Glutathione S transferase (GSTP 1, GSTM 1, and GSTT 1) gene polymorphisms in Egyptian patients with acute myeloid leukemia

Nasr, Aml S.; Sami, Rania M.; Ibrahim, N. A.; Darwish, Dalia

doi:10.4103/0019-509x.178408

Cited by 23 publications

(18 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this case-control study, we found that the GSTM1 and GSTT1 deletion polymorphisms were associated with risk of AML these findings are partially agree with study done in Egypt [13] which demonstrated that GSTM1 null or GSTT1 null genotypes may be considered independent risk factors for AML. This study indicated GSTs polymorphisms were promising candidate biomarkers for evaluating the AML risk.…”

Section: Discussionsupporting

confidence: 90%

GSTM1 and GSTT1 Polymorphisms and Susceptibility to Acute Myeloid Leukemia: A Case-control Study of the Sudanese Population

Babekir

Abdelateif

Adelrahim

et al. 2019

Asian Pac J Cancer Biol

View full text Add to dashboard Cite

Background: Glutathione S-transferase (GST) enzyme levels are associated with risk of many types of cancers, including hematological malignancies. In this study we here aimed to investigate the relationship between GSTM1 and GSTT1 polymorphisms and the risk of AML. Conflicts in the published results and the absence of similar in-depth studies in Sudan prompted us to perform the present case-control study to determine the frequency of GSTM1 and GSTT1 polymorphisms in AML patients and their possible association with AML in a Sudanese population.Materials and Methods: A total of 40 patients with AML and 40 control subjects were enrolled in this study. Blood samples were collected from all patients in EDTA containing tubes. Genomic DNA was extracted from all blood samples using salting out method. Genotyping for detection of GSTM1, and GSTT1 polymorphisms was performed for both patients and controls using a multiplex PCR. Results: We reported that there is an association between the GSTM1 null genotype and AML risk (OR= 2.7, 95% CI= 1.2-6.04; P.value = 0.012), the GSTT1 null genotype appeared also to have an influence in the development of AML (OR= 4.93, 95% CI= 1.6-15.07; P.value = 0.005).Conclusion: These findings indicate that genetic variants of GSTM1 and GSTT1 genes may increase individual susceptibility to AML.

show abstract

Section: Discussionsupporting

confidence: 90%

GSTM1 and GSTT1 Polymorphisms and Susceptibility to Acute Myeloid Leukemia: A Case-control Study of the Sudanese Population

Babekir

Abdelateif

Adelrahim

et al. 2019

Asian Pac J Cancer Biol

View full text Add to dashboard Cite

show abstract

“…Many conditions have been associated with the deletion polymorphisms in GSTM and G STT genes, including asthma ( Lima et al , 2010 ), male infertility ( Dordevic et al , 2010 ), end-stage renal disease ( Suvakov et al , 2013 ), leukemia ( Souza et al , 2008 ; Nasr et al , 2015 ) and lung cancer ( Sharma et al , 2015 ; Yang et al , 2015 ), among others.…”

Section: Introductionmentioning

confidence: 99%

Combined GSTM1 and GSTT1 null genotypes are strong risk factors for atherogenesis in a Serbian population

Grubisa¹,

Otašević²,

Vucinic³

et al. 2018

Genet. Mol. Biol.

View full text Add to dashboard Cite

Oxidative stress (OS) plays an important role in atherogenesis and since glutathione S-transferases (GSTs) provide protection against OS, we have tested the hypothesis that deletion polymorphisms in two GSTs (GSTM1 and GSTT1) may affect the risk of developing atherosclerosis. A total of 382 individuals (200 patients with atherosclerosis and 182 healthy controls) were included in this association study. Genomic DNA was isolated from peripheral blood cells or from buccal epithelial cells and genotyping was performed using multiplex-PCR or real-time PCR methods. GSTM1 null genotype was significantly more frequent in atherosclerotic patients than in controls (52.0% vs 34.1%) and individuals with the GSTM1 null genotype had an approximately 2-fold increase in atherosclerosis risk (OR: 2.1, 95%CI=1.39-3.17, P=0.0004). GSTT1 null genotype alone did not show a statistically significant effect on atherosclerosis risk modulation, but the association approached significance (OR: 1.57, 95%CI=0.94-2.64, P=0.08). The combined analysis showed that the presence of both genes had a protective effect against atherosclerosis (OR=0.55, 95%CI=0.37-0.83, P=0.005) while double null genotypes led to a robust atherosclerosis risk increase (OR: 8.14, 95%CI= 2.41-27.51, P < 0.0001). This study demonstrated that the GSTM1 null and combined GSTM1/GSTT1 null genotypes are susceptibility factors for development of atherosclerosis in a Serbian population.

show abstract

“…Previous studies revealed that the GSTM family of genes have critical roles in several cancer types. GSTM1 is highly polymorphic in humans and is associated with multiple cancer types, such as bladder and breast cancer, metabolic disorders and autoimmune diseases, as well as anticancer drugs response and resistance ( 28 ) GSTM1 deletion in humans was indicated to have a key role in bladder ( 29 ) and breast cancer ( 30 , 31 ), multiple sclerosis ( 32 ), severe early-onset mental disorders including schizophrenia-spectrum disorder, bipolar disorder with psychotic symptoms or first-episode psychosis ( 33 ) and acute myeloid leukemia ( 34 ). Csejtei et al ( 35 ) identified that GSTM1 may be a prognostic biomarker in clinical diagnostics as well as a potential therapeutic candidate in colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Identification and verification of the prognostic value of the glutathione S‑transferase Mu genes in gastric cancer

Chen

Wang

et al. 2020

Oncol Lett

View full text Add to dashboard Cite

Gastric cancer (GC) is one of the most frequently diagnosed gastrointestinal cancer types in the world. Novel prognostic biomarkers are required to predict the progression of GC. Glutathione S-transferase Mu (GSTM) belongs to a family of phase II enzymes that have been implicated in a number of cancer types. However, the prognostic value of the GSTM genes has not been previously investigated in GC. The Cancer Genome Atlas (TCGA) was used to evaluate mRNA expression levels of GSTMs in GC tissue samples. Overall survival (OS) rates, hazard ratios (HRs) and 95% CIs were calculated using the Cox logistic regression model and Kaplan-Meier (KM) analysis was performed. In addition, the KM plotter online database was used to validate mRNA expression and the prognostic value of GSMT family members in patients with GC. To predict the function of GSTM genes in these patients, several bioinformatics tools, including the Database for Annotation, Visualization and Integrated Discovery, gene multiple association network integration algorithm, Search Tool for the Retrieval of Interacting Genes/Proteins, Gene Set Enrichment Analysis (GSEA), nomogram and genome-wide co-expression analysis were used. In the present study, high expression of GSTM5 was indicated to be strongly associated with lower OS in patients with GC, according to the TCGA and KM plotter online databases (HR=1.47, 95% CI: 1.06-2.04, P=0.021; and HR=1.69, 95% CI: 1.42-2.01, P=1.6x10-9 , respectively). The results from the GSEA and genome-wide co-expression analysis indicated that GSTM5 expression associated with several biological process terms, including 'adhesion', 'angiogenesis', 'apoptotic process', 'cell growth', 'proliferation', 'migration', 'Hedgehog signaling', 'MAPK signaling' and the 'TGF-β signaling pathway'. In conclusion, the present results indicated that GSTM5 may serve as a biomarker for GC prognosis and may be a potential therapeutic target for GC.

show abstract

Glutathione S transferase (GSTP 1, GSTM 1, and GSTT 1) gene polymorphisms in Egyptian patients with acute myeloid leukemia

Cited by 23 publications

References 1 publication

GSTM1 and GSTT1 Polymorphisms and Susceptibility to Acute Myeloid Leukemia: A Case-control Study of the Sudanese Population

GSTM1 and GSTT1 Polymorphisms and Susceptibility to Acute Myeloid Leukemia: A Case-control Study of the Sudanese Population

Combined GSTM1 and GSTT1 null genotypes are strong risk factors for atherogenesis in a Serbian population

Identification and verification of the prognostic value of the glutathione S‑transferase Mu genes in gastric cancer

Contact Info

Product

Resources

About