐Functionalized Mesoporous Polydopamine for Multidrug‐Resistant Bacterial Infections via Enhanced Chemo‐Photothermal Therapy

et al. 2023

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Current treatments for infections caused by multidrug‐resistant bacteria still remain challenging and therapeutic materials with high efficacy are of demand. Herein, a bactericidal nanocomposite was constructed by loading Roxarsone (ROX) onto nitrosylated mesoporous polydopamine (named mPDA@NO‐ROX). The designed nanocomposite exhibited considerable photothermal effect and controlled NO and ROX co‐delivery under the irradiation of near‐infrared laser (NIR) to achieve enhanced chemo‐photothermal antibacterial therapy. The in vitro antibacterial evaluation of the mPDA@NO‐ROX demonstrated the effective elimination of the Gram‐negative tetracycline‐resistant Escherichia coil and Gram‐positive methicillin‐resistant Staphylococcus aureus under mild NIR irradiation compared to merely ROX loaded unmodified mPDA, indicating the NO enhanced chemo‐photothermal therapy. In addition, the cytotoxicity experiments indicated that mPDA@NO‐ROX exhibited only 5 % of hemolysis rate and high cell viability at 1 mg mL−1 against mammalian fibroblasts, suggesting the excellent biocompatibility. In conclusion, the mPDA@NO‐ROX could be a promising candidate for anti‐infection therapy of multidrug‐resistant bacteria.

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Antioxidants in Cardiovascular Disease

Firdous,

Pal

2024

Antioxidants

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Glutathione responsive nitric oxide release for enhanced photodynamic therapy by a porphyrinic MOF nanosystem

Cited by 44 publications

References 39 publications

Recent Advances in Functional Nanomaterials for Catalytic Generation of Nitric Oxide: A Mini Review

Recent Advances in Functional Nanomaterials for Catalytic Generation of Nitric Oxide: A Mini Review

Roxarsone Delivery Nanocomposite Based on Nitrite‐Functionalized Mesoporous Polydopamine for Multidrug‐Resistant Bacterial Infections via Enhanced Chemo‐Photothermal Therapy

Antioxidants in Cardiovascular Disease

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