Glutathione S-Transferase (GSTM1, GSTT1) Genes Polymorphisms Associated with Vitiligo Disease in Thi Qar Province/South of Iraq

Jalood, Hayder Hussein; AL-Rikabi, Hassan R; Al-Badran, Adnan Issa; Kawen, Ahmed Abdulhussein

doi:10.20546/ijcmas.2016.508.017

Cited by 2 publications

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“…The GSTT1 genes located on chromosome 22q11.23 coding the theta class of enzymes [19]. many studies showed the link between the lack of enzyme activity in GSTM1 and GSTT1 and the susceptibility to development various types of skin disease, such as vitiligo [20,21,22], systemic lupus erythematosus LE [23,24]. Few studies have looked to the associated between a null genotype of GSTM1,GSTT1 genes and the occurrence of psoriasis [25].…”

Section: Introductionmentioning

confidence: 99%

Association of GSTM1 , GSTT1 Genes Polymorphisms and Risk of Psoriasis in Thi Qar Province / Iraq

2019

University of Thi-Qar Journal of Medicine

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Psoriasis is a ,chronic inflammatory, and proliferative skin disorder with a not entirely comprehended etiology. The aim of present study was to investigate the clinical features and estimate the association between null of GSTM1, GSTT1 genotypes and the development of psoriasis in Dhi Qar province. This study included 100 psoriasis patients and 100 healthy (mean age 29.08±16.46 and 31.8±11.2 respectively). Early onset was predominant (71%) than the late onset (mean of age onset 24.97±15.6). 51% of patients were males , 49% were females. Among cases 80% were non smoker, 20% were smoker. No significant between patient and control according to place of residence. Psoriasis vulgaris found in 65% of cases. Positive family history appear in 13% of patients. More of patients (56%) were exposure to stress during lifestyle. 5% patients were synchronized viral and bacterial infections. Analysis of GSTM1 , GSTT1 genotype showed no statistically significant with psoriasis susceptibility (OR=0.56; 95%, CI=0.32-0.99) and (OR=0.48; 95%, CI=0.25-0.92). Also the combined effect of GSTM1/GSTT1 null genotypes were found no increased risk of psoriasis (OR=0.55; 95%, CI=0.20-1.51).

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Section: Introductionmentioning

confidence: 99%

Association of GSTM1 , GSTT1 Genes Polymorphisms and Risk of Psoriasis in Thi Qar Province / Iraq

2019

University of Thi-Qar Journal of Medicine

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Vitiligo susceptibility at workplace and in daily life: the contribution of oxidative stress gene polymorphisms

Chiarella

2019

biomed dermatol

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Objective: Vitiligo is a frequently underestimated and little known dermal disease whose symptoms appear as white patches on several skin areas of the body. In this review, the impact of idiopathic and chemical-induced vitiligo at workplace and in daily life is discussed. Also, the influence of selected oxidative stress gene polymorphisms on melanocyte damage is described to understand their involvement in the disease. Methods: A PubMed search was carried out to select the journal articles reporting an association between specific oxidative stress polymorphic genes and vitiligo. Results: The double-null glutathione S-transferase T1 and M1 genotypes are associated with vitiligo while the relationship between nuclear factor erythroid 2-related factor 2, heme oxygenase, catalase and superoxide dismutase gene polymorphisms and the disease should be confirmed by further studies. Conclusions: The polymorphic genes analysed here may have a role in the susceptibility of patients affected by vitiligo, while little is known about the affected workers, due to the lack of epidemiologic data on these subjects. However, the similarity of the skin lesions observed in both groups might have in common some genetic factors making all these individuals susceptible to the development of vitiligo, regardless of the disease-triggering factor.

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Glutathione S-Transferase (GSTM1, GSTT1) Genes Polymorphisms Associated with Vitiligo Disease in Thi Qar Province/South of Iraq

Cited by 2 publications

References 0 publications

Association of GSTM1 , GSTT1 Genes Polymorphisms and Risk of Psoriasis in Thi Qar Province / Iraq

Association of GSTM1 , GSTT1 Genes Polymorphisms and Risk of Psoriasis in Thi Qar Province / Iraq

Vitiligo susceptibility at workplace and in daily life: the contribution of oxidative stress gene polymorphisms

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