Glutathione S-transferase influences the fecundity of Schistosoma japonicum

Tang, Chaoliang; Zhou, Hong-hua; Zhu, Yawen; Huang, Jin; Wang, Guobo

doi:10.1016/j.actatropica.2018.12.027

Cited by 24 publications

(8 citation statements)

References 18 publications

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“…The egg reduction rate (18%) and abnormal egg ratio (28%) were significantly higher in the GST-deficient group than in the negative control group. These results support the notion that parasitic GST plays an important part in the fecundity of trematodes, specifically in egg formation [ 48 ].…”

Section: Functionality Of Trematoda Xenobiotic-metabolizing Enzymes: ...supporting

confidence: 89%

“…C. sinensis GST omega proteins may be crucial for the protection of the reproductive system during the maturation of C. sinensis worms and in response to oxidative conditions, thereby contributing to the maintenance of parasite fecundity [ 22 ]. A GST knockdown via RNA interference in S. japonicum worms resulted in a silencing rate higher than 80% [ 48 ]. The egg reduction rate (18%) and abnormal egg ratio (28%) were significantly higher in the GST-deficient group than in the negative control group.…”

Section: Functionality Of Trematoda Xenobiotic-metabolizing Enzymes: ...mentioning

confidence: 99%

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Xenobiotic-Metabolizing Enzymes in Trematodes

Мордвинов

Pakharukova

2022

Biomedicines

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Trematode infections occur worldwide causing considerable deterioration of human health and placing a substantial financial burden on the livestock industry. The hundreds of millions of people afflicted with trematode infections rely entirely on only two drugs (praziquantel and triclabendazole) for treatment. An understanding of anthelmintic biotransformation pathways in parasites should clarify factors that can modulate therapeutic potency of anthelmintics currently in use and may lead to the discovery of synergistic compounds for combination treatments. Despite the pronounced epidemiological significance of trematodes, there is still no adequate understanding of the functionality of their metabolic systems, including xenobiotic-metabolizing enzymes. The review is focused on the structure and functional significance of the xenobiotic-metabolizing system in trematodes. Knowledge in this field can solve practical problems related to the search for new targets for antiparasitic therapy based on a focused action on certain elements of the parasite’s metabolic system. Knowledge of the functionality of this system is required to understand the adaptation of the biochemical processes of parasites residing in the host and mechanisms of drug resistance development, as well as to select a promising molecular target for the discovery and development of new anthelmintic drugs.

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Section: Functionality Of Trematoda Xenobiotic-metabolizing Enzymes: ...supporting

confidence: 89%

Section: Functionality Of Trematoda Xenobiotic-metabolizing Enzymes: ...mentioning

confidence: 99%

Xenobiotic-Metabolizing Enzymes in Trematodes

Мордвинов

Pakharukova

2022

Biomedicines

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“…Furthermore, FEC can be blended with an organic linear carbonate. Hereby, the replacement of hydrogen by fluorine leads to an improvement in cycling stability because of suppressed electrolyte decomposition as well as a decrease in the cell resistance and the formation of an effective SEI . The FEC‐containing electrolyte forms a dense and thick SEI layer, which consists mainly of LiF (Figure ) …”

Section: Fluorinated Solventsmentioning

confidence: 99%

Fluorine and Lithium: Ideal Partners for High‐Performance Rechargeable Battery Electrolytes

et al. 2019

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Further enhancement in the energy densities of rechargeable lithium batteries calls for novel cell chemistry with advanced electrode materials that are compatible with suitable electrolytes without compromising the overall performance and safety, especially when considering high‐voltage applications. Significant advancements in cell chemistry based on traditional organic carbonate‐based electrolytes may be successfully achieved by introducing fluorine into the salt, solvent/cosolvent, or functional additive structure. The combination of the benefits from different constituents enables optimization of the electrolyte and battery chemistry toward specific, targeted applications. This Review aims to highlight key research activities and technical developments of fluorine‐based materials for aprotic non‐aqueous solvent‐based electrolytes and their components along with the related ongoing scientific challenges and limitations. Ionic liquid‐based electrolytes containing fluorine will not be considered in this Review.

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“…The compound is well‐known for its participation in SEI formation on graphite,,,,, Li metal, or silicon,, based anodes. Meanwhile, the compound is considered as an important constitute in HV applications acting as cathode passivation agent, thus forming a stable cathode electrolyte interphase (CEI) ,,. Compounds B (4‐trifluoromethyl‐1,3‐dioxolan‐2‐one, TFEC) and C , were also shown to participate in the SEI formation process, when used either as a single or as a co‐solvent (also with LiNi 0.5 Mn 1.5 O 4 cathodes) .…”

Section: Introductionmentioning

confidence: 99%

Simple Green Synthesis and Electrochemical Performance of a New Fluorinated Carbonate as Additive for Lithium‐Ion Batteries

et al. 2018

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A fluorinated carbonate (4‐(2,2,3,3,4,4,5,5,5‐nonafluoro‐pentyl)‐1,3‐dioxolan‐2‐one, 1) was synthesized from the corresponding oxirane through a one‐step carbonation reaction. The compound was obtained in quantitative yield with battery‐grade purity on a 50 g scale. Carbonate 1 was fully characterized by NMR, IR, MS, and crystal structure analysis. The compound melts at 98 °C and decomposes at 168 °C. When used as additive in lithium‐ion half‐ and full‐cell tests, 1 exhibited no reactivity toward the graphite anode, no participation in the solid‐electrolyte interphase (SEI) formation and led to a higher oxidation stability of the electrolyte against a carbon black electrode, compared to 4‐fluoro‐ethylenecarbonate and 4‐trifluoromethyl‐1,3‐dioxolan‐2‐one. The facile, clean, and scalable one‐step synthesis of 1 combined with its electrochemical behavior characterizes it as a promising additive for high voltage applications in lithium‐ion batteries.

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Glutathione S-transferase influences the fecundity of Schistosoma japonicum

Cited by 24 publications

References 18 publications

Xenobiotic-Metabolizing Enzymes in Trematodes

Xenobiotic-Metabolizing Enzymes in Trematodes

Fluorine and Lithium: Ideal Partners for High‐Performance Rechargeable Battery Electrolytes

Simple Green Synthesis and Electrochemical Performance of a New Fluorinated Carbonate as Additive for Lithium‐Ion Batteries

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